Interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms in persistent IgE-mediated cow's milk allergy
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Citações na Scopus
15
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
GUSHKEN, Andrea Keiko F.
WATANABE, Leticia Aki
FRUCCHI, Vanessa C. Z.
Citação
CLINICS, v.68, n.7, p.1004-1009, 2013
Resumo
OBJECTIVES: The aim of this cross-sectional study was to evaluate whether interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms were associated with persistent IgE-mediated cow's milk allergy in 50 Brazilian children. The diagnostic criteria were anaphylaxis triggered by cow's milk or a positive double-blind, placebo-controlled food challenge. Tolerance was defined as the absence of a clinical response to a double-blind, placebo-controlled food challenge or cow's milk exposure. METHOD: The genomic DNA of the 50 patients and 224 healthy controls (HCs) was used to investigate five IL10 gene polymorphisms (-3575A/T, -2849A/G, -2763A/C, -1082G/A, -592C/A) and one TGF beta 1 polymorphism (-509C/T). RESULTS: Among the five IL10 polymorphisms analyzed, homozygosis for the G allele at the -1082 position was significantly higher in the patients compared with the healthy controls (p = 0.027) and in the persistent cow's milk allergy group compared with the healthy controls (p = 0.001). CONCLUSIONS: Homozygosis for the G allele at the IL10 -1082G/A polymorphism is associated with the persistent form of cow's milk allergy.
Palavras-chave
Food Hypersensitivity, Cow's Milk Allergy, Clinical Outcome, Gene Polymorphism, Interleukin 10, Transforming Growth Factor beta 1
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