ANGELA ESPOSITO

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  • article 4 Citação(ões) na Scopus
    The role of respiratory virus infection in suspected pertussis: A prospective study
    (2021) FERRONATO, Angela Esposito; LEITE, Daniela; VIEIRA, Sandra Elisabete
    Background: Infections caused by Bordetella pertussis are frequent and responsible for cases of huge severity in unvaccinated young infants. However, clinical manifestations vary and mimic other respiratory diseases as respiratory viruses. Methods: A prospective cohort study was performed with infants under 1 old, hospitalized with suspected pertussis. All infants were submitted to etiological research to identify Bordetella pertussis (nasopharynx swab for culture and/or PCR) and respiratory viruses (nasopharyngeal aspirate for indirect immunofluorescence). Clinical and demographic data were collected. Results: Among 59 infants, an etiological agent was identified in 37 (62.8%). Respiratory virus was identified in 19 (32%) and Bordetella pertussis in 14 (23.7%) as sole agent. Codetection was found in 4 (7%). Younger age, absence of fever, lack of BP immunization, leukocytosis > 20,000/mm3, lymphocytosis >10,000/mm3 were associated to a greater chance of pertussis. Wheezing and living with siblings were associated with viral infection. After adjustment for confounders, the most important predictors were presence of wheezing for respiratory virus and leukocytosis for pertussis. The severity of infections by RV and BP were similar. Conclusion: Respiratory virus infections are frequent in cases of clinical suspicion of pertussis and may actually exceed the prevalence of BP. Clinical/laboratory characteristics may suggest the etiology, but they are not pathognomonic, which stresses the need for respiratory virus and Bordetella pertussis research in this clinical situation.
  • article 46 Citação(ões) na Scopus
    Severity of viral coinfection in hospitalized infants with respiratory syncytial virus infection
    (2011) PAULIS, Milena De; GILIO, Alfredo Elias; FERRARO, Alexandre Archanjo; FERRONATO, Angela Esposito; SACRAMENTO, Patricia Rossi do; BOTOSSO, Viviane Fongaro; OLIVEIRA, Danielle Bruna Leal de; MARINHEIRO, Juliana Cristina; HARSI, Charlotte Marianna; DURIGON, Edison Luiz; VIEIRA, Sandra Elisabete
    Objective: To compare the severity of single respiratory syncytial virus (RSV) infections with that of coinfections. Methods:A historical cohort was studied, including hospitalized infants with acute RSV infection. Nasopharyngeal aspirate samples were collected from all patients to detect eight respiratory viruses using molecular biology techniques. The following outcomes were analyzed: duration of hospitalization and of oxygen therapy, intensive care unit admission and need of mechanical ventilation. Results were adjusted for confounding factors (prematurity, age and breastfeeding). Results: A hundred and seventy six infants with bronchiolitis and/or pneumonia were included in the study. Their median age was 4.5 months. A hundred and twenty one had single RSV infection and 55 had coinfections (24 RSV + adenovirus, 16 RSV + human metapneumovirus and 15 other less frequent viral associations). The four severity outcomes under study were similar in the group with single RSV infection and in the coinfection groups, independently of what virus was associated with RSV. Conclusion: Virus coinfections do not seem to affect the prognosis of hospitalized infants with acute RSV infection.