MIRIAM VERONICA FLOR PARK

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Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: BMC Infectious Diseases ×

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  • article 2 Citação(ões) na Scopus
    Association of HIV infection with clinical and laboratory characteristics of sickle cell disease
    (2020) BELISARIO, Andre Rolim; BLATYTA, Paula F.; VIVANCO, Diana; OLIVEIRA, Claudia Di Lorenzo; CARNEIRO-PROIETTI, Anna Barbara; SABINO, Ester Cerdeira; ALMEIDA-NETO, Cesar de; LOUREIRO, Paula; MAXIMO, Claudia; MATEOS, Sheila de Oliveira Garcia; V, Miriam Flor-Park; RODRIGUES, Daniela de Oliveira Werneck; MOTA, Rosimere Afonso; GONCALEZ, Thelma T.; HOFFMANN, Thomas J.; KELLY, Shannon; CUSTER, Brian
    Background Sickle cell disease (SCD) is a multisystem disorder characterized by a wide spectrum of clinical manifestations and severity. Studies investigating potential effects of co-morbid human immunodeficiency virus (HIV) and SCD have produced conflicting results, and additional investigations are needed to elucidate whether the interaction between the two disease states might impact both HIV and SCD clinical outcomes. The association of HIV infection with clinical and laboratory characteristics of patients with SCD was assessed. Methods This nested case-control study included individuals with SCD with HIV treated at six Brazilian SCD centers. Clinical and laboratory data were abstracted from medical records. HIV positive participants were compared to age, gender, center, and SCD genotype matched HIV negative participants (ratio 1:4). Individual clinical outcomes as well as a composite outcome of any SCD complication and a composite outcome of any HIV-related complication were compared between the two groups. Results Fifteen HIV positive participants were included, 12 (80%) alive and 3 (20%) deceased. Most of the HIV positive patients had HbSS (60%;n = 9), 53% (n = 8) were female, and mean age was 30 +/- 13 years. The frequency of individual SCD complications of acute chest syndrome/pneumonia, sepsis/bacteremia, pyelonephritis, ischemic stroke, hemorrhagic stroke, abnormal transcranial Doppler (TCD), and pulmonary hypertension was higher in HIV positive participants when compared to HIV negative, although analyzed individually none were statistically significant. HIV positive participants had significantly higher risk of any SCD complication and of a composite HIV-related complication compared to the HIV negative group (HR = 4.6; 95%CI 1.1-19.6;P = 0.04 and HR = 7.7; 95%CI 1.5-40.2;P = 0.02, respectively). There was a non-significant trend towards higher risk of any infections in participants with HIV positive (HR = 3.5; 95%CI 0.92-13.4;P = 0.07). Laboratory parameters levels were not significantly different in individuals with and without HIV. Conclusions In summary, our study in SCD patients shows that those with HIV have an increased risk of any SCD complication and HIV-related complications, as well as a suggestive but not significantly increased risk of infections.