PAULO EURIPEDES MARCHIORI
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Neurologia, Faculdade de Medicina - Docente
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Diagnostic accuracy of concentric needle jitter in myasthenia: Prospective study(2017) MACHADO, Flavia C. N.; KOUYOUMDJIAN, Joao A.; MARCHIORI, Paulo E.Introduction: The aim of this study was to estimate jitter parameters in the orbicularis oculi muscle using a concentric needle electrode (CNE) in patients with myasthenia gravis (MG) and to determine its diagnostic accuracy for jitter analysis (CNEMG-jitter). Methods: CNEMG-jitter was performed in 20 healthy subjects and 33MG patients using the voluntary contraction technique. Receiver operating characteristic (ROC) curves were constructed to determine cut-off points with the best sensitivity/specificity combination for jitter analysis. Results: CNEMG-jitter yielded high positivity rates for ocular MG (92.3%) and generalized MG (100%). The ROC curve cut-off point that provided the highest sensitivity without false positives was 24.7 s for mean jitter and 33.1 s for the 18th highest value. Sensitivity was 93.9% for both parameters. Diagnostic accuracy of CNEMG-jitter was>96%. Conclusions: CNEMG-jitter yielded high sensitivity and specificity rates. Our reference values were lower than previously published values, possibly due to less technical variation between the different recordings. Muscle Nerve55: 190-194, 2017
- A common CHRNE mutation (c.130dupG) in Brazilian patients with congenital myasthenic syndrome(2017) ESTEPHAN, E.; SILVA, A.; MENDONCA, R.; CALDAS, V.; ZAMBON, A.; MARCHIORI, P.; HEISE, C.; REED, U.; ZANOTELI, E.