Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development

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Arquivos
art_PAULA_Characteristics_of_aquaporin_1_3_and_5_expression_2021.PDF (3.68 MB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
PAULA, Fernanda de
TUCKER, Abigail S.
TESHIMA, Tathyane Harumi N.
SOUZA, Milena Monteiro de
COUTINHO-CAMILLO, Claudia Malheiros
Citação
JOURNAL OF ANATOMY, v.238, n.3, p.794-806, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aquaporins (AQPs) are essential to coordinate the transit of water and ions through the cell membrane. In salivary glands (SGs), AQPs have been associated with saliva formation, facilitating water absorption through the epithelium during the formation of hypotonic saliva, which is then secreted into the oral cavity. Different members of the AQP family have been suggested to play distinct roles during embryonic development, highlighted by their specific expression patterns. Here, we have investigated the expression patterns of AQP-1, AQP-3 and AQP-5 by immunofluorescence at key stages of salivary gland development, utilising cultured mouse embryonic submandibular (SMG) and sublingual (SLG) glands. The expression of AQPs was compared to a mitotic marker, phospho-histone 3 (PH3), a myoepithelial marker, smooth muscle actin (SMA), and a vascular marker, CD31. Qualitative analysis revealed that AQP-1 and AQP-3 were primarily expressed during the earlier phases of SG morphogenesis and were associated with cells undergoing mitotic processes (PH3-positive). AQP-5, in contrast, was not associated to mitotic figures, but was predominantly expressed during late stages of SG morphogenesis. Our results highlight that AQPs are expressed from early stages of SG morphogenesis and exhibit complimentary expression patterns that may contribute to the morphogenesis of salivary glands.
Palavras-chave
aquaporin, development, expression, mitosis, salivary gland
URI
https://observatorio.fm.usp.br/handle/OPI/39158
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/06