The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder

Imagem de Miniatura
Arquivos
art_SOEIRO-DE-SOUZA_The_CACNA1C_risk_allele_selectively_impacts_on_executive_2013.PDF (124.47 KB)
Citações na Scopus
28
Tipo de produção
article
Data de publicação
2013
Editora
WILEY-BLACKWELL
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
DIAS, V. V.
VIETA, E.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
ACTA PSYCHIATRICA SCANDINAVICA, v.128, n.5, p.362-369, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
ObjectiveCalcium channels are important for converting electrical activity into biochemical events. A single nucleotide polymorphism (SNP) (rs1006737) in the CACNA1C gene has been strongly associated with increased risk for Bipolar disorder (BD) in genome-wide association studies. Recently, this same SNP has been reported to influence executive function in schizophrenia and controls, but it remains unclear whether this SNP affects behaviour, especially cognition in subjects with BD. MethodA total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)]. ResultsIn patients with BD, the CACNA1C genotype Met/Met was associated with worse performance on all four executive function tests compared to Val/Val. No influence of CACNA1C was observed in the cognitive performance of healthy controls. ConclusionOur data indicate for the first time that the CACNA1C risk allele is likely associated with executive dysfunction as a trait in BD, as this association was found regardless the presence of mood symptoms. Larger studies should evaluate the potential influence of CACNA1C on other cognitive domains in BD.
Palavras-chave
calcium channel, executive function, CACNA1C, mania, depression, bipolar disorder, cognition
URI
https://observatorio.fm.usp.br/handle/OPI/5280
Referências
  1. Akimoto T, 2007, PROG NEURO-PSYCHOPH, V31, P136, DOI 10.1016/j.pnpbp.2006.08.008
  2. Arts B, 2013, PSYCHIAT GENET, V23, P41, DOI 10.1097/YPG.0b013e328358641c
  3. Arts B, 2011, ACTA PSYCHIAT SCAND, V123, P190, DOI 10.1111/j.1600-0447.2010.01601.x
  4. Balanza-Martinez V, 2008, NEUROSCI BIOBEHAV R, V32, P1426, DOI 10.1016/j.neubiorev.2008.05.019
  5. Bigos KL, 2010, ARCH GEN PSYCHIAT, V67, P939, DOI 10.1001/archgenpsychiatry.2010.96
  6. Bora E, 2009, J AFFECT DISORDERS, V113, P1, DOI 10.1016/j.jad.2008.06.009
  7. Campos RN, 2010, TRIALS, V11, DOI 10.1186/1745-6215-11-72
  8. Do Prado CM, 2012, BIPOLAR DISORD, V14, P554
  9. DSM-IV PATFO, 2000, DIAGN STAT MAN MENT
  10. Erk S, 2010, ARCH GEN PSYCHIAT, V67, P803, DOI 10.1001/archgenpsychiatry.2010.94
  11. Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
  12. First MB, 1996, STRUCTURED CLIN INTE
  13. Franke B, 2010, BIOL PSYCHIAT, V68, P586, DOI 10.1016/j.biopsych.2010.05.037
  14. Gargus JJ, 2009, ANN NY ACAD SCI, V1151, P133, DOI 10.1111/j.1749-6632.2008.03572.x
  15. Glahn DC, 2010, ARCH GEN PSYCHIAT, V67, P168, DOI 10.1001/archgenpsychiatry.2009.184
  16. HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
  17. Jogia J, 2011, MOL PSYCHIATR, V16, P1070, DOI 10.1038/mp.2011.49
  18. Kato T, 2008, CELL CALCIUM, V44, P92, DOI 10.1016/j.ceca.2007.11.005
  19. Kempton MJ, 2009, AM J PSYCHIAT, V166, P1413, DOI 10.1176/appi.ajp.2009.09050680
  20. Krug A, 2010, NEUROIMAGE, V49, P1831, DOI 10.1016/j.neuroimage.2009.09.028
  21. LAITINEN J, 1994, BIOTECHNIQUES, V17, P316
  22. Lezak M., 2004, NEUROPSYCHOLOGICAL A
  23. Liu Y, 2011, MOL PSYCHIATR, V16, P2, DOI 10.1038/mp.2009.107
  24. Machado-Vieira R, 2011, BIOL PSYCHIAT, V69, P344, DOI 10.1016/j.biopsych.2010.10.019
  25. Perrier E, 2011, EUR PSYCHIAT, V26, P135, DOI 10.1016/j.eurpsy.2010.10.004
  26. Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
  27. Quraishi S, 2002, J AFFECT DISORDERS, V72, P209, DOI 10.1016/S0165-0327(02)00091-5
  28. Roussos P, 2011, BIPOLAR DISORD, V13, P250, DOI 10.1111/j.1399-5618.2011.00924.x
  29. Savitz J, 2005, BIPOLAR DISORD, V7, P216, DOI 10.1111/j.1399-5618.2005.00203.x
  30. Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22
  31. Shifman S, 2004, AM J MED GENET B, V128B, P61, DOI 10.1002/ajmg.b.30032
  32. Shinnick-Gallagher P, 2003, ANN NY ACAD SCI, V985, P135
  33. Sklar P, 2002, MOL PSYCHIATR, V7, P579, DOI 10.1038/sj.mp.4001058
  34. Sklar P, 2011, NAT GENET, V43, P977, DOI 10.1038/ng.943
  35. Sklar P, 2008, MOL PSYCHIATR, V13, P558, DOI 10.1038/sj.mp.4002151
  36. Soeiro De Souza MG, 2012, J AFFECT DISORDERS, V141, P94
  37. Sole B, 2011, PSYCHOL MED, V41, P1791, DOI 10.1017/S0033291711000018
  38. Sourial-Bassillious N, 2009, NEUROSCIENCE, V161, P1126, DOI 10.1016/j.neuroscience.2009.04.013
  39. Strauss E., 2006, COMPENDIUM NEUROPSYC
  40. Thimm M, 2011, PSYCHOL MED, V41, P1551, DOI 10.1017/S0033291710002217
  41. Thompson JM, 2005, BRIT J PSYCHIAT, V186, P32, DOI 10.1192/bjp.186.1.32
  42. Wang F, 2011, BIPOLAR DISORD, V13, P696, DOI 10.1111/j.1399-5618.2011.00963.x
  43. Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
  44. Wechsler D., 1999, WECHSLER ABBREVIATED
  45. Wechsler D., 1981, WECHSLER ADULT INTEL
  46. Wessa M, 2010, MOL PSYCHIATR, V15, P1126, DOI 10.1038/mp.2009.103
  47. Hori H, 2012, SCI REP-UK, V2, DOI 10.1038/srep00634
  48. YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
  49. Zhang QM, 2012, NEUROPSYCHOPHARMACOL, V37, P677, DOI 10.1038/npp.2011.242

Coleções
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/27