Hypotonic solution decreases serum sodium in infants with moderate bronchiolitis

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art_SCHVARTSMAN_Hypotonic_solution_decreases_serum_sodium_in_infants_with_2014.PDF (111.88 KB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
RODRIGUES, Regina M.
Citação
ACTA PAEDIATRICA, v.103, n.3, p.E111-E115, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
AimTo investigate the influence of hypotonic parenteral hydration on serum and urinary sodium and osmolality in infants with moderate bronchiolitis. MethodsWe studied 36 infants (mean age 3.72.3months), with a diagnosis of moderate bronchiolitis admitted to a paediatric emergency unit in SAo Paulo, Brazil. Patients received a standard parenteral hypotonic solution, according to Holliday and Segar, during the first 24h, due to respiratory distress. The disease was monitored by a respiratory severity score (RDAI-Respiratory Distress Assessment Instrument), respiratory rate and oxygen saturation. Serum and urinary sodium and osmolality were monitored at admission, 24 and 48h after admission. ResultsAll respiratory parameters improved during hospitalisation. Serum sodium and osmolality dropped after 24h (136.8 +/- 2.8 and 135.8 +/- 2.6mEq/L, p=0.031; 283.4 +/- 4.1 and 281.6 +/- 3.9 mOsm/kg, p=0.004 respectively) as well as urinary osmolality (486.8 +/- 243.4 mOsm/kg and 355.7 +/- 205.0 mOsm/kg, p<0.001) when compared to admission. ConclusionThis study reinforces the occurrence of hyponatraemia in bronchiolitis even in patients with moderate disease and highlights the risk of serum sodium drop caused by hypotonic parenteral hydration.
Palavras-chave
Hyponatraemia, Hypotonic solution, Moderate bronchiolitis, Paediatric
URI
https://observatorio.fm.usp.br/handle/OPI/5495
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICr