Cancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinoma

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art_MATOS_Cancerassociated_fibroblast_regulation_by_microRNAs_promotes_invasion_of_2020.PDF (4.08 MB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER
Autores
THEODORO, Therese Rachell
ISHIKAWA, Marina de Menezes
PINHAL, Maria Aparecida da Silva
Citação
ORAL ONCOLOGY, v.110, article ID 104909, 9p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of oral squamous cell carcinoma and to evaluate its relationship with the prognosis of these patients. This was a retrospective study on material from the paraffin blocks of patients operated on for oral squamous cell carcinoma, in addition to a group of healthy oral mucosa samples of paired patients. miR-1-3p, miR-133-3p, and miR-21-5p were differentially expressed between the superficial and deep tumor groups. miR-21-5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. By immunohistochemistry, the group of deep tumors showed greater immunoreactivity to matrix metalloproteinases 2 and 9 and laminin a in tumor-associated fibroblasts, with consequent degradation of the basal membrane, measured by greater loss of continuity of type IV collagen. This process was also associated with lower and higher expression of miR-1-3p and miR-21-5p, respectively. There was also a trend toward better overall and disease-free survival rates in patients with higher miR-133a-3p. The present study showed the interaction between microRNAs and extracellular matrix remodeling in oral squamous cell carcinoma.
Palavras-chave
Carcinoma, squamous cell, Mouth, microRNAs, Neoplasm invasiveness, Carcinogenesis
URI
https://observatorio.fm.usp.br/handle/OPI/39362
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/08
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