FERNANDA YAMAMOTO RICARDO DA SILVA

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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  • conferenceObject
    Estradiol Modulation of Brain Death Effects on Heart Tissue in Female Rats
    (2018) ARMSTRONG JUNIOR, R.; RICARDO-DA-SILVA, F. Y.; BASILIO, L. J. L.; VIDAL, M. S.; SANNOMIYA, P.; MOREIRA, L. F. P.; BREITHAUPT-FALOPPA, A. C.
  • article 19 Citação(ões) na Scopus
    Estradiol mediates the long-lasting lung inflammation induced by intestinal ischemia and reperfusion
    (2018) FANTOZZI, Evelyn Thais; BREITHAUPT-FALOPPA, Ana Cristina; RICARDO-DA-SILVA, Fernanda Yamamoto; RODRIGUES-GARBIN, Sara; ROMERO, Daniel Cancelli; RODRIGUES, Adriana da Silva; RIFFO-VASQUEZ, Yanira; TAVARES-DE-LIMA, Wothan
    Background: Lung inflammation is one of the main consequences of intestinal ischemia reperfusion (intestinal IR) and, in severe cases, can lead to acute respiratory distress syndrome and death. We have previously demonstrated that estradiol exerts a protective effect on lung edema and cytokine release caused by intestinal IR in male rats. Materials and methods: We investigated the role of estradiol on the generation of interleukin (IL)-1 beta, IL-10, vascular endothelial growth factor (VEGF), and cytokine-induced neutrophil chemoattractant 1 (CINC-1) in a female rat model of intestinal IR. Blood and bone marrow leukocytes were also quantified. Seven-days-ovariectomized rats were subjected to intestinal IR by occlusion of the superior mesenteric artery for 45 min. After reperfusion of the tissue for 2 h, the rats were sacrificed. Lung tissue was collected, cultured for 24 h and assayed. Results: We observed a significant increase in serum levels of IL-10, CINC-1, uric acid and circulating, but not bone marrow, leukocyte numbers. In addition, intestinal IR induced a significant increase in the ex-vivo lung levels of IL-1 beta, IL-10, and VEGF. Treatment with 17b-estradiol before the induction of intestinal IR prevented the systemic release of IL-10, CINC-1, and uric acid, but it did not affect the leukocytosis. In addition, 17b-estradiol significantly prevented the ex-vivo release of IL-1b and VEGF from lung tissue. Conclusions: We demonstrated that intestinal IR interferes with lung homeostasis, priming the tissue to generate proinflammatory mediators for at least 24 h postischemia. Furthermore, our data confirm that the inflammatory responses caused by intestinal IR are estradiol mediated.
  • conferenceObject
    Positive Therapeutic Effect of Estradiol on Lung Inflammation in Brain Dead Female Rats
    (2018) SILVA, F. Yamamoto Ricardo da; ARMSTRONG JUNIOR, R.; VIDAL-DOS-SANTOS, M.; SANNOMIYA, P.; MOREIRA, L. F. P.; BREITHAUPT-FALOPPA, A. C.
  • conferenceObject
    Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice
    (2018) RIFFO-VASQUEZ, Yanira; FANTOZZI, Evelyn; RODRIGUES-GARBIN, Sara; SILVA, Fernanda Ricardo-Da; OLIVEIRA-FILHO, Ricardo; SPINA, Domenico; TAVARES-DE-LIMA, Wothan
  • article 9 Citação(ões) na Scopus
    Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice
    (2018) FANTOZZI, Evelyn Thais; RODRIGUES-GARBIN, Sara; RICARDO-DA-SILVA, Fernanda Yamamoto; OLIVEIRA-FILHO, Ricardo Martins; SPINA, Domenico; TAVARES-DE-LIMA, Wothan; RIFFO-VASQUEZ, Yanira
    Rational: Acute lung injury (ALI) is a common complication after intestinal ischemia and reperfusion (I/R) injury that can lead to acute respiratory distress syndrome (ARDS). We have previously demonstrated that females are protected against lung damage induced by intestinal I/R through an estrogen mediated mechanism. Objectives: To investigate the effect of obesity on ALI induced by intestinal I/R in female mice. Methods: C57B1/6 female mice were fed with a standard low-fat diet (SD) or a high-fat diet (HFD) for 9 weeks. Intestinal I/R injury was induced by a 45 min occlusion of the mesenteric artery followed by 2 and 24 h of reperfusion. Results: Significant increase in lung myeloperoxidase expression (MPO) and neutrophil numbers of SD and HFD mice occurred at 2 h and 24 h of reperfusion. Furthermore, HFD mice presented a significant increase in lung eosinophil peroxidase (EPO) expression and eosinophil numbers compared to SD mice. Lung wet/dry weight ratio was significantly greater in HFD mice at 2 and 24 h of reperfusion, accompanied by a significant increase in the expression of inducible NO in the lung tissue and a significant decrease in arterial oxygen saturation at 24 h of reperfusion relative to SD mice. Conclusion: Obesity predisposes female mice to increased pulmonary oedema and deterioration in gas exchange, which is accompanied by an increase in iNOS expression in the lung.