Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate
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Citações na Scopus
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Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
GONCALVES, Ana Lucia R.
COSTA, Idessania N.
CHIEFFI, Pedro Paulo
COSTA-CRUZ, Julia Maria
Citação
PARASITE IMMUNOLOGY, v.44, n.7, article ID e12920, 5p, 2022
Resumo
Strongyloidiasis is a chronic and asymptomatic infection in immunocompetent patients. Immunocompromised patients, such as organ transplant candidates, can develop severe forms of this disease, and the best way to prevent progression to these forms is early diagnosis. Serological techniques using specific IgG and immune complexes (IC) detection can help in the diagnosis of these patients. This study aimed to detect specific anti-Strongyloides IC and IgG antibodies in kidney transplant (KT) and liver transplant (LT) candidates. A total of 100 blood samples was collected from transplant candidates (50 blood samples each from KT and LT candidates). Serum was obtained and analysed using enzyme-linked immunosorbent assay for IC and IgG detections. The IC levels showed frequencies of 18% and 2% in the KT and LT groups, respectively, whereas anti-Strongyloides IgG was detected in 34% and 12% of KT and LT candidates, respectively. The correlation between IC and IgG detection is poor in KT candidates, while in LT candidates, there is a significant positive correlation. The detection of IC can be an additional tool for the diagnosis of strongyloidiasis, especially when associated with the detection of specific IgG anti-Strongyloides antibodies.
Palavras-chave
human strongyloidiasis, immune complexes, immunodiagnostic, transplant candidates
Referências
- Abanyie FA, 2018, TRANSPL INFECT DIS, V20, DOI 10.1111/tid.12865
- Batista MV, 2011, TROP MED INT HEALTH, V16, P1134, DOI 10.1111/j.1365-3156.2011.02816.x
- Boggild A K, 2016, Can Commun Dis Rep, V42, P12
- Bosqui LR, 2018, PARASITOLOGY, V145, P1090, DOI 10.1017/S0031182017002232
- Bosqui LR, 2021, PARASITE IMMUNOL, V43, DOI 10.1111/pim.12793
- Buonfrate D, 2020, PATHOGENS, V9, DOI 10.3390/pathogens9060468
- Corral MA, 2019, ACTA TROP, V190, P357, DOI 10.1016/j.actatropica.2018.12.020
- Corral MA, 2015, REV INST MED TROP SP, V57, P77, DOI 10.1590/S0036-46652015000100011
- de Carvalho CA, 2013, ACTA TROP, V125, P128, DOI 10.1016/j.actatropica.2012.10.010
- de Paula FM, 2016, REV INST MED TROP SP, V58, DOI 10.1590/S1678-9946201658063
- de Paula FM, 2013, REV INST MED TROP SP, V55, P291, DOI 10.1590/S0036-46652013000400013
- Eslahi AV, 2021, PATHOG GLOB HEALTH, V115, P7, DOI 10.1080/20477724.2020.1851922
- Frank Michael M., 2009, P79, DOI 10.1007/978-4-431-88315-9_6
- Garcia LS., 2001, DIAGNOSTIC MED PARAS, V4th
- Goncalves ALR, 2016, J HELMINTHOL, V90, P342, DOI 10.1017/S0022149X15000346
- Goncalves ALR, 2012, PARASITOLOGY, V139, P956, DOI 10.1017/S0031182012000054
- Goncalves AAS, 2018, PARASITOL INT, V67, P644, DOI 10.1016/j.parint.2018.06.007
- Goncalves ALR, 2012, EXP PARASITOL, V130, P205, DOI 10.1016/j.exppara.2012.01.007
- Levenhagen MA, 2014, ACTA TROP, V135, P33, DOI 10.1016/j.actatropica.2014.03.015
- LOWRY OH, 1951, J BIOL CHEM, V193, P265
- Machado ER, 2003, MEM I OSWALDO CRUZ, V98, P849, DOI 10.1590/S0074-02762003000600024
- Mendonca SCL, 2006, ACTA TROP, V99, P102, DOI 10.1016/j.actatropica.2006.06.006
- Miglioli-Galvao L, 2020, PLOS NEGLECT TROP D, V14, DOI 10.1371/journal.pntd.0007998
- Miguel CB, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/4086929
- Olsen A, 2009, T ROY SOC TROP MED H, V103, P967, DOI 10.1016/j.trstmh.2009.02.013
- Roxby AC, 2009, CLIN INFECT DIS, V49, P1411, DOI 10.1086/630201
- Schar F, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002288
- Sekhawat V, 2020, HISTOPATHOLOGY, V77, P156, DOI 10.1111/his.14111
- Teixeira MCA, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/4872473
- Toledo B, 2019, CLINICS, V74, DOI 10.6061/clinics/2019/e698