AIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphisms

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art_PRATES_AIDS_incidence_and_survival_in_a_hospitalbased_cohort_2021.PDF (2.64 MB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
VEIGA, Ana Paula R.
Citação
JOURNAL OF MEDICAL VIROLOGY, v.93, n.6, p.3601-3606, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Few studies have reported the prognosis of human immunodeficiency virus (HIV)-positive patients followed for a long time in Brazil, particularly those including pre and post-HAART eras. The polymorphisms of interferon (IFN)-lambda 4 have been postulated as possibly associated with the pathogenesis of HIV infection. The aim of this study was to describe the incidence and mortality from a cohort of HIV-positive patients as well as whether IFN-lambda 4 gene polymorphisms (SNP rs8099917 and SNP rs12979860) were associated with HIV/acquired immune deficiency syndrome (AIDS) progression. We followed 402 patients for up to 30 years; 347 of them began follow-up asymptomatic, without any AIDS-defining opportunistic disease and/or a lymphocytes T CD4+ count of 350 cells/mm(3)or lower. We determined the probability of the asymptomatic subjects to remain AIDS-free, and the risk of death for those entering the study already with an AIDS diagnosis, as well as for subjects developing AIDS during follow-up. We compared the prognosis of patients with two different polymorphisms for the genes encoding for IFN-lambda 4, variants rs8099917 and rs12979860. The follow-up time of the 347 asymptomatic-at-entry subjects was 3687 person-years. IFN-lambda 4 rs8099917 polymorphisms were not associated with AIDS progression, but IFN-lambda 4 rs12979860 wild type genotype (CC) was associated with higher mortality compared to CT and TT, with an increased probability of death from AIDS (P = .01). In conclusion, genetic variations in IFN-lambda 4 on rs12979860 polymorphisms in HIV-infected patients may drive mortality risk.
Palavras-chave
HIV-1, IFN-lambda 4, SNP, viral load
URI
https://observatorio.fm.usp.br/handle/OPI/40851
Referências
  1. Ank N, 2008, J IMMUNOL, V180, P2474, DOI 10.4049/jimmunol.180.4.2474
  2. Assone T, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003199
  3. Casseb J, 2018, AIDS RES HUM RETROV, V34, P165, DOI [10.1089/aid.2017.0106, 10.1089/AID.2017.0106]
  4. Alves CFD, 2016, GENET MOL BIOL, V39, P374, DOI 10.1590/1678-4685-GMB-2015-0106
  5. Ding JW, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191930
  6. Fonseca LAM, 1999, INT J EPIDEMIOL, V28, P1156, DOI 10.1093/ije/28.6.1156
  7. Ge DL, 2009, NATURE, V461, P399, DOI 10.1038/nature08309
  8. He C, 2019, MED MICROBIOL IMMUN, V208, P239, DOI 10.1007/s00430-019-00585-x
  9. Hermant P, 2014, J INNATE IMMUN, V6, P563, DOI 10.1159/000360084
  10. Lazear HM, 2015, IMMUNITY, V43, P15, DOI 10.1016/j.immuni.2015.07.001
  11. Machmach K, 2013, J INFECT DIS, V207, P651, DOI 10.1093/infdis/jis717
  12. McLaren PJ, 2017, J INFECT DIS, V216, P1063, DOI 10.1093/infdis/jix470
  13. Parczewski M, 2012, AIDS RES HUM RETROV, V28, P1640, DOI [10.1089/aid.2011.0354, 10.1089/AID.2011.0354]
  14. Sadler AJ, 2008, NAT REV IMMUNOL, V8, P559, DOI 10.1038/nri2314
  15. Sajadi MM, 2011, CTS-CLIN TRANSL SCI, V4, P282, DOI 10.1111/j.1752-8062.2011.00307.x
  16. Thomas DL, 2009, NATURE, V461, P798, DOI 10.1038/nature08463
  17. Valenzuela-Ponce H, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23849-7

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/38
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