GRAZIELA JORGE POLIDO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Cognitive performance of children with 5q-spinal muscular atrophy: a systematic review(2018) POLIDO, G.; MIRANDA, M.; CARVAS JUNIOR, N.; CAROMANO, F.; REED, U.; ZANOTELI, E.; VOOS, M.
- Matching pairs difficulty in children with spinal muscular atrophy type I(2017) POLIDO, Graziela Jorge; BARBOSA, Alessandra Ferreira; MORIMOTO, Carlos Hitoshi; CAROMANO, Fatima Aparecida; FAVERO, Francis Meire; ZANOTELI, Edmar; REED, Umbertina Conti; VOOS, Mariana CallilThis study aimed to investigate the performance on pair-matching tasks in children with Spinal Muscular Atrophy type I (SMA-I) and the relationship between this performance and motor function, functional independence and quality of life. SMA-I (n = 12; 6.0 +/- 2.3 yrs; 9 boys, 3 girls) and control sex-, age-matched children (n = 12; 6.2 +/- 2.6 yrs) performed four pair-matching figure, number and letter tasks. The eye tracker detected eye movements. SMA-I children were assessed with CHOP INTEND, Pediatric Evaluation of Disability Inventory, and Pediatric Quality of Life Inventory. Analysis of variance showed that SMA-I children had a lower percentage of correct answers and longer timed performance compared to controls (p < 0.05). Pediatric Evaluation of Disability Inventory score (social function domain) was correlated to the percentage of correct answers on the pair-matching tasks on task 1 (r = 0.81; p = 0.001) and task 2 (r = 0.66; p = 0.020). Pair-matching performance of SMA-I children was poorer than the performance of control children. There was a relationship between pair-matching performance and social function. The restricted interaction with the environment, due to severe paralysis and poor verbal communication, is associated with cognitive difficulties in SMA-I children. The eye tracker was helpful in cognitive assessment of SMA-I children, who responded to the cognitive tests with eye movements.
- Cognitive performance of children with spinal muscular atrophy: A systematic review(2019) POLIDO, Graziela Jorge; MIRANDA, Mariana Mangini Vaz de; CARVAS JUNIOR, Nelson; MENDONÇA, Rodrigo de Holanda; CAROMANO, Fátima Aparecida; REED, Umbertina Conti; ZANOTELI, Edmar; VOOS, Mariana CallilABSTRACT Spinal muscular atrophy (SMA) is genetic and progressive, caused by large bi-allelic deletions in the SMN1 gene, or the association of a large deletion and a null variant. Objective: To evaluate the evidence about cognitive outcomes in spinal muscular atrophy (SMA). Methods: Searches on the PUBMED/Medline, Web of Knowledge and Scielo databases retrieved 26 studies (1989 to 2019, descriptors “spinal muscular atrophy” and “cognition”). Nine studies were selected according to the eligibility criteria: (1) cognition tested in individuals with SMA; (2) written in English or Spanish. The Risk of Bias in Non-Randomized Studies of Interventions was used to describe design, bias, participants, evaluation protocol and main findings. This study was registered on the International prospective register of systematic reviews (PROSPERO). Results: Three studies described normal cognition. In another three studies, cognitive outcomes were above average. Cognitive impairment was found in three studies. Poor cognitive performance was more frequently reported in studies that were recent, included children with SMA type I and that employed visual/auditory attention and executive function tests. Protocols and cognitive domains varied, precluding metanalysis. Conclusion: The severity of motor impairment may be related to cognitive outcomes: studies that included a higher number/percentage of children with SMA type I found cognitive impairment. The establishment of gold-standard protocols is necessary. Further studies should compare the cognitive outcomes of subjects with SMA types I to IV.