ALINE LOPES CHAGAS

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Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 9 de 9
  • article 1 Citação(ões) na Scopus
  • conferenceObject
    TREATMENT WITH DIRECT-ACTING ANTIVIRALS (DAAS) NEITHER INCREASES THE RISK OF HEPATOCELLULAR CARCINOMA PROGRESSION DURING WAITING LIST NOR RECURRENCE AFTER LIVER TRANSPLANTATION
    (2019) PINERO, Federico; BOIN, Ilka; RUBINSTEIN, Fernando; CHAGAS, Aline; QUINONEZ, Emilio; MARCIANO, Sebastian; VILATOBA, Mario; VARON, Adriana; ANDERS, Margarita; DUQUE, Sergio Hoyos; LIMA, Agnaldo Soares; MENENDEZ, Josemaria; PADILLA, Martin; PONIACHICK, Jaime; ZAPATA, Rodrigo; BARRABINO, Martin; MENENDEZ, Ricardo Chong; MUNOZ, Linda; ARUFE, Diego; FIGUEROA, Rodrigo; MENDIZABAL, Manuel; ZANAGA, Leticia; MACCALI, Claudia; SANDOVAL, Rodrigo Vergara; BARMUDEZ, Carla; BELTRAN, Oscar; AENAS, Isabel; GERONA, Solange; IRACHETA, Alexis; GINESTA, Alexandra; GADANO, Adrian; MATTERA, Juan; STUCCHI, Raquel; CARRILLO, Flair; SILVA, Mauricio
  • article 3 Citação(ões) na Scopus
  • conferenceObject
    SOCIODEMOGRAPHIC CHARACTERISTICS OF PATIENTS THAT AFFECT THE ADHERENCE TO HEPATOCELLULAR CARCINOMA SCREENING
    (2019) CAMARGO, Cinira Cintra; CHAGAS, Aline; ALENCAR, Regiane Saraiva De Souza Mel; TANI, Claudia Megumi; SAUD, Lisa Rodrigues Da Cunha; VEZOZZO, Denise Paranagua; COSTA, Thaisa De Fatima Almeida; MACCALI, Claudia; PINTO, Paulo Victor Alves; HORVAT, Natally; CARRILHO, Flair J.
  • conferenceObject
    LISTING, DROPOUT AND TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA IN LATIN AMERICA: UNEXPECTED AND PREVIOUSLY NOT REPORTED RESULTS
    (2019) PINERO, Federico; BOIN, Ilka; CHAGAS, Aline; QUINONEZ, Emilio; MARCIANO, Sebastian; VILATOBA, Mario; VARON, Adriana; MCCORMACK, Lucas; DUQUE, Sergio; LIMA, Agnaldo Soares; MENENDEZ, Josemaria; PADILLA, Martin; PONIACHIK, Jaime; ZAPATA, Rodrigo; MARASCHIO, Martin; MENENDE, Ricardo Chong; MUNHOZ, Linda; ARUFE, Diego; FIGUEROA, Rodrigo; CAMPANA, Ariel Gonzalez; PERALES, Simone Reges; MACCALI, Claudia; SANDOVAL, Rodrigo Vergara; BERMUDEZ, Carla; SANTOS, Luiza; BALMER, Matias; ARENAS, Isabel; GERONA, Solange; HENRIQUEZ, Victor; GINESTA, Alexandra; BARRABINO, Martin; RAFFA, Pia; GADANO, Adrian; MATTERA, Juan; ATAIDE, Elaine Cristina; CARRILHO, Flair; SILVA, Marcelo
  • conferenceObject
    A multicenter international study of sorafenib treatment in patients with hepatocellular carcinoma and chronic kidney disease undergoing hemodialysis
    (2019) DIAZ-GONZALEZ, Alvaro; SANDUZZI-ZAMPARELLI, Marco; FONSECA, Leonardo Gomes da; COSTANZO, Giovan Giuseppe Di; ALVES, Rogerio; IAVARONE, Massimo; LEAL, Cassia Regina G.; SACCO, Rodolfo; MATILLA, Ana M.; GUERRA, Manuel Hernandez; SOTERAS, Gabriel Alejandro Aballay; MARCUS, Worns; PINTER, Matthias; VARELA, Maria; LADEKARL, Morten; CHAGAS, Aline Lopes; MINGUEZ, Beatriz; RUIZ-TAPIADOR, Juan Ignacio Arenas; GRANITO, Alessandro; SANCHEZ, Yolanda; ROJAS, Angela; LOPE, Carlos Rodriguez De; ALVARES-DA-SILVA, Mario Reis; PASCUAL, Sonia; RIMASSA, Lorenza; LLEDO, Jose Luis; HUERTAS, Carlos; SANGRO, Bruno; GIANNINI, Edoardo Giovanni; DELGADO, Manuel; GOMEZ, Mercedes Vergara; PERELLO, Christie; LUE, Alberto; SALA, Margarita; MOYA, Adolfo Gallego; COLL, Susana; ALSINA, Tania Hernaez; PINERO, Federico; PEREIRA, Gustavo; FRANCA, Alex Vianey Callado; MARIN, Juan; ANDERS, Maria Margarita; MELLO, Vivianne; LOZANO, Maria Del Mar; NAULT, Jean Charles; MENENDEZ, Jose Maria; JUAREZ, Ignacio Garcia; BRUIX, Jordi; REIG, Maria
  • conferenceObject
    ANALYSIS OF PROGNOSTIC AND PREDICTIVE FACTORS OF POST RECURRENCE SURVIVAL AFTER LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA: A MULTICENTER COHORT STUDY FROM LATIN AMERICA
    (2019) PINERO, Federico; BOIN, Ilka; CHAGAS, Aline; QUINONEZ, Emilio; MARCIANO, Sebastian; VILATOBA, Mario; VARON, Adriana; ANDERS, Margarita; DUQUE, Sergio Hoyos; LIMA, Agnaldo Soares; MENENDEZ, Josemaria; PADILLA, Martin; PONIACHICK, Jaime; ZAPATA, Rodrigo; MARASCHIO, Martin; MENENDEZ, Ricardo Chong; MUNOZ, Linda; ARUFE, Diego; FIGUEROA, Rodrigo; SOZA, Alejandro; FAUDA, Martin; PERALES, Simone Reges; MACCALI, Claudia; SOZA, Alejandro; SANDOVAL, Rodrigo Vergara; BERMUDEZ, Carla; SANTOS, Luisa; ARENAS, Isabel; GERONA, Solange; MACCORMACK, Lucas; MATTERA, Juan; GADANO, Adrian; GARCIA, Jose Huygens; CARRILO, Flair; SILVA, Marcelo
  • conferenceObject
    EVALUATION OF THE AFP SCORE IN HEPATOCELLULAR CARCINOMA PROGRESSION DURING WAITING LIST AND RECURRENCE AFTER LIVER TRANSPLANTATION
    (2019) PINERO, Federico; DUVOUX, Christophe; BOIN, Ilka; CHAGAS, Aline; QUINONEZ, Emilio; MARCIANO, Sebastian; VILATOBA, Mario; VARON, Adriana; MCCORMACK, Lucas; DUQUE, Sergio Hoyos; LIMA, Agnaldo Soares; MENENDEZ, Josemaria; PADILHA, Martin; PONIACHICK, Jaime; ZAPATA, Rodrigo; MARASCHIO, Martin; MENENDEZ, Ricardo Chong; MUNOZ, Linda; FIGUEROA, Rodrigo; FAUDA, Martin; CHAIM-CORREIA, Maria Fernanda; MACCALI, Claudia; SANDOVAL, Rodrigo Vergara; BERMUDEZ, Carla; SANTOS, Luisa; ANDERS, Margarita; ARENAS, Isabel; GERONA, Solange; HENRIQUEZ, Victor; GINESTA, Alexandra; GADANO, Adrian; MATTERA, Juan; ATAIDE, Elaine; CARRILLO, Flair; SILVA, Marcelo
  • article 28 Citação(ões) na Scopus
    Hepatocellular carcinoma recurrence after liver transplantation in a Brazilian multicenter study: clinical profile and prognostic factors of survival
    (2019) CHAGAS, Aline L.; FELGA, Guilherme E. G.; DINIZ, Marcio A.; SILVA, Renato F.; MATTOS, Angelo A.; SILVA, Rita C. M. A.; BOIN, Ilka F. S. F.; GARCIA, Jose H. P.; LIMA, Agnaldo S.; COELHO, Julio C. U.; BITTENCOURT, Paulo L.; ALVES, Venancio A. F.; CHAGAS, Mine; KIKUCHI, Luciana Oba Onishi; D'AIBUQUERQUE, Luiz Augusto Carneiro; CARRILHO, Flair Jose; FELGA, Guilherme Eduardo Goncalves; ALMEIDA, Marcio Dias de; SILVA, Rita de Cassia Martins Alves da; SILVA, Renato Ferreira da; POSSATO, Mariana Bina; BOIN, Ilka de Fatima Santana Ferreira; ZANOTELLI, Maria Lucia; FERREIRA, Gustavo de Sousa Arantes; COELHO, Julio Cezar Uili; COSTA, Paulo Everton Garcia; GARCIA, Jose Huygens Parente; REICHERT, Paulo; BITTENCOURT, Paulo Lisboa; BAIA, Carlos Eduardo Sandoli; TERRABUIO, Debora Raquel Benedita; FOINQUINOS, Gabriela; CARVALHO, Sylene Coutinho Rampche de; PEREIRA, Leila Maria Moreira Beltrao; MORAES, Adriano Claudio Pereira de; WATANABE, Andre Luis Conde; LIMA, Agnaldo Soares; MATTOS, Angelo Alves de
    Background Liver transplantation (LT) is the treatment of choice for patients with unresectable early hepatocellular carcinoma (HCC). Post-LT HCC recurrence rates range from 8 to 20% and still impact on overall survival (OS). The aim of our study was to evaluate the impact of HCC recurrence on post-LT survival and analyze prognostic factors among those patients with recurrence. Patients and methods We carried out a national, multicenter, retrospective cohort study in Brazil. Medical records of 1119 LT recipients with HCC were collected. Data from patients with post-LT HCC recurrence were analyzed and correlated with post-relapse survival. Results OS of the 1119 patients included in the study was 63% over 5 years. Post-LT HCC recurrence occurred in 86 (8%) patients. The mean time to recurrence was 12 months. Sites of recurrence were extrahepatic in 55%, hepatic in 27%, and both hepatic and extrahepatic in 18%. Recurrence treatment was performed in 50 (64%) cases, mostly with sorafenib. Post-relapse survival rates were 34% at 1 year and 13% at 5 years. Univariable analysis identified alpha-fetoprotein more than 1000 ng/ml at relapse, recurrence treatment, extrahepatic location, and time to recurrence more than 2 years as prognostic factors. In multivariable analysis, recurrence treatment, extrahepatic location, and time to recurrence more than 2 years were independent predictors of better survival. Conclusion In a large Brazilian cohort of LT recipients with HCC, post-LT HCC recurrence occurred in 8% and impacted significantly on the OS. Patients with early recurrence presented a worse prognosis. However, treatment of recurrence improved outcomes, highlighting the importance of early diagnosis.