TATIANA SOUZA PELAES

(Fonte: Lattes)
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/18 - Laboratório de Carboidratos e Radioimunoensaios, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: ELAINE MARIA FRADE COSTA ×

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  • conferenceObject
    GnRH Analogue's Use in the Diagnostic Approach of Patients with Suspected 46,XX Ovotesticular Disorders of Sex Development
    (2014) PELAES, Tatiana S.; SANTANA, Nathalie Oliveira; SILVA, Rosana Barbosa; COSTA, Elaine Maria Frade; SIRCILI, Maria Helena Palma; CUNHA, Flavia Siqueira; MENDONCA, Berenice B.; DOMENICE, Sorahia
  • conferenceObject
    Successful Live Birth in a Female with 17-Hydroxylase Deficiency through IVF Frozen-Thawed Embryo Transfer after Adequate Endometrial Preparation
    (2014) BIANCHI, Paulo H. M.; GOUVEIA, Gabriela R. F. C. A.; DOMENICE, Sorahia; COSTA, Elaine M. F.; MARTIN, Regina M.; CARVALHO, Luciane C.; PELAES, Tatiana S.; CODARIN, Rodrigo R.; FARIA, Maria Beatriz S.; FRANCISCO, Rossana P. V.; BARACAT, Edmund Chada; SERAFINI, Paulo C.; MENDONCA, Berenice B.
  • article 44 Citação(ões) na Scopus
    Successful Live Birth in a Woman With 17 alpha-Hydroxylase Deficiency Through IVF Frozen-Thawed Embryo Transfer
    (2016) BIANCHI, Paulo Homem de Mello; GOUVEIA, Gabriela Romanenghi Fanti Carvalho Araujo; COSTA, Elaine M. Frade; DOMENICE, Sorahia; MARTIN, Regina M.; CARVALHO, Luciane Carneiro de; PELAES, Tatiana; INACIO, Marlene; CODARIN, Rodrigo Rocha; FARIA, Maria Beatriz Sator de; FRANCISCO, Rossana Pulcineli Vieira; BARACAT, Edmund Chada; SERAFINI, Paulo Cesar; MENDONCA, Berenice B.
    Context: Congenital adrenal hyperplasia (CAH) dueto 17 alpha-hydroxylase deficiency in 46,XX patients is characterized by primary amenorrhea, absent or incomplete sexual maturation, infertility, low serum levels of estradiol, and elevated progesterone (P). There were no previous reports of singleton live births from such women. Objective: To describe the first successful singleton live birth in a female with CAH due to 17 alpha-hydroxylase deficiency. Case Description: A 26-year-old Brazilian woman with CAH associated with 17 alpha-hydroxylase deficiency due to the compound heterozygote mutation (p.W406R/P428L) in the CYP17A1 gene expressed the desire to conceive. In vitro fertilization (IVF) was recommended due to the complexity of the disorder. The first attempt of treatment failed despite the production of viable embryos. At the second IVF attempt, all viable embryos were frozen due to inadequate endometrial development associated with prematurely elevated serum P during ovarian stimulation. Subsequently, a long-acting GnRH agonist and oral dexamethasone were used to lower ovarian and adrenal P overproduction. Once serum levels of P were < 1 ng/mL, endometrial preparation with estradiol valerate and frozen-thawed embryo transfer were performed, resulting in a singleton pregnancy. Estradiol supplementation was completely suspended by 14 weeks of gestation. She delivered at 30 weeks and 4 days due to acute fetal distress. The puerperium was uneventful; the newborn was discharged in good conditions 5 weeks after birth. Conclusion: A successful live birth was achieved in a woman with 17-hydroxylase deficiency through IVF, cryopreservation of all embryos, and frozen-thawed embryo transfer after adequate endometrial preparation.