Transcranial direct current stimulation for the treatment of generalized anxiety disorder: A randomized clinical trial

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art_LIMA_Transcranial_direct_current_stimulation_for_the_treatment_of_2019.PDF (755.9 KB)
Citações na Scopus
31
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER
Autores
LIMA, Ana Lucia de
BRAGA, Francisco Moises Azevedo
COSTA, Rodrigo Maciel Medeiros da
GOMES, Elihab Pereira
PEGADO, Rodrigo
Autor de Grupo de pesquisa
Citação
JOURNAL OF AFFECTIVE DISORDERS, v.259, p.31-37, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Generalized anxiety disorder (GAD) is a common condition with current treatments being only moderately effective. Non-invasive brain stimulation techniques might provide a novel approach for treating GAD. Transcranial direct current stimulation (tDCS) has shown promising efficacy and tolerability for major depression but has not been investigated for GAD yet. Thus, we investigated the effects of tDCS on patients with GAD. Methods: We conducted a pilot, double-blind, randomized, sham-controlled trial on 30 GAD patients. Five sessions of tDCS (2 mA, 20 min, anode over the left dorsolateral prefrontal cortex and cathode over the right supraorbital cortex) were performed. Anxiety was the primary outcome and it was measured by the Hamilton Anxiety Rating Scale and the Beck Anxiety Inventory. Secondary outcomes were accessed by the Lipp Inventory of Stress Symptoms for Adults, Positive and Negative Affect Schedule, and the Beck Depression Inventory (BDI). Data were examined at baseline, after the 5th day of intervention, and at 1-week follow-up. Results: Thirty patients finished the study. There were no significant improvements in anxiety, mood symptoms of stress, affectivity or depression. Anodal stimulation of the left DLPFC showed significant improvements in physical symptoms of stress in GAD patients. Limitations: Additional tDCS sessions could have resulted in larger tDCS effects. Conclusion: Five sessions of anodal tDCS over the DLPFC did not improve the main outcomes for GAD patients, although physical symptoms of stress were improved. The role of tDCS in GAD should be explored in larger patient samples using different parameters.
Palavras-chave
Noninvasive brain stimulation, Dorsolateral prefrontal cortex, Depression, Affectivity, Stress
URI
https://observatorio.fm.usp.br/handle/OPI/33923
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/27