CELSO RICARDO FERNANDES DE CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina - Docente
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina - Líder
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Interventions to Increase Physical Activity in Middle-Age Women at the Workplace: A Randomized Controlled Trial(2014) RIBEIRO, Marcos Ausenka; MARTINS, Milton Arruda; CARVALHO, Celso R. F.Purpose A four-group randomized controlled trial evaluated the impact of distinct workplace interventions to increase the physical activity (PA) and to reduce anthropometric parameters in middle-age women. Methods One-hundred and ninety-five women age 40-50 yr who were employees from a university hospital and physically inactive at their leisure time were randomly assigned to one of four groups: minimal treatment comparator (MTC; n = 47), pedometer-based individual counseling (PedIC; n = 53), pedometer-based group counseling (PedGC; n = 48), and aerobic training (AT; n = 47). The outcomes were total number of steps (primary outcome), those performed at moderate intensity (>= 110 steps per minute), and weight and waist circumference (secondary outcomes). Evaluations were performed at baseline, at the end of a 3-month intervention, and 3 months after that. Data were presented as delta [(after 3 months-baseline) or (after 6 months-baseline)] and 95% confidence interval. To detect the differences among the groups, a one-way ANOVA and a Holm-Sidak post hoc test was used (P < 0.05). The Cohen effect size was calculated, and an intention-to-treat approach was performed. Results Only groups using pedometers (PedIC and PedGC) increased the total number of steps after 3 months (P < 0.05); however, the increase observed in PedGC group (1475 steps per day) was even higher than that in PedIC (512 steps per day, P < 0.05) with larger effect size (1.4). The number of steps performed at moderate intensity also increased only in the PedGC group (845 steps per day, P < 0.05). No PA benefit was observed at 6 months. Women submitted to AT did not modify PA daily life activity but reduced anthropometric parameters after 3 and 6 months (P < 0.05). Conclusions Our results show that in the workplace setting, pedometer-based PA intervention with counseling is effective increasing daily life number of steps, whereas AT is effective for weight loss.
conferenceObject Comparison Between Aerobic And Breathing Exercises On Clinical Control And Psychosocial Morbidity In Severe Asthmatics(2014) SACCOMANI, Milene G.; EVARISTO, Karen B.; CUKIER, Alberto; STELMACH, Rafael; CARVALHO-PINTO, Regina; ROJO, Marcos; SANTAELLA, Danilo F.; MARTINS, Milton A.; CARVALHO, Celso R. F.- Post-Walking Exercise Hypotension in Patients with Intermittent Claudication(2015) CUCATO, Gabriel Grizzo; CHEHUEN, Marcel Da Rocha; RITTI-DIAS, Raphael Mendes; CARVALHO, Celso Ricardo Fernandes; WOLOSKER, Nelson; SAXTON, John Michael; FORJAZ, Claudia Lucia De MoraesPurpose: This study aimed to investigate the acute effect of intermittent walking exercise (WE) on blood pressure (BP) responses in patients with intermittent claudication (IC). Secondly, this study aimed to gain improved insight into the physiological mechanisms controlling BP regulation after intermittent WE in this patient group. Methods: Twenty patients with IC participated in two experimental sessions in a random order, as follows: WE (15 x 2-min bouts of WE interpolated with 2-min rest intervals) and control (standing rest on a treadmill for 60 min). BP, cardiac output (CO: CO2 rebreathing), and cardiovascular autonomic modulation (spectral analysis of HR variability) were assessed before and after both experimental sessions during supine rest, and stroke volume (SV) and systemic vascular resistance (SVR) were calculated. Data were analyzed using two-way ANOVA. Results: WE decreased systolic, diastolic, and mean BP, with net effects of -13 +/- 2, -5 +/- 2, and -7 +/- 2 mm Hg versus control, respectively (all P < 0.05). WE also decreased SV (-5.62 +/- 1.97 mL, P < 0.05) and CO (-0.05 +/- 0.13 LImin(-1), P < 0.05) versus preintervention and prevented the observed increase in SVR in the control condition (+4.2 +/- 1.4 U, P < 0.05). HR showed a decrease (P < 0.05), consistent with evidence of increased vagal modulation, in the control condition. BP measurements over the subsequent 24 h were similar between experimental conditions. Conclusions: In patients with IC, WE induced a postexercise hypotension response that had a significant magnitude versus control but was not maintained over the next 24 h of daily activities. The acute postexercise hypotension response wasmediated by a decrease in CO and SV, which was not compensated by an augmentation of SVR, as observed in the control arm of the study.
- Exercise Improves Physical Activity and Comorbidities in Obese Adults with Asthma(2018) FREITAS, Patricia Duarte; SILVA, Aline Grandi; FERREIRA, Palmira Gabriele; SILVA, Analuci Da; SALGE, Joao Marcos; CARVALHO-PINTO, Regina Maria; CUKIER, Alberto; BRITO, Claudia M.; MANCINI, Marcio C.; CARVALHO, Celso R. F.Introduction Obese adults with asthma have an increased number of comorbidities and reduced daily life physical activity (DLPA), which may worsen asthma symptoms. Exercise is recommended to improve asthma outcomes; however, the benefits of exercise for psychosocial comorbidities and physical activity levels in obese adults with asthma have been poorly investigated. Objective This study aimed to assess the effects of exercise on DLPA, asthma symptoms, and psychosocial comorbidities in obese adults with asthma. Methods Fifty-five grade II obese adults with asthma were randomly assigned to either a weight loss program + exercise program (WL + E group, n = 28) or a weight loss program + sham (WL + S group, n = 27). The WL + E group incorporated aerobic and resistance muscle training into the weight loss program (nutrition and psychological therapies), whereas the WL + S group performed breathing and stretching exercises. DLPA, asthma symptoms, sleep quality, and anxiety and depression symptoms were quantified before and after treatment. Results After 3 months, the WL + E group presented a significant increase in daily step counts (3068 2325 vs 729 +/- 1118 steps per day) and the number of asthma symptom-free days (14.5 +/- 9.6 vs 8.6 +/- 11.4 dmonth(-1)) compared with the WL + S group. The proportion of participants with improvements in depression symptoms (76.4% vs 16.6%) and a lower risk of developing obstructive sleep apnea (56.5% vs 16.3%) was greater in the WL + E group than that in the WL + S group (P < 0.05). Significant improvements in sleep efficiency (6.6% +/- 5.1% vs 1.3% +/- 4.7%) and latency (-3.7 +/- 5.9 vs 0.2 +/- 5.6 min) were also observed in the WL + E group. Conclusions Our results strongly suggest that exercise training plus a weight loss program improves DLPA, sleep efficiency, and depression and asthma symptoms in obese adults with asthma.
- Effects of Aerobic Training on Airway Inflammation in Asthmatic Patients(2011) MENDES, Felipe Augusto Rodrigues; ALMEIDA, Francine Maria; CUKIER, Alberto; STELMACH, Rafael; JACOB-FILHO, Wilson; MARTINS, Milton A.; CARVALHO, Celso Ricardo FernandesMENDES, F. A. R., F. M. ALMEIDA, A. CUKIER, R. STELMACH, W. JACOB-FILHO, M. A. MARTINS, and C. R. F. CARVALHO. Effects of Aerobic Training on Airway Inflammation in Asthmatic Patients. Med. Sci. Sports Exerc., Vol. 43, No. 2, pp. 197-203, 2011. Purpose: There is evidence suggesting that physical activity has anti-inflammatory effects in many chronic diseases; however, the role of exercise in airway inflammation in asthma is poorly understood. We aimed to evaluate the effects of an aerobic training program on eosinophil inflammation (primary aim) and nitric oxide (secondary aim) in patients with moderate or severe persistent asthma. Methods: Sixty-eight patients randomly assigned to either control (CG) or aerobic training (TG) groups were studied during the period between medical consultations. Patients in the CG (educational program + breathing exercises; N = 34) and TG (educational program + breathing exercises + aerobic training; N = 34) were examined twice a week during a 3-month period. Before and after the intervention, patients underwent induced sputum, fractional exhaled nitric oxide (FeNO), pulmonary function, and cardiopulmonary exercise testing. Asthma symptom-free days were quantified monthly, and asthma exacerbation was monitored during 3 months of intervention. Results: At 3 months, decreases in the total and eosinophil cell counts in induced sputum (P = 0.004) and in the levels of FeNO (P = 0.009) were observed after intervention only in the TG. The number of asthma symptom-free days and (V) over dotO(2max) also significantly improved (P < 0.001), and lower asthma exacerbation occurred in the TG (P < 0.01). In addition, the TG presented a strong positive relationship between baseline FeNO and eosinophil counts as well as their improvement after training (r = 0.77 and r = 0.9, respectively). Conclusions: Aerobic training reduces sputum eosinophil and FeNO in patients with moderate or severe asthma, and these benefits were more significant in subjects with higher levels of inflammation. These results suggest that aerobic training might be useful as an adjuvant therapy in asthmatic patients under optimized medical treatment.
- Patients With Moderate And Severe Asthma Are Physically Actives, But Present Poor Aerobic Fitness(2016) SILVA, Ronaldo Aparecido; ROCCO, Patricia Goncalves Leite; MAZZUCATTO, Flvio; CUKIER, Alberto; STELMACH, Rafael; MARTINS, Milton Arruda; CARVALHO, Celso Ricardo Fernandes