ANA CAROLINA PRADO RIBEIRO E SILVA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
14 resultados
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Agora exibindo 1 - 10 de 14
- Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review(2020) VASCONCELLOS, Adriele Ferreira Gouvea; PALMIER, Natalia Rangel; RIBEIRO, Ana Carolina Prado; NORMANDO, Ana Gabriela Costa; MORAIS-FARIA, Karina; GOMES-SILVA, Wagner; VECHIATO FILHO, Aljomar Jose; GOES, Mario Fernando de; LEME, Adriana Franco Paes; BRANDAO, Thais Bianca; LOPES, Marcio Ajudarte; MARSH, Philip D.; SANTOS-SILVA, Alan RogerRadiation-related caries (RRC) is a disease with a high potential for destruction of the dentition, which impairs quality of life in head-and-neck (HN) cancer (HNC) patients who undergo radiotherapy. In light of the recently described ""clustering of oral symptoms theory,"" the present systematic review (PROSPERO CRD42019132709) aims to assess HN and gastrointestinal (GI) symptom clusters among HNC patients and discusses how these indirect effects of cancer therapy play a pivotal role in the pathophysiology of RRC. The search was performed at PubMed, Scopus, and Embase and resulted in 11 studies that met the inclusion criteria. Data extraction was performed with respect to the presence of HN/GI symptom clusters among HNC patients. The methodological data of the studies included were assessed using the MAStARI and GRADE instruments. The most prevalent reported HN symptoms were dysphagia, xerostomia, and pain. Taste alterations and fatigue were also commonly reported by the patients. Loss of appetite and weight loss were regularly reported in the studies, as well as nausea and vomiting. The results of the present study suggest that HNC treatment generates clusters of oral symptoms, leading to dietary changes, impaired oral hygiene, enamel fragility, and a highly cariogenic oral environment, which may impact the risk for RRC. A better understanding of oral symptom clustering could be of considerable clinical significance for the oral health and quality of life of HNC patients. Therefore, contemporary protocols of RRC prevention must take this broader treatment scenario of symptom clusters such as oral side effects into account.
- The impact of head and neck radiotherapy on the dentine- enamel junction: a systematic review(2020) FONSECA, Jessica Montenegro; TROCONIS, Cristhian Camilo Madrid; PALMIER, Natalia Rangel; GOMES-SILVA, Wagner; PAGLIONI, Mariana de Pauli; ARAUJO, Anna Luiza Damaceno; ARBO-LEDA, Lady Paola Aristizabal; VECHIATO FILHO, Aljomar Jose; GONZALEZ-ARRIAGADA, Wilfredo Alejandro; GOES, Mario Fernando de; LOPES, Marcio Ajudarte; BRANDAO, Thais Bianca; VARGAS, Pablo Agustin; RIBEIRO, Ana Carolina Prado; SANTOS-SILVA, Alan RogerBackground: Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a pivotal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. Material and Methods: Systematic searches were conducted on three databases: Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory studies evaluating the effects of simulated or in vivo HNRT on the DEJ were included. The GRADE tool adapted for in vitro studies was used to assess the methodological quality. Results: Of the 154 initially selected studies, eight met the inclusion criteria, from which five studies were graded as high quality of evidence, two studies were graded as moderate quality and one as low quality. Two studies did not demonstrate DEJ alterations following HNRT while the other six articles described several organic and inorganic changes in the DEJ of irradiated teeth samples. These radiogenic events were mostly detected through micro and nanoindentation, Raman micro-spectroscopy, confocal microscopy, Western blotting and optical coherence tomography. Conclusions: HNRT may have a negative impact on the physical and chemical aspects of the DEJ, predisposing cancer patients to RRC and enamel delamination.
- Morphological patterns of circumpulpal dentin affected by radiation-related caries(2020) FAUSTINO, I.-S.-P.; PALMIER, N.-R.; FERNANDES, P.-M.; RIBEIRO, A.-C.-P.; BRANDãO, T.-B.; SANTOS-SILVA, A.-R.; VARGAS, P.-A.; LOPES, M.-A.Background: The aim of this work was to evaluate the microscopic characteristics through polarized light microscopy, scanning electron microscopy and the mineral content of circumpulpal dentin of irradiated (IT) and non-irradiated teeth (NIT), with deep caries that reached the root canal. Material and Methods: A total of 25 IT were analyzed macroscopically, and radiographed. 5 NIT were used as controls. Two 100-μm-thick sections, per specimen, were evaluated in a polarized light microscopy and a scanning electron microscope. Demographics and clinical data were collected. Results: The results did not demonstrate distinct morphology of the IT compared with NIT. Mineral content values by weight percentage of Ca and P were also similar, corresponding to 66.65% and 33.21% in the IT and 66.60% and 33.29% in the NIT. The Ca/P ratio did not show statistical differences between groups being respectively 2.74 and 2.72, in the IT and NIT (p> 0.05). Conclusions: Radiotherapy does not change morphology and mineral content of circumpulpal dentin in IT. © Medicina Oral S. L.
- Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis(2020) MARIZ, Bruno Augusto Linhares Almeida; KOWALSKI, Luiz Paulo; JR, William Nassib William; CASTRO, Gilberto de; CHAVES, Aline Lauda Freitas; SANTOS, Marcos; OLIVEIRA, Thiago Bueno de; ARAUJO, Anna Luiza Damaceno; NORMANDO, Ana Gabriela Costa; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; VARGAS, Pablo Agustin; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan RogerObjectives: to provide accurate information about the global prevalence of human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (OPSCC). Material and methods: a systematic review was performed using three main electronic databases. Studies were independently assessed by two reviewers based on established eligibility criteria, to identify the prevalence of HPV-driven OPSCC following criteria defined by the American Society of Clinical Oncology. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Statistical software MedCalc was used to perform meta-analyses. Results: from 2215 records found, 15 were included, reporting data from 6009 patients (time period range: 1980-2016), distributed in 11 countries. Eleven studies were considered as presenting low risk, and four as moderate risk of bias. Using proportion meta-analysis, pooled prevalence of HPV-driven OPSCC was 44.8 % (95 %CI: 36.4-53.5 %; i(2) = 97.6 %), with the highest rates in New Zealand (74.5 %; 95 %CI: 60.9-85.3 %), and the lowest in Brazil (11.1 %; 95 %CI: 4.5-21.5 %). HPV prevalence was similar between males (45.7 %; 95 %CI: 36.5-55.0 %; i(2) = 96.4 %) and females (42.2 %; 95 %CI: 34.3- 50.5 %; i(2) = 85.4 %). Mean/median age ranged from 59.1-67.1 years in the HPV-negative group, and from 55.7-63.5 years in the HPV-positive group. There was an overall discordance between testing by p16 (49.4 %; 95 %CI, 38.2-60.5 %; i(2) = 96.2 %) and p16+ISH/PCR (44.7 %; 95 %CI, 33.5-56.2 %; i(2) = 96.4 %). Conclusion: Overall pooled prevalence of HPV-driven OPSCC was approximately 45 %, with similar distribution among males and females. Double p16/HPV-DNA/RNA testing may be considered to increase specificity and prognostic accuracy.
- New Insights for the Pathogenesis of COVID-19-Related Dysgeusia(2020) MARIZ, B. A. L. A.; BRANDAO, T. B.; RIBEIRO, A. C. P.; LOPES, M. A.; SANTOS-SILVA, A. R.
- Strategies for communicating oral and oropharyngeal cancer diagnosis: why talk about it?(2020) ALVES, Carolina Guimaraes Bonfim; TREISTER, Nathaniel Simon; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; TONAKI, Juliana Ono; LOPES, Marcio Ajudarte; RIVERA, Cesar; SANTOS-SILVA, Alan RogerObjective. This review aimed to explore the paradigms of disclosing a cancer diagnosis with a focus on oral and oropharyngeal cancer and patient-related considerations. Study Design. A search of MEDLINE, Embase, and Scopus was conducted using the following keywords: oral cancer; mouth lesions; oncology; breaking bad news; truth disclosure; and communication skills training. English and Spanish language studies published through October 2019 were included. Results. The way bad news is conveyed to patients with cancer may affect their comprehension of information, emotional distress, treatment adherence, and health outcomes. Models of communication that are focused on patients' preferences may result in better treatment outcomes. Available protocols, such as SPIKES and ABCDE, have useful recommendations for health care professionals communicating an oral cancer diagnosis. However, it is important to be attentive to the particular information needs of patients. Conclusions. When communicating a cancer diagnosis, providers should employ validated methods of information delivery and support for oncology patients. Further studies are needed to evaluate the experiences and preferences of patients with oral cancer during these communications.
- Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy(2020) FARIA, Karina Morais; GOMES-SILVA, Wagner; KAUARK-FONTES, Elisa; BONFIM-ALVES, Carolina Guimaraes; KOWALSKI, Luiz Paulo; PRADO-RIBEIRO, Ana Carolina; VECHIATO-FILHO, Aljomar Jose; LOPES, Marcio Ajudarte; MARTA, Gustavo Nader; JR, Gilberto de Castro; LEME, Adriana Franco Paes; MIGLIORATI, Cesar Augusto; SANTOS-SILVA, Alan Roger; BRANDAO, Thais BiancaThis communication discusses the current challenges of oral mucositis (OM) management during the pandemic COVID-19 outbreak and reflects about an extraoral photobiomodulation protocol as an optimal alternative for preventing and treating OM in advanced cancer patients while minimizing the risk of infection by avoiding intraoral manipulation.
- Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients(2020) FERNANDES, Diego Tetzner; HEERDEN, Willie F. P. van; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; MELLO, Evandro Sobroza de; RIVERA, Cesar; HEERDEN, Marlene B. van; GONDAK, Rogerio; SANTOS-SILVA, Alan Roger; VARGAS, Pablo Agustin; LOPES, Marcio AjudarteBackground: Although new digital pathology tools have improved the positive cell quantification, there is a heterogeneity of the quantification methods in the literature. The aim of this study was to evaluate and propose a novel dendritic cells quantification method in squamous cell carcinoma comparing it with a conventional quantification method. Material and Methods: Twenty-six squamous cell carcinomas HIV-positive cases affecting the oropharynx, lips and oral cavity were selected. Immunohistochemistry for CD1a, CD83, and CD207 was performed. The immunohistochemical stains were evaluated by automated examination using a positive pixel count algorithm. A conventional quantification method (unspecific area method; UA) and a novel method (specific area method; SA) were performed obtaining the corresponding density of positive dendritic cells for the intratumoral and peritumoral regions. The Mann-Whitney U test was used to verify the influence of the quantification methods on the positive cell counting according to the evaluated regions. Data were subjected to the ANOVA and Student's t-test to verify the influence of the tumour location, stage, histological grade, and amount of inflammation on the dendritic cells density counting. Results: The cell quantification method affected the dendritic cells counting independently of the evaluated region (P-value < 0.05). Significant differences between methods were also observed according to the tumour features evaluations. Conclusions: The positive cell quantification method influences the dendritic cells density results. Unlike the conventional method (UA method), the novel SA method avoids non-target areas included in the hotspots improving the reliability and reproducibility of the density cell quantification.
- Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis(2020) PAGLIONI, Mariana de Pauli; MIGLIORATI, Cesar Augusto; FAUSTINO, Isabel Schausltz Pereira; MARIZ, Bruno Augusto Linhares Almeida; ROZA, Ana Luiza Oliveira Correa; VARGAS, Pablo Agustin; LEME, Adriana Franco Paes; BRANDAO, Thais Bianca; RIBEIRO, Ana Carolina Prado; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan RogerOral leukoplakia (OL) is a white lesion with high potential of recurrence and malignant transformation. The variable clinical and histopathological features of OL may potentially impact both treatment and prognosis. Current literature shows that post treatment rates of recurrence and malignant transformation vary widely. The use of surgical lasers have been proposed with the objective of improving outcomes. We performed a systematic review and a comprehensive meta-analysis dedicated to pooling the rates of recurrence and malignant transformation of OL lesions treated using the main types of surgical lasers available. Scopus, MEDLINE/PubMed, and Embase were searched electronically. A total of 36 articles ma the inclusion criteria. Selected studies included OL lesions that were treated by evaporation or excision using Nd:YAG laser, Er:YAG laser, CO2 laser, KTP laser, or diode laser. The results of this systematic review and meta-analysis suggest that surgical laser excision of OL may decrease recurrence rates but have no effect on the malignant transformation of OL when compared with conventional treatments.
- The impact of radiation caries in the quality of life of head and neck cancer patients(2020) PAGLIONI, Mariana de Pauli; PALMIER, Natalia Rangel; PRADO-RIBEIRO, Ana Carolina; FREGNANI, Eduardo Rodrigues; GAVIAO, Maria Beatriz Duarte; BRANDAO, Thais Bianca; LOPES, Marcio Ajudarte; RIBEIRO, Ana Paula Dias; MIGLIORATI, Cesar Augusto; SANTOS-SILVA, Alan RogerPurpose The objective of this multicentre study was to verify the relationship between the scores of quality of life (QoL) and the decayed, missing and filled teeth (DMFT) and radiation caries (RC) in patients treated with radiation therapy (RT) for head and neck cancer, and through this to determine if RC is capable of causing a significant decrease in the QoL. Methods One hundred patients were divided into 2 groups: patients with at least 1 year of RT completion who developed RC (study group, n = 50); and patients with at least 1 year of RT completion who did not develop RC (control group, n = 50). All patients answered the Brazilian-Portuguese version of the University of Washington quality of life (UW-QoL) questionnaire, which was divided into physical and social-emotional functioning domains and evaluated the DMFT index score. Results The mean score of QoL was 927.2 in the control group and 878.1 in the study group (P = 0.24). The mean score of DMFT was 30.5 in the study group and 20.7 in the control group (P = 0.001). The items recreation and saliva, which belong to the physical function domain, showed a statistically significant difference between the study and control groups (P = 0.031 and P = 0.047, respectively). Saliva was the item with the higher number of patient complaints in both groups. Conclusion RC had a negative impact on the QoL of HNC patients.