MARISA DOLHNIKOFF
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina - Docente
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
8 resultados
Resultados de Busca
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conferenceObject Remodeling of bronchial and pulmonary muscular arteries in mild/moderate COPD(2014) ANNONI, Raquel; LANCAS, Tatiana; SILVA, Luiz Fernando; BRUNO, Andreina; BATTAGLIA, Salvatore; DOLHNIKOFF, Marisa; HIEMSTRA, Pieter; STERK, Peter; RABE, Klaus; MAUAD, Thais- Immunopathological aspects of schistosomiasis-associated pulmonary arterial hypertension(2014) MAUAD, Thais; POZZAN, Geanette; LANCAS, Tatiana; OVERBEEK, Maria J.; SOUZA, Rogerio; JARDIM, Carlos; DOLHNIKOFF, Marisa; MELLO, George; PIRES-NETO, Ruy Camargo; BERNARDI, Fabiola del Carlo; GRUNBERG, KatrienObjectives: Pulmonary hypertension is a lethal complication of chronic hepatosplenic schistosomiasis. Little is known of the underlying (immuno-)histopathological characteristics of lung vasculopathy. Methods: We characterized vasculopathy and inflammation in lung tissue of 10 patients with Schistosomiasis-associated PH (SCH-PH) in comparison to 22 idiopathic pulmonary arterial hypertension (IPAH) patients and 10 normal controls. SCH-PH cases were younger than controls. Results: Plexiform lesions and/or angiomatoid lesions were found in 10/10 SCH-PH, and 19/22 IPAH patients (chi(2) p = 0.22). Lung granulomas with Schistosoma eggs were found in 2/10 of SCH-PH cases. PAH cases had increased peri-arterial density of CD3+ T cells, chymase+ and tryptase+ mast cells when compared to controls (p <= 0.047). SCH-PH showed increased density of CD4+ cells when compared to controls (p = 0.025), paralleled by an increased density of dendritic CD83+ cells when compared to both controls and IPAH patients (p <= 0.022). Conclusion: Both SCH-PH and IPAH feature plexogenic arteriopathy and increased periarterial T cell and mast cell density. SCH-PH and IPAH differ only with respect to the density of dendritic CD83+ cells. These findings imply ongoing antigenic stimulation in SCH-PH, yet a pattern of pulmonary vasculopathy similar to IPAH, suggestive of a final common pathway in their pathogenesis of PAH.
conferenceObject Acute Fulminant Respiratory Failure In A Young Man: An Unexpected Diagnosis After Necropsy(2014) AYRES, P. P. M. R.; OTAKE, T. M.; ALVES JUNIOR, J. L.; LEITE, R. F.; ROCHA NETO, O. G.; CARVALHO, C. R. R.; DOLNIKHOFF, M.; BARBAS, C. S. V.conferenceObject Expression of water and ion channels proteins in acute respiratory distress syndrome from different etiologies(2014) PIRES-NETO, Ruy; NASCIMENTO, Ellen; SOUZA, Joao; RODRIGUES, Alfredo; BERNARDI, Fabiola; MAUAD, Thais; SILVA, Luiz; DOLHNIKOFF, MarisaconferenceObject Immunohistological Features Related To Lung Fuction Abnormalities In Lymphangioleiomyomatosis(2014) NASCIMENTO, E. T.; BALDI, B. G.; PIMENTA, S. P.; ANNONI, R.; MARIANI, A. W.; KAIRALLA, R. A.; BERNARDI, F. D. C.; CARVALHO, C. R.; DOLHNIKOFF, M.conferenceObject Versican, tenascin, periostin and IL-17A+cells in severe asthma(2014) MAUAD, Thais; FERREIRA, Diogenes S.; ANNONI, Raquel; OLIVEIRA, Bianca L.; KATAYAMA, Edgard H.; CARVALHO-PINTO, Regina M.; RABE, Klaus F.; CUKIER, Alberto; STELMACH, Rafael; DOLHNIKOFF, MarisaconferenceObject CD8+T cells, dendritic cells, mast cells and FOXP3 in the lungs of patients with severe influenza A (H1N1) infection(2014) BUTTIGNOL, Monique; PIRES-NETO, Ruy; BALLARIN, Marina; DOLHNIKOFF, Marisa; MAUAD, ThaisconferenceObject AIRWAY REMODELING DIFFERENTIATES ALLERGIC FROM NONALLERGIC SEVERE ASTHMA(2014) FERREIRA, Diogenes S.; ANNONI, Raquel; CARVALHO-PINTO, Regina M.; KATAYAMA, Edgard H.; FRARI, Heloisa S. Del; OLIVEIRA, Bianca L.; RABE, Klaus F.; CUKIER, Alberto; STELMACH, Rafael; DOLHNIKOFF, Marisa; MAUAD, Thais