CLEIDE GUIMARAES MACHADO CARANI

(Fonte: Lattes)
Índice h a partir de 2011
7
Lattes
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

search.filters.applied.f.dateIssued: 2021 ×

Resultados de Busca

Agora exibindo 1 - 3 de 3
  • conferenceObject
    Intraretinal cystoid spaces in acute Vogt-Koyanagi-Harada disease
    (2021) MISSAKA, Ruy Felippe Brito Goncalves; GOLDBAUM, Mauro; MACHADO, Cleide Guimaraes; SOUTO, Fernanda Maria Silveira; LAVEZZO, Marcelo Mendes; SAKATA, Viviane Mayumi; NOBREGA, Priscilla Figueiredo Campos; OYAMADA, Maria Kiyoko; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce H.
  • bookPart
    Oftalmopediatria
    (2021) POLATI, Mariza; MATAYOSHI, Suzana; DEBERT, Iara; GRAZIANO, Rosa Maria; MACHADO, Cleide Guimarães
  • article 7 Citação(ões) na Scopus
    Variants inHSD11B1gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes
    (2021) MORI, Rosana Cristina; SANTOS-BEZERRA, Daniele Pereira; PELAES, Tatiana Souza; ADMONI, Sharon Nina; PEREZ, Ricardo Vessoni; MONTEIRO, Maria Beatriz; MACHADO, Cleide Guimaraes; QUEIROZ, Marcia Silva; MACHADO, Ubiratan Fabres; CORREA-GIANNELLA, Maria Lucia
    Background and aim 11 beta-Hydroxysteroid dehydrogenase 1 has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association ofHSD11B1SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals. Materials and methods Five SNPs were genotyped in 466 T1D individuals (57% women; median of 37 years old, diabetes duration of 25 years and HbA1c of 8.4%). Results The minor allele T of rs11799643 was nominally associated with diabetic retinopathy (OR = 0.52; confidence interval [CI] 95% = 0.28-0.96;P= .036). The minor allele C of rs17389016 was nominally associated with overt diabetic kidney disease (DKD) (OR = 1.90; CI 95% = 1.07-3.37;P= .028). A follow-up study revealed that 29% of the individuals lost >= 5 mL min(-1)x 1.73 m(2)per year of the estimated glomerular filtration rate (eGFR). In these individuals (eGFR decliners), C allele of rs17389016 was more frequent than in non-decliners (OR = 2.10; CI 95% = 1.14-3.89;P= .018). Finally, minor allele T of rs846906 associated with higher prevalence of arterial hypertension, higher body mass index and waist circumference, thus conferring risk to a lower estimated glucose disposal rate, a surrogate marker of insulin sensitivity (OR = 1.23; CI 95% = 1.06-1.42;P= .004). Conclusion SNPs in theHSD11B1gene may confer susceptibility to DKD and to IR in T1D individuals.