MARCELLO ANTONIO SIGNORELLI COCUZZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
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- SARS-CoV-2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services(2021) ESTEVES, Sandro C.; LOMBARDO, Francesco; GARRIDO, Nicolas; ALVAREZ, Juan; ZINI, Armand; COLPI, Giovanni M.; KIRKMAN-BROWN, Jackson; LEWIS, Sheena E. M.; BJORNDAHL, Lars; MAJZOUB, Ahmad; CHO, Chak-Lam; VENDEIRA, Pedro; HALLAK, Jorge; AMAR, Edouard; COCUZZA, Marcello; BENTO, Fabiola C.; FIGUEIRA, Rita C.; SCIORIO, Romualdo; LAURSEN, Rita J.; METWALLEY, Ahmad M.; JINDAL, Sunil K.; PAREKATTIL, Sijo; RAMASAMY, Ranjith; ALVIGGI, Carlo; HUMAIDAN, Peter; YOVICH, John L.; AGARWAL, AshokThe prolonged lockdown of health facilities providing non-urgent gamete cryopreservation-as currently recommended by many reproductive medicine entities and regulatory authorities due to the SARS-CoV-2 pandemic will be detrimental for subgroups of male infertility patients. We believe the existing recommendations should be promptly modified and propose that the same permissive approach for sperm banking granted for men with cancer is expanded to other groups of vulnerable patients. These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto-immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. In both scenarios, the ""fertility window"" may be transitory; postponing diagnostic semen analysis and sperm banking in these men could compromise the prospects of biological parenthood. Moreover, we provide recommendations on how to continue the provision of andrological services in a considered manner and a safe environment. Our opinion is timely and relevant given the fact that fertility services are currently rated as of low priority in most countries.
- Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility(2019) AGARWAL, Ashok; PAREKH, Neel; SELVAM, Manesh Kumar Panner; HENKEL, Ralf; SHAH, Rupin; HOMA, Sheryl T.; RAMASAMY, Ranjith; KO, Edmund; TREMELLEN, Kelton; ESTEVES, Sandro; MAJZOUB, Ahmad; ALVAREZ, Juan G.; GARDNER, David K.; JAYASENA, Channa N.; RAMSAY, Jonathan W.; CHO, Chak-Lam; SALEH, Ramadan; SAKKAS, Denny; HOTALING, James M.; LUNDY, Scott D.; VIJ, Sarah; MARMAR, Joel; GOSALVEZ, Jaime; SABANEGH, Edmund; PARK, Hyun Jun; ZINI, Armand; KAVOUSSI, Parviz; MICIC, Sava; SMITH, Ryan; BUSETTO, Gian Maria; BAKIRCIOGLU, Mustafa Emre; HAIDL, Gerhard; BALERCIA, Giancarlo; PUCHALT, Nicols Garrido; BEN-KHALIFA, Moncef; TADROS, Nicholas; KIRKMAN-BROWNE, Jackson; MOSKOVTSEV, Sergey; HUANG, Xuefeng; BORGES JR., Edson; FRANKEN, Daniel; BAR-CHAMA, Natan; MORIMOTO, Yoshiharu; TOMITA, Kazuhisa; SRINI, Vasan Satya; OMBELET, Willem; BALDI, Elisabetta; MURATORI, Monica; YUMURA, Yasushi; VIGNERA, Sandro La; KOSGI, Raghavender; MARTINEZ, Marlon P.; EVENSON, Donald P.; ZYLBERSZTEJN, Daniel Suslik; ROQUE, Matheus; COCUZZA, Marcello; VIEIRA, Marcelo; BEN-MEIR, Assaf; ORVIETO, Raoul; LEVITAS, Eliahu; WISER, Amir; ARAFA, Mohamed; MALHOTRA, Vineet; PAREKATTIL, Sijo Joseph; ELBARDISI, Haitham; CARVALHO, Luiz; DADA, Rima; SIFER, Christophe; TALWAR, Pankaj; GUDELOGLU, Ahmet; MAHMOUD, Ahmed M. A.; TERRAS, Khaled; YAZBECK, Chadi; NEBOJSA, Bojanic; DURAIRAJANAYAGAM, Damayanthi; MOUNIR, Ajina; KAHN, Linda G.; BASKARAN, Saradha; PAI, Rishma Dhillon; PAOLI, Donatella; LEISEGANG, Kristian; MOEIN, Mohamed-Reza; MALIK, Sonia; YAMAN, Onder; SAMANTA, Luna; BAYANE, Fouad; JINDAL, Sunil K.; KENDIRCI, Muammer; ALTAY, Baris; PEROVIC, Dragoljub; HARLEV, AviDespite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.