PAULO MANUEL PEGO FERNANDES

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/61 - Laboratório de Pesquisa em Cirurgia Torácica, Hospital das Clínicas, Faculdade de Medicina - Líder

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Assunto: Medicine, General & Internal ×

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Agora exibindo 1 - 10 de 78
  • article 0 Citação(ões) na Scopus
    Great expectations
    (2012) PEGO-FERNANDES, Paulo Manuel; BIBAS, Benoit Jacques
  • article 0 Citação(ões) na Scopus
    Prolonged survival after thoracic metastasectomy in patients with nonseminomatous testicular cancer
    (2024) FONINI, Jaqueline Schaparini; ARAUJO, Pedro Henrique Xavier Nabuco de; 'AMBROSIO, Paula Duarte D.; SALERNO, Juliana Vieira de Oliveira; CIARALO, Pedro Prosperi Desenzi; TERRA, Ricardo Mingarini; PE, Paulo Manuel
    Introduction: Almost 20 % of patients with Non-Seminomatous Germinative Cell Tumors (NSGCT) will require intrathoracic metastasectomy after chemotherapy. The authors aim to determine their long-term survival rates. Methods: Retrospective study including patients with NSGCT and intrathoracic metastasis after systemic therapy from January 2011 to June 2022. Treatment outcomes and overall survival were analyzed with the Kaplan-Meier method. Results: Thirty-seven male patients were included with a median age of 31.8 years. Six presented with synchronous mediastinum and lung metastasis, nine had only lung, and 22 had mediastinal metastasis. Over half had retroperitoneal lymph node metastasis. Twenty-two had dissimilar pathologies, with a discordance rate of 62 %. Teratoma and embryonal carcinoma were the prevalent primary tumor types, 40.5 % each, while teratoma was predominant (70.3 %) in the metastasis group. Thoracotomy was the main surgical approach (39.2 %) followed by VATS (37.2 %), cervico-sternotomy (9.8 %), sternotomy (5.8 %), and clamshell (3.9 %). Lung resection was performed in 40.5 % of cases. Overall, 10-year survival rates were 94.3 % with no surgical-related mortality. Conclusion: Multimodality treatment with systemic therapy followed by radical surgery offers a high cure rate to patients with intrathoracic metastatic testicular germ cell tumors.
  • article 1 Citação(ões) na Scopus
  • article 1 Citação(ões) na Scopus
    Smartphones and health promotion
    (2014) MARIANI, Alessandro Wasum; PEGO-FERNANDES, Paulo Manuel
  • article 0 Citação(ões) na Scopus
    Robotic surgery training
    (2023) ARAUJO, Pedro Henrique Xavier Nabuco de; PEGO-FERNANDES, Paulo Manuel
  • article 0 Citação(ões) na Scopus
    Global Health Governance: a rising challenge
    (2013) MARIANI, Alessandro Wasum; PEGO-FERNANDES, Paulo Manuel
  • article 0 Citação(ões) na Scopus
    Healthcare systems: what do we want?
    (2011) PEGO-FERNANDES, Paulo Manuel; BIBAS, Benoit Jacques
  • article 1 Citação(ões) na Scopus
    Surgical treatment of heart failure: a hot topic
    (2011) PEGO-FERNANDES, Paulo Manuel; MONTEIRO, Rosangela
  • article 4 Citação(ões) na Scopus
    Pulmonary emphysema induced by methylphenidate: experimental study
    (2015) RAPELLO, Gabriel Victor Guimaraes; ANTONIOLLI, Andreia; PEREIRA, Daniel Martins; FACCO, Gilberto; PEGO-FERNANDES, Paulo Manuel; PAZETTI, Rogerio
    CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate. DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university. METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm). RESULTS: The Lm was greater in MP 0.8 (47.91 +/- 3.13; P < 0.01) and MP 1.2 (46.36 +/- 4.39; P < 0.05) than in the control group (40.00 +/- 3.48). CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.
  • article 3 Citação(ões) na Scopus
    Respiratory failure after lung transplantation: extracorporeal membrane oxygenation as a rescue treatment
    (2012) PEGO-FERNANDES, Paulo Manuel; HAJJAR, Ludhmila Abrahao; GALAS, Filomena Regina Barbosa Gomes; SAMANO, Marcos Naoyuki; RIBEIRO, Alexandre Kazantzi Fonseca; PARK, Marcelo; SOARES, Rodolfo; OSAWA, Eduardo; JATENE, Fabio Biscegli