ALESSANDRA CHOQUETA DE TOLEDO ARRUDA

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LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Respiratory System ×

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Agora exibindo 1 - 10 de 21
  • conferenceObject
    Long-term effects of biomass burning exposure on nasal mucociliary clearance in Brazilian sugarcane cutters
    (2013) FERREIRA-CECCATO, Aline Duarte; RAMOS, Ercy Mara Cipulo; CARVALHO JUNIOR, Luiz Carlos Soares de; CUISSI, Rafaela Campos; PESTANA, Paula Roberta da Silva; LEITE, Marceli Rocha; DAVID, Renata Marques; PEREIRA, Paulo Augusto Raymundo; PROENCA, Camila dos Anjos; TEIXEIRA, Marcos Fernando de Souza; OIKAWA, Sergio; TOLEDO, Alessandra Choqueta de; RAMOS, Dionei
  • conferenceObject
    Time course effects of exercise training on pulmonary injury induced by exposure to cigarette smoke in mice
    (2013) TOLEDO-ARRUDA, Alessandra C.; GUARNIER, Flavia; SUEHIRO, Camila L.; ALMEIDA, Francine; OLIVO, Clarice; LOPES, Fernanda; VIEIRA, Rodolfo; CAMARGO-FILHO, Jose Carlos Silva; CECCHINI, Rubens; LIN, Chin; MARTINS, Milton A.
  • article 15 Citação(ões) na Scopus
    Nasal Mucociliary Clearance in Subjects With COPD After Smoking Cessation
    (2015) ITO, Juliana T.; RAMOS, Dionei; LIMA, Fabiano F.; RODRIGUES, Fernanda M. M.; GOMES, Paulo R.; MOREIRA, Graciane L.; MACCHIONE, Mariangela; TOLEDO, Alessandra C.; RAMOS, Ercy M. C.
    BACKGROUND: Exposure to cigarette smoke causes significant impairment in mucociliary clearance (MCC), which predisposes patients to secretion retention and recurrent airway infections that play a role in exacerbations of COPD. To determine whether smoking cessation may influence MCC and frequency of exacerbations, the following groups were evaluated: ex-smokers with COPD, smokers with COPD, current smokers with normal lung function, and nonsmokers with normal lung function. METHODS: Ninety-three subjects were divided into 4 groups: ex-smokers with COPD (n = 23, 62.4 +/- 8.0 y, 13 males), smokers with COPD (n = 17, 58.2 +/- 8.0 y, 6 males), current smokers (n = 27, 61.5 +/- 6.4 y, 17 males), and nonsmokers (n = 26, 60.8 +/- 11.3 y, 7 males). MCC was evaluated using the saccharin transit time (STT) test, and the frequency of exacerbations in the last year was assessed by questionnaire. The Kruskal-Wallis test followed by Dunn's test were used to compare STT among groups, and the Goodman test was used to compare the frequency of exacerbations. RESULTS: STT of smokers with COPD (16.5 [11-28] min; median [interquartile range 25-75%]) and current smokers (15.9 110-271 min) was longer compared with ex-smokers with COPD (9.7 [6-12] min) and nonsmokers (8 [6-16] min) (P < .001). There was no difference in STT values between smokers with COPD and current smokers, and these values in ex-smokers with COPD were similar to the control group (P > .05). The frequency of exacerbations was lower in ex-smokers with COPD compared with smokers with COPD. CONCLUSIONS: One year after smoking cessation, subjects with COPD had improved mucociliary clearance.
  • conferenceObject
    Aerobic Exercise Attenuates Skeletal Muscle Injury Induced By Cigarette Smoke Exposure In Mice
    (2014) TOLEDO-ARRUDA, A. C.; SUEHIRO, C. L.; GUARNIER, F. A.; VIEIRA, R. D. P.; ALMEIDA, F. M.; LOPES, F. D.; ARANTES, P. D. M. M.; CECCHINI, R.; LIN, C. J.; MARTINS, M. D. A.
  • conferenceObject
    Sakuranetin Derived From Baccharis Retusa (asteraceae) Reduces Lung Vascular Inflammation And Remodeling Induced By Chronic Allergic Airway Inflammation
    (2013) SAKODA, C. P. P.; TOLEDO, A. C.; PINHEIRO, N. M.; PERINI, A.; GRECCO, S.; TIBERIO, I. F. L. C.; HIYANE, M. I.; CAMARA, N. O. S.; MARTINS, M. A.; LAGO, J. H. G.; PRADO, C. M.
  • conferenceObject
    Time-Course Effects Of Aerobic Exercise On Lung Mechanics And Inflammation In Mice Exposed To Cigarette Smoke
    (2013) TOLEDO, A. C.; SUEHIRO, C.; ALMEIDA, F. M.; OLIVO, C.; LOPES, F. D.; VIEIRA, R. P.; LIN, C. J.; MARTINS, M. A.
  • article 7 Citação(ões) na Scopus
    Acute Mucociliary Clearance Response to Aerobic Exercise in Smokers
    (2015) RAMOS, Ercy M. C.; VANDERLEI, Luiz Carlos M.; ITO, Juliana T.; LIMA, Fabiano F.; RODRIGUES, Fernanda M. M.; MANZANO, Beatriz M.; FERNANDES, Romulo A.; CECILIO, Michel J.; TOLEDO-ARRUDA, Alessandra C.; RAMOS, Dionei
    BACKGROUND: Mucociliary clearance is the main defense mechanism of the respiratory system, and it is influenced by several stimuli, including aerobic exercise and cigarette smoking. We evaluated the acute response of mucociliary clearance to aerobic exercise in smokers and nonsmokers compared with that found after acute smoking and smoking combined with exercise. Also, we investigated whether there was a correlation between mucociliary clearance and the autonomic nervous system under these conditions. METHODS: Twenty-one smokers were evaluated for mucociliary clearance by saccharin transit time (STT), and the response of the autonomic nervous system was evaluated by heart rate variability after aerobic exercise, after exercise followed by smoking, after acute smoking, and after rest. For comparison, 17 nonsmokers were also assessed during exercise. Repeated-measures analysis of variance with the Tukey test or the Friedman test followed by the Dunn test was used to evaluate the STT, autonomic response, and other variables to exercise and/or smoking in smokers. A paired t test or Wilcoxon test was used to analyze responses to exercise in nonsmokers. Correlations were evaluated using Pearson or Spearman coefficients. RESULTS: The STT was reduced after exercise in both groups, with similar responses between them. Other stimuli also reduced the STT. The STT showed a negative correlation with sympathetic activity in smokers and a positive correlation with the parasympathetic system in nonsmokers. CONCLUSIONS: Although impaired in smokers, mucociliary clearance responded to the stimulus of exercise, as demonstrated by similar STTs compared with nonsmokers. This response was correlated with the autonomic nervous system in both groups. In smokers, mucociliary clearance also responded to the stimuli of smoking and exercise followed by smoking.
  • conferenceObject
    Correlation between heart rate variability indexes and aerobic physiological variables in patients with COPD
    (2013) LEITE, Marceli Rocha; RAMOS, Ercy Mara Cipulo; CUISSI, Rafaela Campos; KALVA FILHO, Carlos Augusto; RODRIGUES, Fernanda Maria Machado; PESTANA, Paula Roberta da Silva; CECCATO, Aline Duarte Ferreira; CARVALHO JUNIOR, Luiz Carlos Soares de; ITO, Juliana Tiyaki; NICOLINO, Juliana; PAPOTI, Marcelo; VANDERLEI, Luiz Carlos Marques; TOLEDO, Alessandra Choqueta de; RAMOS, Dionei
  • conferenceObject
    May impairment of mucociliary clearance in COPD be reversible?
    (2013) ITO, Juliana Tiyaki; RAMOS, Dionei; LIMA, Fabiano Francisco; NICOLINO, Juliana; RODRIGUES, Fernanda Maria Machado; BRIGIDA, Gabriel Faustino Santa; DAVID, Renata Marques; XAVIER, Rafaella Fagundes; LEITE, Marceli Rocha; TOLEDO, Alessandra Choqueta; RAMOS, Ercy Mara Cipulo
  • article 14 Citação(ões) na Scopus
    Analysis of autonomic modulation after an acute session of resistance exercise at different intensities in chronic obstructive pulmonary disease patients
    (2015) NICOLINO, Juliana; RAMOS, Dionei; LEITE, Marceli Rocha; RODRIGUES, Fernanda Maria Machado; SILVA, Bruna Spolador de Alencar; TACAO, Guilherme Yassuyuki; TOLEDO, Alessandra Choqueta de; VANDERLEI, Luiz Carlos Marques; RAMOS, Ercy Mara Cipulo
    Purpose: Physical exercises are employed as part of the treatment of patients with chronic obstructive pulmonary disease (COPD); however information regarding cardiac autonomic modulation after an acute session of resistance exercise (RE) is unknown. The aim of this study was to evaluate the cardiac autonomic modulation, via heart rate variability after an acute session of RE applied at different intensities in COPD patients. Patients and methods: Twelve COPD patients underwent an acute session of RE with an intensity of 600% and another of 9000 of the one repetition maximum test. For analysis of autonomic modulation, heart rate was recorded beat-by-beat for 20 minutes at rest and after the training session. Heart rate variability indexes were obtained in the time and frequency domains for the assessment of autonomic modulation. Results: Regardless of exercise intensity, RE acute sessions influenced the autonomic modulation the recovery period was compared with the baseline. An increase in standard deviation of normal to normal RR intervals was observed throughout recovery time after the RE, as compared to baseline in both protocols: 60% and 90% of the one repetition maximum test. The spectral component of low frequency index (ms) was higher throughout recovery when compared to baseline in both protocols. The same was also observed in the spectral component of high frequency index (ms) for the protocols of 60% and 90%. Conclusion: RE sessions impact on the autonomic modulation of COPD patients by promoting differences in the recovery period compared to baseline, regardless of the intensity of the exercise performed.