Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients

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art_JOAQUIM_Decreased_plasmatic_spermidine_and_increased_spermine_in_mild_2019.PDF (279.27 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2019
DOI
SciELO
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
UNIV SAO PAULO, INST PSIQUIATRIA
Autores
Citação
ARCHIVES OF CLINICAL PSYCHIATRY, v.46, n.5, p.120-124, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective: The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (MCI) and AD patients in comparison with healthy controls (HC). Methods: Plasmatic polyamines were quantified using the AbsoluteIDQ (R) p1130 and liquid chromatography coupled to tandem mass spectrometry (LC/MS-MS). Results: The study group comprised 34 AD patients, 20 MCI and 25 HC. All individuals were followed for 4 years. During this period 8 amnestic MCI patients (40% of the MCI sample at baseline) converted to AD. Spermidine level was lower in both patient groups (AD; MCI) compared to HC (p = 0.007). Plasma levels of spermine were higher in the MCI group (p < 0.001), but decreased in the sub-sample of MCI patients who converted to AD (p = 0.043). No statistically significant differences were found in ornithine and putrescine levels (p = 0.056 and p = 0.126, respectively). Discussion: Our results suggest dynamic changes in the expression of polyamines in the MCI-AD continuum.
Palavras-chave
Biomarkers, Alzheimer's disease, mild cognitive impairment, polyamines, plasma
URI
https://observatorio.fm.usp.br/handle/OPI/34527
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/27