JOSE MARIANI JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
22 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 22
bookPart Cineangiocoronariografia e métodos diagnósticos complementares(2016) MARIANI JUNIOR, José; LEMOS NETO, Pedro AlvesconferenceObject Head-to-head comparison between coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS) tridimensional models: a geometric point of view(2016) BEZERRA, Cristiano G.; TALOU, Gonzalo Maso; BULANT, Carlos A.; MARIANI JR., Jose; PINTON, Fabio A.; FALCAO, Breno A. A.; FILHO, Antonio E.; FEIJOO, Raul A.; LEMOS, Pedro A.; BLANCO, Pablo J.- Validation of coronary computed tomography angiography scores for non-invasive assessment of atherosclerotic burden through a comparison with multivessel intravascular ultrasound(2016) CAVALCANTE, Rafael; BITTENCOURT, Marcio S.; PINHEIRO, Thais L.; FALCAO, Breno A. A.; MORAIS, Gustavo R.; SOARES, Paulo; MARIANI JR., Jose; RIBEIRO, Expedito; KALIL-FILHO, Roberto; ROCHITTE, Carlos E.; LEMOS, Pedro A.Aims: While the atherosclerotic plaque volume can be manually quantified in coronary computed tomography angiography (CTA) it is impractical for clinical routine use. Several anatomical scores have been developed as surrogates for overall atherosclerotic burden in coronary CTA and even proven to be highly predictive for future adverse events. However, they have not been validated against the gold standard for atherosclerotic burden, intra-vascular ultrasound (IVUS). In the present study we have compared several coronary CTA scores with the coronary IVUS. Methods and results: A total of 62 patients with diagnosed coronary disease scheduled for percutaneous intervention were prospectively enrolled. For all patients, coronary CTA and multivessel IVUS were obtained. Calcium score and 6 previously reported scores were calculated from coronary CTA imaging and compared to average IVUS-derived percent atheroma volume (PAV). On average, 3.8 +/- 0.7 vessels, comprising 123.8 +/- 31.3 mm in length, were imaged with IVUS per patient. All but one previously described scoring systems showed a significant association with IVUS-derived PAV. Among them, the SSS score demonstrated the strongest correlation with IVUS-PAV (r = 0.61, p < 0.001) and the greatest area under the ROC curve (C-statistic = 0.87), to predict a high PAV. Conclusions: Most frequently used coronary CTA scores have a good correlation with global coronary atherosclerotic burden measured by multivessel IVUS derived atheroma volume. Among them, the SSS score shows the best performance being a good non-invasive alternative to IVUS for global coronary atherosclerotic burden assessment.
- Renal denervation in patients with heart failure secondary to Chagas' disease: A pilot randomized controlled trial(2019) SPADARO, Andre G.; BOCCHI, Edimar A.; SOUZA, Germano E.; FILHO, Antonio E.; MARIANI JR., Jose; CAMPOS, Carlos M.; LEMOS, Pedro A.Introduction Chagas disease is one of the most relevant endemic parasitic diseases in Latin America, affecting approximately 6 million people. Overt Chagas heart disease is an ominous condition, occurring in 20-30% of infected individuals, which has besides the persistent myocarditis a peculiar intracardiac ganglionic neuronal depletion and dysautonomy. This study aims to evaluate the safety and feasibility of renal denervation for patients with advanced symptomatic Chagas cardiomyopathy. Methods Open-label prospective pilot study that randomized patients with Chagas heart disease to either renal denervation or conservative treatment (2:1 ratio). The primary endpoint was the incidence of major adverse events at 9 months, defined as a composite of all-cause death, myocardial infarction, stroke, need for renal artery invasive treatment, or worsening renal function. Results A total of 17 patients were allocated for renal denervation (n = 11) or conservative treatment (n = 6). Included patients had severe symptomatic heart disease, with markedly depressed left ventricular function (average ejection fraction 26.7 +/- 4.9%). For patients randomized to renal denervation, the procedure was performed successfully and uneventfully. After 9 months, the primary endpoint occurred in 36.4% of patients in the renal denervation group and 50.0% in the control arm (p = .6). After 9 months, clinical, laboratory, functional, echocardiographic, and quality of life parameters were similar between groups. Conclusions This pilot study suggests that renal denervation is safe and feasible in patients with Chagas cardiomyopathy, warranting future studies to better evaluate the clinical efficacy of the interventional strategy in improving the prognosis of this high-risk population.
conferenceObject Computational fractional flow reserve derived from three-dimensional intravascular ultrasound: a new algorithm of fusion between anatomy and physiology(2017) BEZERRA, Cristiano; PINTON, Fabio A.; FALCAO, Breno; MARIANI JR., Jose; BULANT, Carlos A.; TALOU, Gonzalo; ESTEVES, Antonio Esteves Filh; BLANCO, Pablo; LEMOS, Pedro A.- Comparison between fractional flow reserve (FFR) and Computational fractional flow reserve derived from three-dimensional intravascular ultrasound (FFR-IVUS), percentage of diameter stenosis by visual estimation and bi-dimensional quantitative coronary angiography.(2018) HIDEO-KAJITA, Alexandre; GARCIA-GARCIA, Hector; BEZERRA, Cristiano; PINTON, Fabio A.; FALCAO, Breno; MARIANI JR., Jose; BULANT, Carlos; TALOU, Gonzalo Maso; ESTEVES, Antonio Esteves Filh; BLANCO, Pablo; LEMOS, Pedro A.
conferenceObject Quantifying Total Atherosclerotic Burden Non-Invasively Through Coronary Computed Tomography Angiography: A Comparison With Multivessel Intravascular Ultrasound Data(2014) SILVA, Rafael C.; LIMA, Thais P.; FALCAO, Breno A.; MORAIS, Gustavo R.; SPADARO, Andre G.; MARIANI, Jose; RIBEIRO, Expedito E.; KALIL, Roberto; ROCHITTE, Carlos E.; LEMOS, Pedro A.- Validation of Computed Tomography-Leaman Score for Risk Assessment of Patients Treated by Percutaneous Coronary Intervention(2018) KIM, Simone; CAMPOS, Carlos; CAIXETA, Adriano; LEMOS, Pedro A.; FRANKEN, Marcelo; MARIANI JR., Jose
conferenceObject Evaluation of Renal Function Improvement After Transcatheter Aortic Valve Replacement(2017) SILVA, Michel Lemes da; NUNES FILHO, Antonio Carlos Bacelar; CAIXETA, Adriano; RIBEIRO, Henrique; ESTEVES, Natalia; ALMEIDA, Breno; MARIANI JR., Jose; CAMPOS, Carlos; PEREIRA, Carolina; PRADO, Rogerio Ruscitto; FRANKEN, Marcelo; TARASOUTCHI, Flavio; LEMOS, Pedro A.; BRITO JR., FabioconferenceObject Predictors of renal function improvement in patients with chronic kidney disease undergoing TAVR(2019) LEMES, M. V. S.; BACELAR, A. C.; ROSA, V. E. E.; CAIXETA, A. M.; LEMOS, P. A.; RIBEIRO, H. B.; ALMEIDA, B. O.; MARIANI, J.; CAMPOS, C. A. H. M.; TARASOUTCHI, F.; FRANKEN, M.; BRITO, F. S.
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