NIVALDO ALONSO

(Fonte: Lattes)
Índice h a partir de 2011
23
Lattes
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Unidades Organizacionais
Departamento de Cirurgia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/04 - Laboratório de Microcirurgia, Hospital das Clínicas, Faculdade de Medicina - Líder

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Autor: PASSOS-BUENO, Maria Rita × search.filters.applied.f.dateIssued: 2011 ×

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  • article 8 Citação(ões) na Scopus
    Histological and radiological changes in cranial bone in the presence of bone wax
    (2011) RAPOSO-AMARAL, Cassio Eduardo; ALMEIDA, Ana Beatriz Albino de; PASCHOAL, Gustavo; BUENO, Daniela Franco; VULCANO, Luiz Carlos; PASSOS-BUENO, Maria Rita; ALONSO, Nivaldo
    Purpose: To quantify the amount of bone formation in the calvarial region of Wistar rats after craniotomy using bone wax as a haemostatic agent. Methods: Surgery to produce bilateral, symmetric, full-thickness cranial defects (area: 18 mm(2)) was performed in eight animals. The right side of the cranium remained open and the edges of the left side osseous defect was covered with bone wax. Calvaria were imaged immediately after surgery and 12 weeks postoperatively by computerized tomography. The areas of the bone defects were measured in three-dimensional images using Magics 13.0 (Materialise-Belgic, software CAD). Results: The average amount of bone formation on the left and right side respectively was 4.85 mm(2) and 8.16 mm(2). Statistically significant differences between the amount of bone formation on the left and right sides were seen. Conclusion: Bone wax significantly diminishes the rate of bone formation in calvarial defects in a rat model.
  • article 24 Citação(ões) na Scopus
    Genetic Contribution for Non-Syndromic Cleft Lip With or Without Cleft Palate (NS CL/P) in Different Regions of Brazil and Implications for Association Studies
    (2011) BRITO, Luciano A.; CRUZ, Lucas A.; ROCHA, Katia M.; BARBARA, Ligia K.; SILVA, Camila B. F.; BUENO, Daniela F.; AGUENA, Meire; BERTOLA, Debora R.; FRANCO, Diogo; COSTA, Andre M.; ALONSO, Nivaldo; OTTO, Paulo A.; PASSOS-BUENO, Maria Rita
    Non-syndromic cleft lip with or without cleft palate (NS CL/P) is a complex disease in which heritability estimates vary widely depending on the population studied. To evaluate the importance of genetic contribution to NS CL/P in the Brazilian population, we conducted a study with 1,042 families from five different locations (Santarem, Fortaleza, Barbalha, Maceio, and Rio de Janeiro). We also evaluated the role of consanguinity and ethnic background. The proportion of familial cases varied significantly across locations, with the highest values found in Santarem (44%) and the lowest in Maceio (23%). Heritability estimates showed a higher genetic contribution to NS CL/P in Barbalha (85%), followed by Santarem (71%), Rio de Janeiro (70%), Fortaleza (64%), and Maceio (45%). Ancestry was not correlated with the occurrence of NS CL/P or with the variability in heritability. Only in Rio de Janeiro was the coefficient of inbreeding significantly larger in NS CL/P families than in the local population. Recurrence risk for the total sample was approximately 1.5-1.6%, varying according to the location studied (0.6-0.7% in Maceio to 2.2-2.8% in Barbalha). Our findings show that the degree of genetic contribution to NS CL/P varies according to the geographic region studied, and this difference cannot be attributed to consanguinity or ancestry. These findings suggest that Barbalha is a promising region for genetic studies. The data presented here will be useful in interpreting results from molecular analyses and show that care must be taken when pooling samples from different populations for association studies. (C) 2011 Wiley-Liss, Inc.