Abnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis
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Citações na Scopus
47
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Citação
AUTOIMMUNITY REVIEWS, v.11, n.11, Special Issue, p.827-835, 2012
Resumo
Objective: The physiological and mechanical properties of the skin, the primary tissue affected by systemic sclerosis, depend on the assembly of collagen types I, Ill and V, which form heterotypic fibers. Collagen V (COLV) regulates heterotypic fiber diameter, and the maintenance of its properties is important for maintaining normal tissue architecture and function. Based on a COLV-induced experimental SSc model, in which overexpression of abnormal COLV was a prominent feature, we assumed that this abnormality could be present in SSc patients and could be correlated to disease duration, skin thickening and disease activity. Methods: Skin biopsies from 18 patients (6 early-stage and 12 late-stage) and 10 healthy controls were studied. Skin thickening assessment was performed with the Modified Rodnan Skin Score (MRSS), and activity was calculated using the Valentini Disease Activity Index. Morphology, morphometry of COLV deposition in dermis, as well as, quantitative RT-PCR and 3D-reconstruction of the dermal fibroblast culture were performed. Results: Structurally abnormal COLV was overexpressed in SSc skin, mainly in the early stages of the disease, when compared to normal controls and late-stage. A positive correlation between COLV expression and MRSS and disease activity was observed. Collagen V alpha-1 and alpha-2 mRNA expression levels were higher in SSc. Tridimensional reconstruction of SSc dermal heterotypic fibers confirmed the presence of atypical COLV. Conclusion: Increased synthesis of abnormal COLV and its correlation with disease stage, activity and MRSS suggest that this collagen can be a possible trigger involved in the pathogenesis of SSc.
Palavras-chave
Systemic sclerosis, Type V collagen, Skin, Modified Rodnan Skin Score, Valentini Disease Activity Index
Referências
- Behr J, 2008, RHEUMATOLOGY, V47, pV65, DOI 10.1093/rheumatology/ken313
- Bezerra MC, 2006, ARCH DERMATOL RES, V298, P51, DOI 10.1007/s00403-006-0645-5
- Bharat A, 2006, AM J TRANSPLANT, V6, P1799, DOI 10.1111/j.1600-6143.2006.01383.x
- BIRK DE, 1990, J CELL SCI, V95, P649
- Birk DE, 2001, MICRON, V32, P223, DOI 10.1016/S0968-4328(00)00043-3
- Brinckmann J, 2005, MATRIX BIOL, V24, P459, DOI 10.1016/j.matbio.2005.07.002
- Callado MRM, 2007, IMMUNOLOGY, V122, P38, DOI 10.1111/j.1365-2567.2007.02610.x
- Chanut-Delalande H, 2004, MOL CELL BIOL, V24, P6049, DOI 10.1128/MCB.24.13.6049-6057.2004
- CLEMENTS P, 1995, J RHEUMATOL, V22, P1281
- Coelho JC, 2000, GENET MOL BIOL, V23, P269
- Corriveau MP, 2009, J PATHOL, V217, P534, DOI 10.1002/path.2482
- Cotton SA, 1999, J PATHOL, V189, P273, DOI 10.1002/(SICI)1096-9896(199910)189:2<273::AID-PATH413>3.3.CO;2-W
- de Oliveira CC, 2009, CLINICS, V64, P577, DOI 10.1590/S1807-59322009000600014
- Derk CT, 2003, AUTOIMMUN REV, V2, P181, DOI 10.1016/S1568-9972(03)00005-3
- FLEISCHMAJER R, 1978, ARTHRITIS RHEUM, V21, P418, DOI 10.1002/art.1780210404
- Gao MQ, 2010, J CELL SCI, V123, P3507, DOI 10.1242/jcs.072900
- Gelse K, 2003, ADV DRUG DELIVER REV, V55, P1531, DOI 10.1016/j.addr.2003.08.002
- Haque MA, 2002, J IMMUNOL, V169, P1542
- Henkel W, 2007, J PROTEOME RES, V6, P4269, DOI 10.1021/pr070318r
- Jaramillo A, 1999, TRANSPLANTATION, V67, P1155, DOI 10.1097/00007890-199904270-00012
- Laplante P, 2010, CELL DEATH DIFFER, V17, P291, DOI 10.1038/cdd.2009.124
- Liu T, 2008, J HUAZHONG U SCI-MED, V28, P599, DOI 10.1007/s11596-008-0525-7
- Luparello C, 2005, J CELL PHYSIOL, V202, P411, DOI 10.1002/jcp.20131
- Malfait F, 2010, GENET MED, V12, P597, DOI 10.1097/GIM.0b013e3181eed412
- Marangoni RG, 2011, ARTHRITIS RHEUM S, V62, pS253
- Marangoni RG, 2010, CLIN EXP RHEUMATOL S, V5, P31
- Pannu J, 2006, ARTHRITIS RHEUM, V54, P3011, DOI 10.1002/art.22063
- Parra ER, 2010, EUR J CLIN INVEST, V40, P110, DOI 10.1111/j.1365-2362.2009.02224.x
- Parra ER, 2009, CLIN RESPIR J, V3, P135, DOI 10.1111/j.1752-699X.2008.00118.x
- QUINONES F, 1986, AM REV RESPIR DIS, V134, P1163
- RIENTE L, 1995, CLIN EXP IMMUNOL, V102, P354
- Roulet M, 2007, CELL TISSUE RES, V327, P323, DOI 10.1007/s00441-006-0294-1
- Sakkas LI, 2002, J IMMUNOL, V168, P3649
- Sakkas LI, 2004, ARTHRITIS RHEUM, V50, P1721, DOI 10.1002/art.20315
- Sargent JL, 2010, J INVEST DERMATOL, V130, P694, DOI 10.1038/jid.2009.318
- Schmittgen TD, 2001, METHODS, V25, P402
- Sorrel MJ, 2004, J CELL PATHOL, V200, P134
- Souza P, 2010, HUM PATHOL, V41, P239, DOI 10.1016/j.humpath.2009.07.018
- Spiess K, 2007, CONNECT TISSUE RES, V48, P99, DOI 10.1080/03008200601166194
- Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria, 1980, ARTHRITIS RHEUM, V23, P581
- Teodoro WR, 2004, PATHOL RES PRACT, V200, P681, DOI 10.1016/j.prp.2004.05.007
- Valentini G, 2003, CLIN EXP RHEUMATOL, V21, pS39
- Velosa APP, 2010, RESP RES, V11, DOI 10.1186/1465-9921-11-1
- Velosa APP, 2007, ARCH DERMATOL RES, V299, P177, DOI 10.1007/s00403-007-0735-z
- Wells AU, 2008, RHEUMATOLOGY, V47, pV59, DOI 10.1093/rheumatology/ken271
- WHITE B, 1995, ARTHRITIS RHEUM, V38, P351, DOI 10.1002/art.1780380309
- Wigley FM, 2003, RHEUMATOLOGY, P1463
- Yasufuku K, 2002, TRANSPLANTATION, V73, P500, DOI 10.1097/00007890-200202270-00002
- Yasufuku K, 2001, AM J RESP CELL MOL, V25, P26
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Artigos e Materiais de Revistas Científicas - FM/MDT
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Artigos e Materiais de Revistas Científicas - LIM/17
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Artigos e Materiais de Revistas Científicas - FM/MDR
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Artigos e Materiais de Revistas Científicas - LIM/17