Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil

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art_FERRUFINO_Factors_Associated_with_Spontaneous_Clearance_of_Recently_Acquired_.PDF (282.96 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
Citação
VIRUSES-BASEL, v.15, n.2, article ID 314, 10p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed the medical records from all PLWH at the human immunodeficiency virus (HIV) outpatient reference clinic affiliated with the University of Sao Paulo, Brazil, and identified, by immunoassays and RNA-PCR individuals who acquired HCV infection between January 2015 and December 2017. The factors associated with subsequent spontaneous clearance of the infection in this group were identified and analyzed. Results: Among 3143 PLWH individuals, 362 (11.5%) were coinfected with HCV. Forty-eight (13.2%) of these subjects first became HCV-positive between January 2015 and December 2017. Spontaneous HCV clearance was documented in 23 individuals (47.9%). The majority of this latter group were male (83.3%), and the median age was 31 years (23-39). The main risk group for HCV acquisition was men who had sex with men (MSM) (89.5%). In a multivariate analysis, only an elevated CD4+ T lymphocyte count at the time of seroconversion was found to be associated with subsequent HCV clearance (p = 0.025). Conclusions: In HIV-infected individuals in Sao Paulo, Brazil, most cases of recent HCV transmission were by sexual exposure. In PLWH, particularly in MSM, the individual's CD4+ T lymphocyte count is a determinant of whether an acquired HCV infection will be prolonged or will spontaneously clear.
Palavras-chave
HIV, coinfection, recently acquired hepatitis C infection, spontaneous clearance, immunity, acute HCV
URI
https://observatorio.fm.usp.br/handle/OPI/53052
Referências
  1. Abdel-Hakeem MS, 2014, GASTROENTEROLOGY, V147, P870, DOI 10.1053/j.gastro.2014.07.005
  2. Aisyah DN, 2018, J VIRAL HEPATITIS, V25, P680, DOI 10.1111/jvh.12866
  3. American Association for the Study of Liver Diseases and Infectios Diseases Society of America, REC TEST MAN TREAT H
  4. ARCA, 3 LEV NAC US DROG PE
  5. Benova L, 2014, CLIN INFECT DIS, V59, P765, DOI 10.1093/cid/ciu447
  6. Blach S, 2022, LANCET GASTROENTEROL, V7, P396, DOI 10.1016/S2468-1253(21)00472-6
  7. Brasil Ministerio da Saude, 2013, IMPL ROT TEST DEAC N, V1st
  8. Brasil. Ministerio da Saude, 2021, B EP HEP VIR
  9. Danta M, 2008, J INFECT DIS, V197, P1558, DOI 10.1086/587843
  10. Grebely J, 2012, LANCET INFECT DIS, V12, P408, DOI 10.1016/S1473-3099(12)70010-5
  11. Kenny-Walsh E, 1999, NEW ENGL J MED, V340, P1228, DOI 10.1056/NEJM199904223401602
  12. Lemon SM, 2010, J BIOL CHEM, V285, P22739, DOI 10.1074/jbc.R109.099556
  13. Luetkemeyer A, 2006, JAIDS-J ACQ IMM DEF, V41, P31, DOI 10.1097/01.qai.0000191281.77954.27
  14. Marincovich B, 2003, SEX TRANSM INFECT, V79, P160, DOI 10.1136/sti.79.2.160
  15. Marx MA, 2003, CLIN INFECT DIS, V37, P514, DOI 10.1086/376639
  16. Matthews GV, 2008, J HEPATOL, V49, P305, DOI 10.1016/j.jhep.2008.06.005
  17. Matthews GV, 2007, AIDS, V21, P2112, DOI 10.1097/QAD.0b013e3282ef3873
  18. Vieira PCM, 2017, TRANSFUSION, V57, P1968, DOI 10.1111/trf.14146
  19. Nascimbeni M, 2003, J VIROL, V77, P4781, DOI 10.1128/JVI.77.8.4781-4793.2003
  20. Oliveira AB, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-4270-2
  21. Roudot-Thoraval F, 2021, CLIN RES HEPATOL GAS, V45, DOI 10.1016/j.clinre.2020.101596
  22. Roy K, 2002, EPIDEMIOL INFECT, V129, P577, DOI 10.1017/S0950268802007902
  23. Seaberg EC, 2015, CLIN INFECT DIS, V61, P1381, DOI 10.1093/cid/civ562
  24. Serpaggi J, 2006, AIDS, V20, P233, DOI 10.1097/01.aids.0000200541.40633.56
  25. Silva FQ, 2018, ARCH VIROL, V163, P617, DOI 10.1007/s00705-017-3656-y
  26. Soriano V, 2008, J INFECT DIS, V198, P1337, DOI 10.1086/592171
  27. Tengan FM, 2016, BMC INFECT DIS, V16, DOI 10.1186/s12879-016-1988-y
  28. Terrault NA, 2013, HEPATOLOGY, V57, P881, DOI 10.1002/hep.26164
  29. Thomas DL, 2009, NATURE, V461, P798, DOI 10.1038/nature08463
  30. Thomas DL, 2000, JAMA-J AM MED ASSOC, V284, P450, DOI 10.1001/jama.284.4.450
  31. Thursz M, 2014, NAT REV GASTRO HEPAT, V11, P28, DOI 10.1038/nrgastro.2013.179
  32. Tillmann HL, 2010, GASTROENTEROLOGY, V139, P1586, DOI 10.1053/j.gastro.2010.07.005
  33. Urbani S, 2006, HEPATOLOGY, V44, P126, DOI 10.1002/hep.21242
  34. van de Laar T, 2009, GASTROENTEROLOGY, V136, P1609, DOI 10.1053/j.gastro.2009.02.006
  35. van de Laar TJW, 2007, J INFECT DIS, V196, P230, DOI 10.1086/518796
  36. van den Berg CHBS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027555
  37. Vandelli C, 2004, AM J GASTROENTEROL, V99, P855, DOI 10.1111/j.1572-0241.2004.04150.x
  38. Wang CC, 2007, J INFECT DIS, V196, P1474, DOI 10.1086/522608
  39. Wiese M, 2005, J HEPATOL, V43, P590, DOI 10.1016/j.jhep.2005.04.007

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/05