Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil

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Arquivos
art_LEAL_Recombinant_Strains_of_Human_Parechovirus_in_Rural_Areas_2019.PDF (1.34 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
LEAL, Elcio
LUCHS, Adriana
KOMNINAKIS, Shirley Vasconcelos
LOBATO, Marcia Cristina Alves Brito Sayao
BRUSTULIN, Rafael
CHAGAS, Rogerio Togisaki das
ABRAO, Maria de Fatima Neves dos Santos
SOARES, Cassia Vitoria de Deus Alves
Citação
VIRUSES-BASEL, v.11, n.6, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
We characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 17. A more detailed analysis revealed a high frequency of recombinant strains (58%): A total of 14 of our PeV-As were chimeric, with four distinct recombination patterns identified. Five strains were composed of genotypes 1 and 5 (Rec1/5); five strains shared a complex mosaic pattern formed by genotypes 4, 5, and 17 (Rec4/17/5); two strains were composed of genotypes 1 and 17 (Rec1/17); and two strains were composed of genotype 1 and an undetermined strain (Rec1/und). Coalescent analysis based on the Vp1 gene, which is free of recombination, indicated that the recombinant strains most likely arose in this region approximately 30 years ago. They are present in high frequencies and are circulating in different small and isolated cities in the state of Tocantins. Further studies will be needed to establish whether the detected recombinant strains have been replacing parental strains or if they are co-circulating in distinct frequencies in Tocantins.
Palavras-chave
parechovirus, picornavirus, virome, recombination, coalescent, Brazil
URI
https://observatorio.fm.usp.br/handle/OPI/33103
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - LIM/49
Artigos e Materiais de Revistas Científicas - LIM/58