LETICIA BARBOSA KAWANO DOURADO
Projetos de Pesquisa
Unidades Organizacionais
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
13 resultados
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Agora exibindo 1 - 10 de 13
bookPart Doenças intersticiais(2015) SANTANA, Alfredo Nicodemos da Cruz; KAWANO-DOURADO, Letícia; KAIRALLA, Ronaldo AdibbookPart Fibrose Pumonar Idiopática(2016) ARAUJO, Mariana Sponholz; DOURADO, Leticia Kawano; BALDI, Bruno Guedes; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro de- Colagenose pulmão dominante em pacientes com doença pulmonar intersticial: prevalência, estabilidade funcional e manifestações extratorácicas comuns(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ALMEIDA, Guilherme Eler de; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia Barbosa; BALDI, Bruno Guedes; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeiroObjective: To describe the characteristics of a cohort of patients with lung-dominant connective tissue disease (LD-CTD). Methods: This was a retrospective study of patients with interstitial lung disease (ILD), positive antinuclear antibody (ANA) results (>= 1/320), with or without specific autoantibodies, and at least one clinical feature suggestive of connective tissue disease (CO). Results: Of the 1,998 patients screened, 52 initially met the criteria for a diagnosis of LD-CTD: 37% were male; the mean age at diagnosis was 56 years; and the median follow-up period was 48 months. During follow-up, 8 patients met the criteria for a definitive diagnosis of a CTD. The remaining 44 patients comprised the LD-CTD group, in which the most prevalent extrathoracic features were arthralgia, gastroesophageal reflux disease, and Raynaud's phenomenon. The most prevalent autoantibodies in this group were ANA (89%) and anti-SSA (anti-Ro, 27%). The mean baseline and final FVC was 69.5% and 74.0% of the predicted values, respectively (p > 0.05). Nonspecific interstitial pneumonia and usual interstitial pneumonia patterns were found in 45% and 9% of HRCT scans, respectively; 36% of the scans were unclassifiable. A similar prevalence was noted in histological samples. Diffuse esophageal dilatation was identified in 52% of HRCT scans. Nailfold capillaroscopy was performed in 22 patients; 17 showed a scleroderma pattern. Conclusions: In our LD-CTD group, there was predominance of females and the patients showed mild spirometric abnormalities at diagnosis, with differing underlying ILD patterns that were mostly unclassifiable on HRCT and by histology. We found functional stability on follow-up. Esophageal dilatation on HRCT and scleroderma pattern on nailfold capillaroscopy were frequent findings and might come to serve as diagnostic criteria.
- Uso de tiotrópio e função pulmonar em portadores de bronquiolite constritiva(2014) KAWASSAKI, Alexandre Melo; KAWANO-DOURADO, Leticia; KAIRALLA, Ronaldo Adib
- Unfavourable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis: methodological concerns(2016) KAWANO-DOURADO, Leticia; ZAMPIERI, Fernando; CAVALCANTI, Alexandre Biasi; DAMIANI, Lucas Petri; KAIRALLA, Ronaldo Adib
- Tomographic pleuropulmonary manifestations in rheumatoid arthritis: a pictorial essay(2023) BRIDI, Guilherme das Posses; SAWAMURA, Marcio Valente Yamada; WANDERLEY, Mark; SOUZA, Luciana Volpon Soares; KAIRALLA, Ronaldo Adib; KAWANO-DOURADO, Leticia; BALDI, Bruno GuedesRheumatoid arthritis ( RA) is an autoimmune inflammatory and heterogeneous disease that affects several systems, especially the joints. Among the extra- articular manifestations of RA, pleuropulmonary involvement occurs frequently, with different presentations, potentially in all anatomic thoracic compartments, and may determine high morbidity and mortality. The most common pleuropulmonary manifestations in patients with RA include interstitial lung disease (ILD), pleural disease, pulmonary arterial hypertension, rheumatoid lung nodules, airway disease (bronchiectasis and bronchiolitis), and lymphadenopathy. Pulmonary hypertension and ILD are the manifestations with the greatest negative impact in prognosis. HRCT of the chest is essential in the evaluation of patients with RA with respiratory symptoms, especially those with higher risk factors for ILD, such as male gender, smoking, older age, high levels of rheumatoid factor, or positive anti-cyclic citrullinated peptide antibody results. Additionally, other etiologies that may determine tomographic pleuropulmonary manifestations in patients with RA are infections, neoplasms, and drug-induced lung disease. In these scenarios, clinical presentation is heterogeneous, varying from being asymptomatic to having progressive respiratory failure. Knowledge on the potential etiologies causing tomographic pleuropulmonary manifestations in patients with RA coupled with proper clinical reasoning is crucial to diagnose and treat these patients.
conferenceObject Evaluation and correlations of the extension of pulmonary cysts in lymphangioleiomyomatosis(2013) ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; BALDI, Bruno Guedes; TELES, Gustavo Borges da Silva; PIMENTA, Suzana Pinheiro; PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; COSTA, Andre Nathan; KAWANO-DOURADO, Leticia; KAWASSAKI, Alexandre; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro- Brazilian guidelines for the pharmacological treatment of idiopathic pulmonary fibrosis. Official document of the Brazilian Thoracic Association based on the GRADE methodology(2020) BADDINI-MARTINEZ, Jose; FERREIRA, Juliana; TANNI, Suzana; ALVES, Luis Renato; CABRAL JUNIOR, Benedito Francisco; CARVALHO, Carlos Roberto Ribeiro; CEZARE, Talita Jacon; COSTA, Claudia Henrique da; GAZZANA, Marcelo Basso; JEZLER, Sergio; KAIRALLA, Ronaldo Adib; KAWANO-DOURADO, Leticia; LIMA, Mariana Silva; MANCUZO, Eliane; MOREIRA, Maria Auxiliadora Carmo; RODRIGUES, Marcelo Palmeira; RODRIGUES, Silvia Carla Sousa; RUBIN, Adalberto Sperb; RUFINO, Rogerio Lopes; STEIDLE, Leila John Marques; STORRER, Karin; BALDI, Bruno Guedes
- Linfadenomegalia e febre em chefe de cozinha durante viagem à Europa(2015) KAWANO-DOURADO, Leticia; PEIRERA, Daniel Antunes Silva; KAWASSAKI, Alexandre de Melo; DOLHNIKOFF, Marisa; SILVA, Marcos Vinicius da; KAIRALLA, Ronaldo AdibThis case illustrates a rare presentation (as lymphadenopathy and fever) of one of the most common zoonotic diseases worldwide brucellosis in a 22-year-old Brazilian male (a chef) who had recently returned to Brazil after having lived in and traveled around Europe for one year. The histopathology, clinical history, and response to treatment were all consistent with a diagnosis of brucellosis, which was confirmed by PCR in a urine sample. We also review some aspects of brucellosis, such as the clinical features, diagnosis, and management.
- What if my lung-dominant connective tissue disease (LD-CTD) patient eventually met criteria for a definite CTD: The role of prognosis!(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia; FREITAS, Carolina Salim; KAWASSAKI, Alexandre De Melo; GRATZIOU, Bruno; CARVALHO, Carlos R. R.; KAIRALLA, Ronaldo Adib