MAYSA VIEIRA DE SOUSA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/18 - Laboratório de Carboidratos e Radioimunoensaios, Hospital das Clínicas, Faculdade de Medicina
LIM/18 - Laboratório de Carboidratos e Radioimunoensaios, Hospital das Clínicas, Faculdade de Medicina
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- Effect of sprint and strength training on glucoregulatory hormones: Effect of advanced age(2017) SELLAMI, Maha; ABDERRAHMAN, Abderraouf Ben; KEBSI, Wiem; SOUSA, Maysa Vieira De; ZOUHAL, HassaneThe aim of this study was to examine the effect of high-intensity sprint and strength training (HISST) on glucoregulatory hormones in young (20 years) and middle-aged (40 years) men. Thirty-six moderately trained men participated as volunteers in this study. After medical examination, eligible subjects were randomly assigned to one of four groups according to their age: a young training group (21.3 +/- 1.3 yrs, YT, n = 9), a young control group (21.4 +/- 1.7 yrs, YC, n = 9), a middle-aged training group (40.7 +/- 1.8 yrs, AT, n = 9), and a middle-aged control group (40.5 +/- 1.8 yrs, AC, n = 9). YT and AT participated in HISST for 13 weeks. Before and after HISST, all participants performed the Wingate Anaerobic Test (WAnT). Blood samples were collected at rest, after warm-up (50% VO2max), immediately post-WAnT, and 10 min post-WAnT. Before HISST, we observed significantly higher (P < 0.05) glucose concentrations in AT (5.86 +/- 0.32 mmol. L-1) compared to YT (4.24 +/- 0.79 mmol. L-1) at rest, and in response to WAnT (6.56 +/- 0.63 mmol. L-1 vs. 5.33 +/- 0.81 mmol. L-1). Cortisol levels were significantly higher (P< 0.05) in AT than in YT in response to WAnT (468 +/- 99.50 ng. mL(-1) vs. 382 +/- 64.34 ng. mL(-1)). Catecholamine levels measured at rest and in response to WAnT rose in a similar fashion. After HISST, this ""age effect'' disappeared at rest and in response to exercise in the trained groups (YT and AT). Changes in hormone concentrations with intense training are due to adaptive changes in various tissues, especially in the skeletal muscle and liver in trained subjects. HISST may, at least in part, counteract the negative ""age effect'' on glucose metabolism.
- Plyometric exercise combined with high-intensity interval training improves metabolic abnormalities in young obese females more so than interval training alone(2016) RACIL, Ghazi; ZOUHAL, Hassane; ELMONTASSAR, Wassim; ABDERRAHMANE, Abderraouf Ben; SOUSA, Maysa Vieira De; CHAMARI, Karim; AMRI, Mohamed; COQUART, Jeremy B.The aim of this study was to compare the effects of 12 weeks of high-intensity interval training (HIIT) with the effects of 12 weeks of plyometric exercise combined with HIIT (P+HIIT) on anthropometric, biochemical, and physical fitness data in young obese females. Sixty-eight participants (age, 16.6 +/- 1.3 y; body mass, 82.8 +/- 5.0 kg; body fat, 39.4% +/- 3.3%; body mass index z score, 2.9 +/- 0.4) were assigned to 1 of 3 groups: HIIT (2 blocks per session of 6-8 bouts of 30-s runs at 100% velocity at peak oxygen uptake, with 30-s active recovery between bouts at 50% velocity at peak oxygen uptake (n = 23)); P+HIIT (2 blocks per session of 3 different 15-s plyometric exercises with 15-s passive recoveries, totaling 2 min for each plyometric exercise + the same HIIT program (n = 26)); or control (no exercise (n = 19)). Anthropometric (body mass, body mass index z score, body fat, lean body mass, and waist circumference), biochemical (plasma glucose, insulin, leptin and adiponectin concentrations, leptin/adiponectin ratio, and homeostasis model assessment of insulin resistance (HOMA-IR)), physical fitness (peak oxygen uptake, velocity at peak oxygen uptake, squat jump, and countermovement jump performances), and energy intake data were collected. Both training programs improved the anthropometric, biochemical, and physical fitness variables. However, the P+HIIT program induced greater improvements than did the HIIT program in lean body mass (+3.0% +/- 1.7%), plasma glucose and leptin concentrations (-11.0% +/- 4.7% and -23.8% +/- 5.8%, respectively), plasma leptin/adiponectin ratio (-40.9% +/- 10.9%), HOMA-IR (-37.3% +/- 6.2%), and squat jump performance (22.2% +/- 7.5%). Taken together, these findings suggest that adding plyometric exercises to a HIIT program may be more beneficial than HIIT alone in obese female adolescents.
- Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men(2019) KOLANDOUZI, Sarkawt; BAGHADAM, Mohammad; KANI-GOLZAR, Farhad Ahmadi; SAEIDI, Ayoub; JABBOUR, Georges; AYADI, Amani; SOUSA, Maysa De; ZOUITA, Amira; ABDERRAHMANE, Abderraouf Ben; ZOUHAL, HassaneBackground: Circuit resistance training (CRT) is a time-efficient exercise modality for improving skeletal muscle and cardiovascular fitness. But the beneficial role of CRT in obese individuals is still not well understood. This study explores the reducing effects of progressive CRT on inflammatory biomarkers and cardiometabolic risk factors in obese young men. Methods: Thirty obese men (Body mass index (BMI): 30.67 +/- 3.06; age: 23 +/- 3.2 years) were divided into CRT and control groups. The CRT was performed for eight-weeks (3 times/week, 65-85% of 1 repetition maximum). Fasting blood samples were taken pre and post intervention for analyzing apelin, chemerin, serum amyloid A (SAA), C reactive protein concentrations (CRP), lipid profile, and insulin resistance index. The data were assessed by two-way repeated measures ANOVA. Results: Body mass, BMI and waist to hip ratio (WHR) were significantly decreased after training intervention (P<.05). Compared to the control group, the plasma concentrations of Chemrin (P =.038), SAA (P =.004), insulin (P<.001), insulin resistance index (P<.001), total cholesterol (P =.033), triglyceride (P<.001), and low-density lipoprotein (P = .039), were significantly mitigated in the CRT group, but high-density lipoprotein plasma levels increased in the CRT group compared to that of the control group (P =.035). There was no significant difference between two groups in apelin and CRP (P>.05). Moreover, insulin resistance was positively correlated with apelin (r = 0.56) and chemerin (r = 0.51). Also, chemerin had a positive correlation with SAA (r = 0.49), and WHR (r = 0.54). Conclusion: CRT caused an improvement in inflammation and cardiometabolic risk factors in young obese men, and this improvement was accompanied by decreased insulin resistance.
- Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet(2019) SOUSA, Maysa V. de; FUKUI, Rosa; DAGOGO-JACK, Samuel; KRUSTRUP, Peter; ZOUHAL, Hassane; SILVA, Maria Elizabeth R. daBackground: We investigated the biomarkers of insulin action as well as changes in free fatty acids and lactate concentration after an acute soccer session pre and post training with caloric-restricted diet versus diet alone in type 2 diabetes (T2D) patients. Methods: Fifty-one middle-aged (61.1 +/- 6.4 years) T2D patients were randomly allocated to the soccer + diet group (SDG) or the diet group (DG). The control group comprised T2D patients observing a caloric-restricted diet who did not receive soccer training. Over 12 weeks, SDG performed 3 x 40 min per week of soccer training. Results: The first soccer session for SDG induced acute increases in blood lactate (1.4 +/- 0.1-6.0 +/- 0.7 mmol/l, P < 0.05) and glucagon levels (112.1 +/- 6.2-142.9 +/- 8.0 pg/ml, P < 0.05), whereas glucose and insulin levels remained unchanged. Moreover, this session showed suppressed insulin levels as well as higher free fatty acids, lactate levels and glucagon/insulin ratio compared to DG (p < 0.05). After 12 weeks, a baseline decrease was observed in glucagon, leptin and lactate levels in SDG and DG (p < 0.05), whereas HOMA-IR, Adipo-IR and glucose levels were lower only in SDG (p < 0.05). At the last soccer training session, the blood lactate response was significantly lower than for the first session (4.0 +/- 0.4 vs 6.0 +/- 0.7 mmol/l). At 48 h pre intervention, a decrease was observed in leptin levels (p < 0.05), which remained lower post intervention. The positive correlation between leptin and insulin, and the lower levels after training, could be attributed to the improved insulin sensitivity along with the weight loss observed in both groups (similar to 3.4 kg for DG and 3.7 kg for SDG). Conclusion: Acute soccer sessions markedly improved insulin action markers in T2D patients, while the cumulative effects enhanced insulin sensitivity and decreased risk factors associated with cardiovascular disease after 12 weeks of intervention better than caloric-restricted diet.