ANA CAROLINA PRADO RIBEIRO E SILVA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
5 resultados
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- Clinical outcomes of dental implants in head and neck cancer patients: An overview(2023) MARQUES, Nelson Pereira; PEREZ-DE-OLIVEIRA, Maria Eduarda; NORMANDO, Ana Gabriela Costa; MARQUES, Nadia Carolina Teixeira; EPSTEIN, Joel B.; MIGLIORATI, Cesar A.; MARTELLI JUNIOR, Hercilio; RIBEIRO, Ana Carolina Prado; ROCHA, Andre Caroli; BRANDAO, Thais Bianca; SANCHEZ, Francisco German Villanueva; GUEIROS, Luiz Alcino Monteiro; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan RogerObjective. The aim of this study was to evaluate the clinical outcomes of dental implants (DIs) in patients with head and neck can-cer (HNC) treated with radiotherapy (RT), isolated chemotherapy, or bone modifying agents (BMAs). Study Design. This study was registered in the Prospective Register of Systematic Reviews (CRD42018102772); conducted via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist; and based on PubMed, Scopus, Embase, Cochrane Library, Web of Science, and gray literature searches. The selection of studies was performed in 2 phases by 2 independent reviewers. The risk of bias (RoB) was assessed by the Measurement Tool to Assess the Methodological Quality of Systematic Reviews 2. Results. Twenty systematic reviews were included in the qualitative analysis. The majority scored as having high RoB (n = 11). Pri-mary DIs placement in the mandible of patients with HNC subjected to RT doses <50 Gy was associated with better survival rates. Conclusions. The placements of DIs could be considered safe in patients with HNC in sites of alveolar bone that received RT (<5000 Gy); however, no conclusions could be made in patients with cancer managed by chemotherapy or BMAs. Due to the heterogeneity of studies included, the recommendation for DIs placement in patients with cancer should be carefully considered. Future better controlled randomized clinical trials are required to provide enhanced clinical guidelines for best patient care. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;136:42-53)
- Extranodal NK/T cell lymphoma, nasal type: An updated overview(2021) SANCHEZ-ROMERO, Celeste; BOLOGNA-MOLINA, Ronell; ALMEIDA, Oslei Paes de; SANTOS-SILVA, Alan Roger; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; CARLOS, RomanExtranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is an aggressive malignancy associated with Epstein Barr virus infection, with a geographic and racial predilection for some Asian and Latin American countries. ENKTCL-NT manifests as a necrotic process affecting nasal or upper aerodigestive structures and, rarely, extranasal sites such as skin, and the gastrointestinal tract. ENKTCL-NT was characterized by its poor prognosis irrespective of clinical stage and therapy. However, during the last two decades, advances in its clinicopathologic, genetic and molecular characterization have been achieved, as have changes in the chemotherapy regimens that, in combination with radiotherapy, are significantly improving the survival of these patients, especially in initial stages. For these reasons, we present an overview of the historical background of ENKTCL-NT along with an updated review of its potential etiological factors, clinicopathologic and molecular features, as well as its prognostic models, current treatment protocols, and future directions on potential promising therapeutic approaches.
- Plasmacytoma and plasma cell myeloma affecting the jaws: A multi-institutional collaborative study(2021) SOUZA, Lucas Lacerda de; CACERES, Cinthia Veronica Bardalez Lopez de; VARGAS, Pablo Agustin; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan Roger; SILVA, Wagner Gomes da; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; PEREIRA, Juliana; MESQUITA, Ricardo Alves; PONTES, Flavia Sirotheau Correa; GONZALEZ-ARRIAGADA, Wilfredo Alejandro; PEDRAZA, Ricardo Martinez; ANDRADE, Bruno Augusto Benevenuto de; ROMANACH, Mario Jose; SOARES, Ciro Dantas; CARVALHO, Maria Goretti Freire de; PIRES, Fabio Ramoa; CARLOS, Roman; FONSECA, Felipe Paiva; PONTES, Helder Antonio Rebelo; ALMEIDA, Oslei Paes deBackground Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma). Methods Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports. Results Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%. Conclusion Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.
- Global frequency and distribution of head and neck cancer in pediatrics, a systematic review(2020) ARBOLEDA, Lady Paola Aristizabal; MENDONCA, Regina Maria Holanda de; LOPEZ, Eliana Elisa Munoz; ARAUJO, Anna Luiza Damaceno; PALMIER, Natalia Rangel; PAGLIONI, Mariana de Pauli; FONSECA, Jessica Montenegro; HOFFMANN, Iva Loureiro; CARDINALLI, Izilda Aparecida; CHAVES, Aline L. F.; ARANDA, Saray; BRANDAO, Thais Bianca; LOPES, Marcio Ajudarte; RIBEIRO, Ana Carolina Prado; TROCONIS, Cristhian Camilo Madrid; SANTOS-SILVA, Alan RogerBackground: Incidence and mortality rates of childhood cancer represent a global public health issue, however, the worldwide prevalence of head and neck cancer in pediatric patients (HNCPP) is still unknown. Therefore, this study aimed to describe the frequency and distribution of HNCPP worldwide. Methods: A specific search strategy was performed using MEDLINE, Scopus, and EMBASE to include studies based on hospital records, national cancer registries, and pathology files. Studies quality was assessed using the risk of bias checklist of the Joanna Briggs Institute Critical Appraisal. Results: Nineteen publications (15,970 cases) were included. Global frequency ranged from 0.25 % to 15 %. Male patients older than 10 years of age were most affected by lymphomas, followed by carcinomas and sarcomas. Non-Hodgkin lymphoma, Hodgkin lymphoma, rhabdomyosarcoma, thyroid carcinoma, and nasopharyngeal carcinoma were the main histopathological subtypes. Neck/lymph nodes were anatomical hotspots. Conclusions: This HNCPP global overview may guide secondary prevention strategies and future etiological studies.
- Clinical outcomes of dental implants in head and neck cancer patients: An overview (vol 136, pg 42, 2023)(2023) MARQUES, Nelson Pereira; PEREZ-DE-OLIVEIRA, Maria Eduarda; NORMANDO, Ana Gabriela Costa; MARQUES, Nadia Carolina Teixeira; EPSTEIN, Joel B.; MIGLIORATI, Cesar A.; MARTELLI-JUNIOR, Hercilio; RIBEIRO, Ana Carolina Prado; ROCHA, Andre Caroli; BRANDAO, Thais Bianca; SANCHEZ, Francisco German Vilanueva; GUEIROS, Luiz Alcino Monteiro; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan Roger