LEILA ANTONANGELO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina - Líder
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
conferenceObject Evaluation of a biomarker panel for the diagnosis of cavity effusions(2018) ANTONANGELO, L.; FARIA, C. Silverio; ASCENCIO, M. M. P.; ROSOLEN, D. Cristina Batista; DOI, D.; FARIA, D. KanaanconferenceObject Performance of the UroVysion (R) FISH assay for the diagnosis of malignant effusions using two cutoff strategies(2018) ANTONANGELO, L.; FARIA, D. Kanaan; FARIA, C.; ROSOLEN, D. Cristina BatistaconferenceObject Genomic profile of primary non-small cell lung cancer and matched mediastinal lymph nodes by next-generation sequencing: a pilot study(2022) ANTONANGELO, L.; FARIA, C. S.; TERRA, R. M.; NASCIMENTO, E. C. T. do; MELLO, E. S. de; MANGONE, F. R. R.; NAGAI, M. A.; AGATI, M. E. M.; CAPELOZZI, V. L.conferenceObject Usefulness of type V collagen and alpha 2 beta 1-integrin in the cytological diagnosis of pleural liquid biopsy(2019) ANTONANGELO, L.; TEODORO, W. Rosolia; FARIA, C. Silverio; QUEIROZ, Z. A.; SILVEIRA, L. Ramos da; VELOSA, A. P.; CAPELOZZI, V.conferenceObject Multiplex Ligation Probe-dependent Amplification (MLPA) as an ancillary method for the diagnosis of malignant pleural effusion(2012) PARRA, E.; ROSOLEN, D.; KULIKOWSKI, L.; DUTRA, R.; CAPELOZZI, V. L.; VARGAS, F.; ACENCIO, M.; ANTONANGELO, L.Objective: A definitive diagnosis provided by the finding of malignant cells in pleural fluid (PF) can be established in around 50 % of patients with pleural malignancy. However, underdiagnosis risk in cytological suspicious cases is high, which makes the cytological diagnosis quite limited. This is an important clinical problem, especially if we consider that some patients, in bad clinical conditions, can not be submitted to a guided thoracoscopic biopsy. Method: Using multiplex ligation probe-dependent amplification (P315-MRC-Holland) we have studied sequence variations of EGFR gene and amplifications/deletions of chromosomal regions frequently associated to tumors (ATG4B, PAHs, PROS, NSD1, and CDGIF genes). Results: Forty-three malignant PF samples from patients with different cancers were evaluated, even in those cases with scarce pellet cells. Four benign pleural effusions were used as control. Gene sequence changes were observed in 13 (30.2 %) cases, while others copy number abnormalities were found in 19 (44.2 %). Conclusion: The findings suggest that MLPA could be considered an alternative tool to detect molecular genetic changes in malignant pleural effusions, since this technique is relatively low expensive and not time consuming. Our next challenge is to find the best combination of probes capable to recognize malignant cells of any origin in fresh samples of PF.conferenceObject Detection of aneuploidy by flow cytometry and fluorescence in situ hybridization in the diagnosis of malignant pleural effusion(2014) ROSOLEN, D.; DUTRA, A. R. N.; BOTTURA, G.; SILVA, V. M. da; CAPELOZZI, V. L.; VARGAS, F. S.; ANTONANGELO, L.conferenceObject Efficacy of the UroVysion kit for the diagnosis of malignant pleural effusion(2016) ANTONANGELO, L.; DUTRA, A. R. N.; NETO, E. Terreri; MORENA, L. C.; CAPELOZZI, V. L.; TERRA, R. M.; ROSOLEN, D. C. B.conferenceObject Frequency of genetic abnormalities in malignant pleural effusion(2016) ANTONANGELO, L.; DUTRA, A. R. N.; NETO, E. Terreri; MOREIRA, L. C.; CAPELOZZI, V. L.; TERRA, R. M.; ROSOLEN, D. C. B.conferenceObject Performance assessment of Multiplex Ligation-dependent Probe Amplification (MLPA) in malignant pleural effusions (MPE)(2019) ANTONANGELO, L.; FARIA, C. Silverio; ROCHA, R. Oliveira da; NASCIMENTO, A. Mendes; CARVALHO, G. Francisco da Silva; DIAS, A. Torchio; KULIKOWSKI, L. DomeniciconferenceObject Assessment of gDNA yield obtained from FFPE samples and from scraped histological and cytological slides of patients with lung adenocarcinoma(2022) ANTONANGELO, L.; MANGONE, F. R. R.; AGATI, M. E. M.; PAVANELLI, A. C.; NAGAI, M. A.; KULIKOWSKI, L. D.; FIGUEIREDO, V. R.; FARIA, C. S.