SAMUEL KATSUYUKI SHINJO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
52 resultados
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- High prevalence of fatigue in patients with Takayasu arteritis: a case-control study in a Brazilian centre(2022) SANTOS, Alexandre Moura dos; MISSE, Rafael Giovani; BORGES, Isabela Bruna Pires; SILVA, Sarah Luiza Gomes da; KIM, Ana Woo Sook; PEREIRA, Rosa Maria R.; SHINJO, Samuel KatsuyukiObjectives. Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK). Methods. This single-centre case-control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients' general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue. Results. The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0-20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P < 0.01). Moreover, TAK patients had increased fatigue rates compared with the healthy individuals (fatigue severity scale: odds ratio = 2.6; 95% CI = 1.2, 5.4; modified fatigue impact scale: odds ratio = 2.6; 95% CI = 1.2, 5.5). Fatigue was positively correlated with worsening HAQ, CRP levels, daily prednisone dose and disease activity, and negatively correlated with disease duration. Conclusion. TAK patients have a higher prevalence of fatigue, which affects different aspects of the disease, including physical function. Thus, fatigue-focused treatments should also be considered in clinical practice.
article 0 Citação(ões) na Scopus Rosa Maria Rodrigues Pereira(2022) JORGETTI, Vanda; SAMPAIO-BARROS, Percival Degrava; SHINJO, Samuel Katsuyuki; BONFA, Eloisa- Serum Myostatin and Follistatin Levels in Patients With Dermatomyositis and Polymyositis(2022) SORDI, Cintia M. de; REIS-NETO, Edgard T. dos; KEPPEKE, Gerson D.; SHINJO, Samuel K.; SATO, Emilia InoueBackground Myostatin is a protein in the TGF-beta family that negatively regulates muscle mass, and follistatin is a myostatin antagonist. Objective The aim of this study was to measure serum levels of myostatin and follistatin in idiopathic inflammatory myopathy patients and correlate these levels with muscle strength, fatigue, functional capacity, damage, and serum levels of muscle enzymes. Methods This was a multicenter cross-sectional study including 50 patients (34 dermatomyositis and 16 polymyositis [PM]) and 52 healthy individuals (control group [CG]). The disease status was evaluated according to the International Myositis Assessment & Clinical Studies. Fatigue was rated according to the Fatigue Severity Scale, and body composition was measured using dual-energy x-ray emission densitometry. Myostatin and follistatin were measured using enzyme-linked immunosorbent assays. Results Mean age was 50.9 +/- 14.0 years, and mean disease duration was 89.2 +/- 80.9 months. There were no differences in levels of myostatin (14.15 +/- 9.65 vs. 10.97 +/- 6.77 ng/mL; p = 0.131) or follistatin (0.53 +/- 0.71 vs. 0.49 +/- 0.60 ng/mL; p = 0.968) between patients and the CG. However, myostatin levels were higher in PM than CG (16.9 +/- 12.1 vs. 11.0 +/- 6.8 ng/mL; p = 0.036). There was no difference in serum myostatin among patients with and without low lean mass. Patients not treated with corticosteroids had higher serum levels of myostatin than the CG. There was a weak negative correlation between follistatin and Manual Muscle Testing and a Subset of Eight Muscles and a weak positive correlation between follistatin and Healthy Assessment Questionnaire. Conclusions Serum levels of myostatin and follistatin did not differ between dermatomyositis and PM patients and control subjects. The assessment of serum levels of myostatin and follistatin in idiopathic inflammatory myopathy patients seems not to be helpful in clinical practice.
- Reflections on the prevalence of human leukocyte antigen-B27 and human leukocyte antigen-B51 co-occurrence in patients with spondylarthritis(2022) GONCALVES, Jucier; SAMPAIO-BARROS, Percival Degrava; SHINJO, Samuel KatsuyukiWe performed a literature mini-review of the clinical profile of patients with spondylarthritis who are also human leukocyte antigen (HLA)-B51-positive. It seems to us that patients with HLA-B27 and HLA-B51 are more common in men, Asians and between the third and ninth decades of life. They are more likely to develop peripheral joint conditions, with cutaneous manifestations (e.g., oral ulcers) and uveitis. Therefore, more robust epidemiological studies with more accurate methodology and multicenter locations are needed to better map the role of the interaction between HLA-B51 in patients with spondylarthritis.
conferenceObject Short-term Safety of COVID-19 Vaccination in Systemic Sclerosis Patients: Report from a Global Patient-Reported E-survey(2022) THAKARE, Darpan; NAVEEN, R.; PAULING, John; AHMED, Sakir; WINCUP, Chris; PAPA, Nicolletta Del; SAMBATARO, Gianluca; ATZENI, Fabiola; GOVONI, Marcello; PARISI, Simone; BOCCI, Elena Bartoloni; SEBASTIANI, Gian Domenico; FUSARO, Enrico; SEBASTIANI, Marco; QUARTUCCIO, Luca; FRANCESCHINI, Franco; SAINAGHI, Pier Paolo; ORSOLINI, Giovanni; ANGELIS, Rossella De; DANIELLI, Maria Giovanna; VENERITO, Vincenzo; SEN, Parikshit; KIM, Minchul; GRACIA-RAMOS, Abraham Edgar; YOSHIDA, Akira; LILLEKER, James B.; AGARWAL, Vishwesh; KARDES, Sinan; DAY, Jessica; MILCHERT, Marcin; JOSHI, Mrudula; GHEITA, Tamer A.; SALIM, Babur; PARODIS, Ioannis; O'CALLAGHAN, Albert Selva; NIKIPHOROU, Elena; CHATTERJEE, Tulika; TAN, Ai Lyn; NUNE, Arvind; CAVAGNA, Lorenzo; SHINJO, Samuel; ZIADE, Nelly; KNITZA, Johannes; CHINOY, Hector; DISTLER, Oliver; KUWANA, Masataka; AGGARWAL, Rohit; GUPTA, Latika; AGARWAL, Vikas; MAKOL, Ashima- FACTORS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY: RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE PHYSICIAN-REPORTED REGISTRY(2022) YEOH, S. A.; GIANFRANCESCO, M.; LAWSON-TOVEY, S.; HYRICH, K.; STRANGFELD, A.; GOSSEC, L.; CARMONA, L.; MATEUS, E.; SCHAEFER, M.; RICHEZ, C.; HACHULLA, E.; HOLMQVIST, M.; SCIRE, C. A.; HASSELI, R.; JAYATILLEKE, A.; HSU, T.; D'SILVA, K.; PIMENTEL-QUIROZ, V.; MERCADO, M. Vasquez del; SHINJO, S. Katsuyuki; NETO, E. Reis; ROCHA JR., L.; MONTANDON, A. C. D. O. E. S.; JORDAN, P.; SIROTICH, E.; HAUSMANN, J.; LIEW, J.; JACOBSOHN, L.; GORE-MASSY, M.; SUFKA, P.; GRAINGER, R.; BHANA, S.; WALLACE, Z.; ROBINSON, P.; YAZDANY, J.; MACHADO, P.
- Demographic, clinical, laboratory data, prognostic, and treatment features of patients with antisynthetase syndrome: An international, two-center cohort study(2022) SILVA, L. M. B. Da; RATHORE, U.; AGARWAL, V.; GUPTA, L.; SHINJO, S. K.Objectives: To compare clinical, demographic, laboratory data, prognostic and treatment characteristics of patients with antisynthetase syndrome (ASSD) treated in two different centers of India and Brazil. Patients and methods: This international, two-center, retro-prospective cohort study which was conducted at two tertiary rheumatology centers (one in Brazil and one in India) between January 2000 to January 2020 included a total of 115 patients with ASSD (21 males, 94 females; mean age; at disease diagnosis at 40.3; range, 18 to 80 years). Demographic, clinical and laboratory data of the patients were recorded. Clinical involvement was evaluated. Results: Of the patients, 81 were Brazilians and 34 were of Indian origin. The Indian group exhibited a greater delay in diagnosis after the onset of symptoms compared to Brazilian patients (12 vs. 6 months, respectively; p=0.026). Brazilian patients exhibited a significantly higher prevalence of joint and lung involvement, mechanic’s hands, and Raynaud’s phenomenon. Anti-Jo-1 was the most common autoantibodies in both groups. Systemic arterial hypertension, followed by diabetes mellitus were the most prevalent comorbidities. Concerning previously used drugs, the Indian patients had a larger group of patients treated with antimalarials, whereas the Brazilian group used more azathioprine and intravenous immunoglobulin. A higher proportion of Indian patients was treated with one immunosuppressive drug (70.6%), while the Brazilian group were often treated using two immunosuppressive drugs (33%). Comparison between the severity and prognosis showed that Brazilian group had a higher number of relapses, and during follow-up, the global mortality rates were similar in both groups (6.2% for Brazilian vs. 8.8% for Indian). Conclusion: Brazilian and Indian patients with ASSD have comparable epidemiological characteristics such as age at the time of disease diagnosis, and sex distribution, and autoantibodies. Diagnostic delay is seen in Indian patients, and Brazilians exhibit a higher prevalence of joint and lung involvement, mechanic’s hands, Raynaud’s phenomenon with a higher number of relapses, although the mortality rate seems to be similar in both groups.
- Skeletal muscle gene expression in older adults with type 2 diabetes mellitus undergoing calorie-restricted diet and recreational sports training - a randomized clinical trial(2022) SOARES, Diana Bento da Silva; SHINJO, Samuel Katsuyuki; SANTOS, Aritania Sousa; JESUS, Joyce de Cassia Rosa de; SCHENK, Simon; CASTRO, Gabriela Salim de; ZANOTELI, Edmar; KRUSTRUP, Peter; SILVA, Maria Elizabeth Rossi da; SOUSA, Maysa Vieira deAims: This study aimed to evaluate the impact of a 12-week calorie-restricted diet and recreational sports training on gene expressions IL-15, ATROGIN-1 and MURF-1 in skeletal muscle of T2D patients. Methods: Older adults with T2D (n = 39, 60 +/- 6.0 years, BMI 33.5 +/- 0.6 kg/m(2)) were randomly allocated to Diet+Soccer (DS), Diet+Running (DR) or Diet (D). The training sessions were moderate-to-high-intensity and performed 3 x 40 min/week for 12-weeks. Gene expression from vastus lateralis muscle obtained by qRT-PCR, dual-energy X-ray and fasting blood testing measurements were performed before and after 12-weeks. Statistical analysis adopted were two-way ANOVA and Paired t-test for gene expression, and RM-ANOVA test for the remainder variables. Results: Total body weight was reduced in similar to 4 kg representing body fat mass in all groups after 12-weeks (P < 0.05). HbA1c values decreased in all groups post-intervention. Lipids profile improved in the training groups (P < 0.05) after 12-weeks. ATROGIN-1 and MURF-1 mRNA reduced in the DS (1.084 +/- 0.14 vs. 0.754 +/- 1.14 and 1.175 +/- 0.34 vs. 0.693 +/- 0.12, respectively; P < 0.05), while IL-15 mRNA increased in the DR (1.056 +/- 0.12 vs. 1.308 +/- 0.13; P < 0.05) after 12-weeks intervention. Conclusion: Recreational training with a moderate calorie-restricted diet can downregulates the expression of atrophy-associated myokines and increases the expression of anti-inflammatory gene IL-15.
- Gathering patients and rheumatologists' perceptions to improve outcomes in idiopathic inflammatory myopathies(2022) BERTOGLIO, Isabela M.; ABRAHAO, Glaucia F.; SOUZA, Fernando H. C. de; MIOSSI, Renata; MORAES, Paloma C. de; SHINJO, Samuel K.; BONFA, Eloisa; LOPES, Michelle R. UgoliniObjective: Therapeutic targets in Idiopathic Inflammatory Myopathies (IIM) are based on the opinions of physicians/specialists, which may not reflect the main concerns of patients. The authors, therefore, assessed the outcome concerns of patients with IIM and compared them with the concerns of rheumatologists in order to develop an IIM outcome standard set. Methods: Ninety-three IIM patients, 51 rheumatologists, and one physiotherapist were invited to participate. An open questionnaire was initially applied. The top 10 answers were selected and applied in a multiple-choice questionnaire, inquiring about the top 3 major concerns. Answers were compared, and the agreement rate was calculated. Concerns were gathered in an IIM outcome standard set with validated measures. Results: The top three outcome concerns raised by patients were medication side effects/muscle weakness/prevention functionality loss. The top three concerns among rheumatologists were to prevent loss of functionality/to ensure the quality of life/to achieve disease remission. Other's outcomes concerns only pointed out by patients were muscle pain/diffuse pain/skin lesions/fatigue. The agreement rate between both groups was 41%. Assessment of these parameters guided the development of an IIM standard set which included Myositis Disease Activity Assessment Visual Analogue Scale/Manual Muscle Testing/fatigue and pain Global Visual Analogue Scale/Health Assessment Questionnaire/level of physical activity. Conclusion: The authors propose a novel standard set to be pursued in IIM routine follow-up, which includes not only the main patients/rheumatologist outcome concerns but also additional important outcomes only indicated by patients. Future studies are necessary to confirm if this comprehensive approach will result in improved adherence and ultimately in better assistance.
conferenceObject Vaccine Hesitancy Among Patients with Idiopathic Inflammatory Myopathies and Rheumatic Diseases in 2021-2022: A Comparative Analysis of COVID-19 Vaccination in Autoimmune Diseases Surveys(2022) NAVEEN, R.; JOSHI, Mrudula; SEN, Parikshit; AGARWAL, Vishwesh; SHINJO, Samuel; KARDES, Sinan; LILLEKER, James B.; CHINOY, Hector; MAKOL, Ashima; DISTLER, Oliver; KIM, Minchul; NIKIPHOROU, Elena; TAN, Ai Lyn; SALIM, Babur; GHEITA, Tamer A.; ZIADE, Nelly; VELIKOVA, Tsvetelina; CHATTERJEE, Tulika; NUNE, Arvind; MILCHERT, Marcin; PARODIS, Ioannis; GRACIA-RAMOS, Abraham Edgar; O'CALLAGHAN, Albert Selva; SALINAS, Miguel Angel Saavedra; CAVAGNA, Lorenzo; KUWANA, Masataka; KNITZA, Johannes; DAY, Jessica; GUTIERREZ, Carlos Enrique Toro; CABALLERO, Carlo; DEY, Dzifa; TEHOZOL, Erick Zamora; SERRANO, Jorge Rojas; TORRE, Ignacio Garcia-De La; COLUNGA, Iris; MERAYO-CHALICO, Javier; PAULING, John; WINCUP, Chris; GASPARYAN, Armen Yuri; AGARWAL, Vikas; AGGARWAL, Rohit; GUPTA, Latika