ANA CAROLINA PRADO RIBEIRO E SILVA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
11 resultados
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- Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases(2022) ARAUJO, Gabriela Ribeiro de; COSTA, Sara Ferreira dos Santos; MESQUITA, Ricardo Alves; GOMEZ, Ricardo Santiago; SANTOS, Jean Nunes dos; PONTES, Helder Antonio Rebelo; ANDRADE, Bruno Augusto Benevenuto de; ROMANACH, Mario Jose; AGOSTINI, Michelle; VARGAS, Pablo Agustin; CACERES, Cinthia Veronica Bardalez Lopez de; SANTOS-SILVA, Alan Roger; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; TOMASI, Ramiro Alejandro; FERREYRA, Ruth Salome; ALMEIDA, Oslei Paes de; FONSECA, Felipe PaivaSmooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients' pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for alpha-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis.
- The need for communication between clinicians and pathologists in the context of oral and maxillofacial diseases(2022) PEREZ-DE-OLIVEIRA, Maria Eduarda; HEERDEN, Willie van; MOTTA, Ana Carolina Fragoso; RODRIGUES-FERNANDES, Carla Isabelly; ROMANACH, Mario Jose; AGOSTINI, Michelle; GUEIROS, Luiz Alcino Monteiro; VARGAS, Pablo Agustin; LOPES, Marcio Ajudarte; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; ALMEIDA, Oslei Paes de; KHURRAM, Syed Ali; SANTOS-SILVA, Alan RogerGood communication between clinicians and pathologists is a vital element in the diagnostic process, and poor communication can adversely affect patient care. There is a lack of research about communication in diagnostic oral and maxillofacial pathology. This narrative review explores different aspects of the quality of communication between clinicians and oral pathologists, with a focus on the diagnosis of oral and maxillofacial diseases. An electronic search was carried out in MEDLINE through the PubMed, Scopus, and Embase databases up to April 2021. No studies reporting communication, its adequacy or the required skills between clinicians and pathologists in oral diagnosis were found. According to studies published in medicine, strategies for improving communication skills include clinician-pathologist collaboration; a well-formatted, clear and thorough report; training in communication skills; and patient-centered care. Further studies evaluating the current practices and quality in oral and maxillofacial pathology are required to identify barriers and encourage optimal communication to facilitate diagnosis, as well as patient safety.
- Oral medicine (stomatology) in Brazil: the first 50 years and counting(2022) SANTOS-SILVA, Alan Roger; LOPES, Marcio Ajudarte; PEDROSO, Caique Mariano; RIBEIRO, Ana Carolina Prado; FONSECA, Felipe Paiva; BRANDAO, Thais Bianca; GUEIROS, Luiz Alcino Monteiro; ROCHA, Andre Caroli; PIRES, Fabio Ramoa; MIRANDA, Aguida Aguiar; MARTELLI JUNIOR, Hercilio; ALVES, Fabio de Abreu; MARCUCCI, Marcelo; LEMOS, Celso Augusto; SUGAYA, Norberto Nobuo; MARCUCCI, Gilberto; CARRARD, Vinicius Coelho; MARTINS, Manoela Domingues; CARDOSO, Abel Silveira; MIGLIORATI, Cesar AugustoThis review outlines the historical perspective, status, and future challenges of oral medicine (stomatology) in Brazil based on the records of the Brazilian Society of Stomatology and Oral Pathology (SOBEP) and the Brazilian Federal Dental Council as well as expert evidence input from academic leaders from 3 different generations of Brazilian oral medicine specialists. The beginning of oral medicine in Brazil dates to 1969, followed by the organization of SOBEP in 1974; however, official recognition as an independent specialty was achieved more recently within the Brazilian Federal Dental Council in 1992. After a 50-year maturation period of oral medicine in Brazil in terms of specialty crystallization across dentistry, medicine, and research, it is now time to follow the historical trends of the specialty internationally and establish a standard curriculum at a post-graduate level that will lead to uniformity of training for oral medicine in Brazil. (Oral Surg Oral Med Oral Pathol Oral Radiol 2022;134:57-64)
- COVID-19 impact on anxiety and depression in head and neck cancer patients: A cross-sectional study(2022) RODRIGUES-OLIVEIRA, Leticia; KAUARK-FONTES, Elisa; ALVES, Carolina Guimaraes Bonfim; TONAKI, Juliana Ono; GUEIROS, Luiz Alcino; MOUTINHO, Karina; MARTA, Gustavo Nader; BARROS, Luciana Rodrigues Carvalho; SANTOS-SILVA, Alan Roger; BRANDAO, Thais Bianca; PRADO-RIBEIRO, Ana CarolinaObjective: To evaluate whether the coronavirus disease 2019 has increased anxiety, depression, and distress levels in head and neck cancer (HNC) patients undergoing radiotherapy (RT). Methods: In this cross-sectional study, RT-HNC patients were surveyed using the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression and the distress thermometer (DT) for distress. HADS scores were compared with data pre-COVID-19. Additionally, we evaluated the COVID-19 impact on daily routines, treatment, and cancer care through a questionnaire. Results: Fifty patients were included. The HADS mean score and estimated rates were 4.34 (+/- 4.06)/22% for anxiety and 5.08 (+/- 4.82)/22% for depression; in comparison, our historical control had 4.04 (+/- 3.59)/20% for anxiety (p = .79) and 4.03 (+/- 3.62)/17% for depression (p = .49). Mean DT score was 3.68 (+/- 2.77). Responders were aware of COVID-19, afraid of having medical complications, believed it was life-threatening, did not miss appointments, believed their treatment was not impacted, and felt safe at the hospital amid the pandemic. Conclusion: This study suggests that anxiety, depression, and distress levels found in RT-HNC patients did not increase during the pandemic. Patients were afraid of being infected by COVID-19; however, they complied with their cancer treatment.
- To extract or not extract teeth prior to head and neck radiotherapy? A systematic review and meta-analysis(2022) NORMANDO, Ana Gabriela Costa; PEREZ-DE-OLIVEIRA, Maria Eduarda; GUERRA, Eliete Neves Silva; LOPES, Marcio Ajudarte; ROCHA, Andre Caroli; BRANDAO, Thais Bianca; PRADO-RIBEIRO, Ana Carolina; GUEIROS, Luiz Alcino Monteiro; EPSTEIN, Joel B.; MIGLIORATI, Cesar Augusto; SANTOS-SILVA, Alan RogerPurpose Teeth with poor prognosis are generally recommended to be extracted prior to head and neck radiotherapy (RT) to reduce the risk of developing osteoradionecrosis (ORN), although controversies have been reported. The present systematic review aimed to determine whether tooth extraction prior to head and neck RT may be associated with a reduced risk of developing ORN compared to dental extraction during or after RT. Methods The review protocol was registered in PROSPERO (CRD42021241631). The review was reported according to the PRISMA checklist and involved a comprehensive search of PubMed, Scopus, Embase, Cochrane Library, LILACS, and Web of Science, in addition to the gray literature. The selection of studies was performed in two phases by two reviewers independently. The risk of bias of individual studies was analyzed using the Joanna Briggs Institute checklist for cross-sectional studies, and the certainty of evidence was assessed using the GRADE tool. Results Twenty-eight observational studies were included in the qualitative synthesis, which showed substantial heterogeneity regarding the association between the timing of tooth extraction and ORN development. Twenty-seven of 28 studies were pooled in a meta-analysis that demonstrated a significant association between an increased risk of ORN and post-RT tooth extraction (odds ratio: 1.98; 95% CI: 1.17-3.35; p = 0.01). Conclusion It was confirmed with moderate certainty that dental extractions should be performed prior to the start of head and neck RT to reduce the risk of ORN.
- Are intraoral stents effective in reducing oral toxicities caused by radiotherapy? A systematic review and meta-analysis(2022) BRANDAO, Thais Bianca; PINTO, Henrique da Graca; VECHIATO FILHO, Aljomar Jose; FARIA, Karina Morais; OLIVEIRA, Maria Cecilia Querido de; PRADO-RIBEIRO, Ana Carolina; DIAS, Reinaldo Brito; SANTOS-SILVA, Alan Roger; BATISTA, Victor Eduardo de SouzaStatement of problem. Intraoral stents have been provided to minimize acute and chronic toxicities induced by radiotherapy, including oral mucositis, salivary changes, trismus, radiation-related caries, and osteoradionecrosis. However, a systematic review and meta-analysis is necessary to determine their effectiveness. Purpose. The purpose of this systematic review and meta-analysis was to determine the effectiveness of intraoral stent use and determine whether these prosthetic devices can reduce radiation dosage to nontargeted oral tissues and adverse effects related to head and neck radiation. Material and methods. Two independent reviewers made a systematic search for articles published from January 2010 to March 2020 in 3 databases, supplemented by a manual search. Studies were included if they were clinical trials (randomized controlled trials, both prospective and retrospective), published in English, and evaluated radiation dose and oral adverse side effects (acute or chronic) induced by radiotherapy of participants with and without intraoral stents. Results. The search strategy identified 201 studies; of which, 9 were included. A total of 251 participants were evaluated; of whom, 168 (77.3%) used intraoral stents and 57 (22.7%) were treated with radiotherapy without a prosthetic device. A statistically significant difference was found regarding the use of intraoral stents for preventing oral mucositis (P<.001), salivary changes (P=.003), and trismus (P<.02). A funnel plot showed asymmetry among the differences of means in all selected studies. Conclusions. Intraoral stents have a positive effect on preventing oral mucositis. Further clinical trials are needed to address the flaws identified in the present systematic review.
- HIV-related non-Hodgkin lymphomas affecting the oral cavity: a clinicopathologic study of 11 cases(2022) UCHOA, Daniel Cavallero Colares; PONTES, Flavia Sirotheau Correa; SOUZA, Lucas Lacerda de; SANTOS, Gabriela Sepeda dos; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; OLIVEIRA, Leticia Rodrigues de; GOMES, Carolina Cavalieri; SANTOS-SILVA, Alan Roger; FONSECA, Felipe Paiva; ALMEIDA, Oslei Paes de; PONTES, Helder Antonio RebeloBackground: HIV-related non-Hodgkin lymphomas of the oral cavity are rare lesions with aggressive clinical behaviour. The aim of this study is to describe the clinicopathological features of a series of HIV-related oral non Hodgkin lymphomas. Material and Methods: Eleven cases of oral lymphomas affecting HIV-positive patients were retrieved from 2012 to 2019. Clinicopathological features regarding age, sex, tumour location, clinical presentation, laboratory findings, disease stage and follow-up were obtained. Histologic, immunohistochemical and in situ hybridization for EBV detection were done for diagnosis confirmation. Overall survival was estimated by Kaplan-Meier curve. Results: Males predominated, with a mean age of 40.3 years-old. Maxilla and mandible were the mostly affected. Plasmablastic lymphoma and diffuse large B-cell lymphoma not otherwise specified (NOS) were the main histological types. Lesions presented as reddish ulcerated swellings, representing the first sign of AIDS in six cases. Stage IV were common (7 cases) and the mean HIV viral load was 10,557 copies/mL, with a mean of 266 CD4+ cells/mm3, 1,278 CD8+ cells/mm3 and a CD4+/CD8+ ratio of 0.26. Eight patients died of the disease (72.7%). Overall survival revealed that 78.2% of the patients died after 21 months of follow-up. Conclusions: HIV-related oral lymphomas present a poor prognosis usually diagnosed in advanced stages and in our series plasmablastic lymphoma was the most common subtype.
- Over 300 Radiation Caries Papers: Reflections From the Rearview Mirror(2022) PEDROSO, Caique Mariano; MIGLIORATI, Cesar Augusto; EPSTEIN, Joel B.; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; LOPES, Marcio Ajudarte; GOES, Mario Fernando de; SANTOS-SILVA, Alan RogerRadiation caries (RC) is an aggressive oral toxicity in head and neck cancer survivors, which develops 6 to 12 months after head and neck radiotherapy. It initially affects the tooth cervical/incisal surfaces, and if not promptly diagnosed/managed, progresses to dental crown amputation and risk of osteoradionecrosis. It results from a multidimensional cluster of treatment-induced oral symptoms, including hyposalivation, dietary changes, and oral hygiene impairment. Although recognized as a frequent complication of radiotherapy and extensively assessed by a myriad of retrospective, in vitro, and in situ studies, RC patients are still orphans of clinically validated methods for risk prediction, prevention, and treatment of early lesions. This review provides a historical overview of science-based concepts regarding RC pathogenesis and treatment, emphasizing the growing demand for interventional clinical studies (randomized trials).
- Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer(2022) BUSSO-LOPES, Ariane F.; NEVES, Leandro X.; CAMARA, Guilherme A.; GRANATO, Daniela C.; PRETTI, Marco Antonio M.; HEBERLE, Henry; PATRONI, Fabio M. S.; SA, Jamile; YOKOO, Sami; RIVERA, Cesar; DOMINGUES, Romenia R.; NORMANDO, Ana Gabriela C.; ROSSI, Tatiane De; MELLO, Barbara P.; GALDINO, Nayane A. L.; PAULETTI, Bianca A.; LACERDA, Pammela A.; RODRIGUES, Andre Afonso N.; CASARIM, Andre Luis M.; LIMA-SOUZA, Reydson A. De; DAMAS, Ingrid I.; V, Fernanda Mariano; GOLLOB, Kenneth J.; MEDINA, Tiago S.; CERVIGNE, Nilva K.; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; VILLA, Luisa L.; UNO, Miyuki; BORONI, Mariana; KOWALSKI, Luiz Paulo; GONZALEZ-ARRIAGADA, Wilfredo Alejandro; LEME, Adriana F. PaesThe poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the biology and potential metastasis biomarkers that may assist in clinical decision-making. Protein profiles are strictly associated with immune modulation across datasets, and this provides the basis for investigating immune markers associated with metastasis. The proteome of LN metastatic cells recapitulates the proteome of the primary tumor sites. Conversely, the LN microenvironment proteome highlights the candidate prognostic markers. By integrating prioritized peptide, protein, and transcript levels with machine learning models, we identify nodal metastasis signatures in blood and saliva. We present a proteomic characterization wiring multiple sites in HNC, thus providing a promising basis for understanding tumoral biology and identifying metastasis-associated signatures. The biological understanding of poor prognosis associated with lymph node metastasis in head and neck cancer (HNC) remains crucial. Here, a proteomic characterisation of 140 multisite samples from a 59-HNC patient cohort and machine learning reveals potential biomarkers and metastasis related signatures.
- Piroxicam-induced fixed drug eruption in palatal mucosa(2022) TOMO, S.; SANTOS, I. da Silva; CUNHA, J. L. da Silva; MIYAHARA, G. I.; RIBEIRO, A. C. Prado; SILVA, A. R. dos Santos; SIMONATO, L. E.Background: Fixed drug eruption is a drug reaction characterized by the recurrent occurrence of erosive or ulcerative lesions in skin or mucosa surfaces upon the use of a specific drug. The occurrence of fixed drug eruption in oral mucosa is rare and ill documented. Case report: A 37-year-old woman who presented with recurrent erosive lesions in the palatal marginal gingiva of the upper first molars for 3 consecutive months. In anamnesis and follow-up, the time association with the intake of piroxicam to treat menstrual pain led us to the diagnosis of fixed drug eruption. Conclusion: Piroxicam is a rare culprit drug to fixed drug eruption, especially in oral mucosa. © 2021 The British Association of Oral Surgeons and John Wiley & Sons Ltd.