ROBERTO HEGG

(Fonte: Lattes)
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Lattes
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Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina

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  • conferenceObject
    Abemaciclib combined with adjuvant endocrine therapy in patients with high risk early breast cancer who received neoadjuvant chemotherapy (NAC).
    (2021) MARTIN, Miguel; HEGG, Roberto; KIM, Sung-Bae; SCHENKER, Michael; GRECEA, Daniela; GARCIA-SAENZ, Jose A.; PAPAZISIS, Konstantinos; OUYANG, Quchang; LACKO, Aleksandra; OKSUZOGLU, Berna; REEVES, James Andrew; OKERA, Meena; TESTA, Laura; SHIMIZU, Chikako; WEI, Ran; FORRESTER, Tammy D.; MUNOZ, Maria; ZIMMERMANN, Annamaria H.; HEADLEY, Desiree; JOHNSTON, Stephen R. D.
  • conferenceObject
    nextMONARCH: Final overall survival analysis of abemaciclib monotherapy or in combination with tamoxifen in patients with HR+, Her2-metastatic breast cancer
    (2021) HUOBER, J.; HAMILTON, E.; CORTES, J.; OZYILKAN, O.; CHEN, S. C.; PETRAKOVA, K.; MANIKHAS, A.; JERUSALEM, G.; HEGG, R.; CHAPMAN, S.; YANG, Z.; CHEN, Y.; JOHNSTON, E.; MARTIN, M.
  • article 22 Citação(ões) na Scopus
    nextMONARCH: Abemaciclib Monotherapy or Combined With Tamoxifen for Metastatic Breast Cancer
    (2021) HAMILTON, Erika; CORTES, Javier; OZYILKAN, Ozgur; CHEN, Shin-Cheh; PETRAKOVA, Katarina; MANIKHAS, Aleksey; JERUSALEM, Guy; HEGG, Roberto; HUOBER, Jens; CHAPMAN, Sonya C.; LU, Yi; HARDEBECK, Molly C.; BEAR, Melissa M.; JOHNSTON, Erica L.; MARTIN, Miguel
    nextMONARCH investigated abemaciclib monotherapy and abemaciclib combined with tamoxifen. Patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer (MBC) were treated with abemaciclib (with or without prophylactic loperamide) and combined with tamoxifen for endocrine refractory MBC after chemotherapy. The results confirmed the single-agent activity of abemaciclib in heavily pretreated hormone receptor-positive, human epidermal growth factor receptor 2-negative MBC. Background: Abemaciclib is a selective cyclin-dependent kinase 4 and 6 inhibitor administered continuously for hormone receptor-positive (HR*), human epidermal growth factor receptor 2-negative (HER2(-)) advanced breast cancer. Abemaciclib is associated with dose-dependent early-onset diarrhea. nextMONARCH evaluated abemaciclib monotherapy (with or without prophylactic loperamide) and combined with tamoxifen for endocrine refractory metastatic breast cancer (MBC) after chemotherapy. Patients and Methods: nextMONARCH is an open-label, controlled, randomized, phase II study of women with endocrine-refractory HR+, HER2(-) MBC previously treated with chemoherapy. Patients received abemaciclib 150 mg plus tamoxifen 20 mg (A+T), abemaciclib 150 mg every 12 hours (A-150), or abemaciclib 200 mg plus prophylactic loperamide (A-200). The primary objective was progression-free survival (PFS). PFS analyses tested superiority of A+T to A-200 and informal noninferiority of A-150 to A-200. The secondary objectives included the objective response rate (ORR), safety, and pharmacokinetics. Results: The median PFS was 9.1 months for A+T versus 7.4 months for A-200 (hazard ratio, 0.815; 95% confidence interval, 0.556-1.193; P = .293). The A-200 PFS was comparable to that with A-150 at 6.5 months (hazard ratio, 1.045; 95% confidence nterval, 0.711-1.535; P = .811). The ORR was 34.6%, 24.1%, and 32.5% for A+T, A-150, and A-200, respectively. No new safety signals were identified. The incidence and severity of diarrhea (62.3%; grade 3, 7.8%) with A-200 was similar to that with A-150 (67.1%; grade 3, 3.8%). The pharmacokinetics were comparable to previous observations. Conclusions: The addition of tamoxifen to abemaciclib did not significantly improve PFS or ORR compared with abemaciclib monotherapy but confirmed the single-agent activity of abemaciclib in heavily pretreated HR+, HER2(-) MBC. Dose reductions and antidiarrheal medication generally managed diarrhea while maintaining efficacy. (C) 2020 Published by Elsevier Inc.