FERNANDA YAMAMOTO RICARDO DA SILVA

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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  • conferenceObject
    VAChT reduction increased mortality probably due to alveolar edema in a model of lung injury induced by intestinal isquemia/reperfusion in female mice
    (2017) SANTANA, Fernanda Paula Roncon; FANTOZZI, Evelyn; SILVA, Fernanda Yamamoto Ricardo da; PINHEIRO, Nathalia Montouro; TIBERIO, Iolanda de Fatima Lopes Calvo; MARTINS, Milton de Arruda; PRADO, Vania Ferreira; PRADO, Marco Antonio Maximo; LIMA, Wothan Tavares de; FALOPPA, Ana Cristina Breithaupt; PRADO, Carla Maximo
  • article 17 Citação(ões) na Scopus
    ESTRADIOL MODULATES LOCAL GUT INJURY INDUCED BY INTESTINAL ISCHEMIA-REPERFUSION IN MALE RATS
    (2017) RICARDO-DA-SILVA, Fernanda Yamamoto; FANTOZZI, Evelyn Thais; RODRIGUES-GARBIN, Sara; OLIVEIRA-FILHO, Ricardo Martins; VARGAFTIG, Bernardo Boris; BREITHAUPT-FALOPPA, Ana Cristina; LIMA, Wothan Tavares de
    Intestinal ischemia and reperfusion (I/R) triggers a systemic inflammatory response characterized by leukocyte mobilization from the bone marrow, release of cytokines to the circulation, and increased microvascular permeability, leading to high mortality. Females have shown attenuated inflammatory response to trauma when compared with males, indicatinga role for female sex hormones in this process. Here, we have evaluated the effect of estradiol on the local gut injury induced by I/R in male rats. I/R was induced by the clamping of the superior mesenteric artery for 45 min, followed by 2 h of reperfusion. Agroup received 17 beta-estradiol (280 mu g/kg, i.v., single dose) at 30 min of ischemia. Morphometric analysis of the gut showed I/R induced a reduction of villous height that was prevented by estradiol. White blood cells, notably granulocytes, were mobilized from the circulation to the intestine by I/R, which was also prevented by estradiol treatment. Groups had the intestine wrapped in a plastic bag to collect intestinal fluid, where leukocytescount, TNF-alpha, and IL-10 levels were increased by I/R. Serum chemokines (CINC-1, MIP-1 alpha, MIP-2), ICAM-1 expression in the mesenteric tissue, and neutrophils spontaneous migration measured in vitro were also increased after I/R. Estradiol treatment reduced leukocytes numbers and TNF-alpha on intestinal fluid, serum chemokine release and also downregulated MIP-1 alpha, MIP-2 gene expression, and spontaneous in vitro neutrophil migration. In conclusion, estradiol blunts intestinal injury induced by I/R by modulating chemokines release and leukocyte trafficking.
  • conferenceObject
    ESTRADIOL TREATMENT REDUCES LUNG INFLAMMATION INDUCED BY BRAIN DEATH IN FEMALE RATS
    (2017) SILVA, Fernanda Yamamoto Ricardo Da; AMSTRONG JR., Roberto; SANTOS, Marina Vidal Dos; FERREIRA, Sueli Gomes; SANNOMIYA, Paulina; MOREIRA, Luiz Felipe; BREITHAUPT-FALOPPA, Ana Cristina