DEBORA RAQUEL BENEDITA TERRABUIO

(Fonte: Lattes)
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 7 de 7
  • article 3 Citação(ões) na Scopus
    COST EFFECTIVENESS OF USING TERLIPRESSIN TO TREAT HEPATORENAL SYNDROME
    (2022) FERREIRA, Luciana Marcondes; TERRABUIO, Débora Raquel; FERREIRA, Caroline Marcondes; MAZO, Daniel Ferraz de Campos; HADDAD, Luciana Bertocco de Paiva
    ABSTRACT Background Hepatorenal syndrome (HRS) is the most severe form of acute kidney injury in patients with advanced cirrhosis, and it is associated with high mortality. It is usually diagnosed according to criteria defined by the International Ascites Club. Currently, the most frequently indicated pharmacological therapy for the treatment of HRS is a combination of splanchnic vasoconstrictors (terlipressin or norepinephrine) in combination with albumin. With the progressive increase in healthcare spending, it is important to conduct a cost-effectiveness analysis of pharmacological treatment in patients who are diagnosed with HRS. Objective: To perform a cost-effectiveness assessment for the use of terlipressin in combination with albumin to treat HRS in patients with cirrhosis. Methods: Economic evaluation of cost-effectiveness based on secondary data from studies showed the efficacy of terlipressin therapy compared with norepinephrine combined with albumin or albumin alone. The cost-effectiveness analysis was calculated using an incremental cost-effectiveness ratio (ICER), and a sensitivity analysis was developed by varying the values of therapies and probabilities. The Brazilian real was the currency used in the analysis, and the results were converted to US dollars. Results: After selection, eligibility, and evaluation of the quality of publications, the results demonstrated that administration of terlipressin or norepinephrine in combination with albumin in patients diagnosed with HRS type 1 was efficacious. The cost of treatment with terlipressin in combination with albumin was USD $1,644.06, administration of albumin alone was USD $912.02, and norepinephrine plus albumin was USD $2,310.78. Considering that the combination therapies demonstrated effectiveness, the incremental cost of terlipressin and norepinephrine in combination with albumin was USD $666.73, and an effectiveness of 0.570 was found for terlipressin in combination with albumin and 0.200 for norepinephrine in combination with albumin. The incremental effectiveness was 0.370, and the ICER was USD $1,801.97. Thus, the parameters of increasing cost per therapy and ICER indicated that the combined therapy of terlipressin plus albumin was cost effective compared to albumin alone or norepinephrine plus albumin in a public single-payer healthcare system. Conclusion: A cost-effectiveness analysis showed that terlipressin in combination with albumin when administered concomitantly to patients who were diagnosed with type 1 HRS is cost-effective compared to norepinephrine in combination with albumin administered in a controlled environment.
  • article 9 Citação(ões) na Scopus
    Coronavirus Disease 2019 in the Early Postoperative Period of Liver Transplantation: Is the Outcome Really So Positive?
    (2021) WAISBERG, Daniel Reis; ABDALA, Edson; NACIF, Lucas Souto; DUCATTI, Liliana; HADDAD, Luciana Bertocco; MARTINO, Rodrigo Bronze; PINHEIRO, Rafael Soares; ARANTES, Rubens Macedo; GALVAO, Flavio Henrique; GOUVEIA, Larissa Nunes; TERRABUIO, Debora Raquel; DARCE, George Felipe; ROCHA-SANTOS, Vinicius; ANDRAUS, Wellington; CARNEIRO-D'ALBUQUERQUE, Luiz Augusto
  • article 1 Citação(ões) na Scopus
    Insights in the approach of long-term liver transplant recipients with COVID-19
    (2021) TERRABUIO, Debora Raquel Benedita; HADDAD, Luciana; DUCATTI, Liliana; GOUVEIA, Larissa Nunes; ROCHA-SANTOS, Vinicius; FERREIRA, Renee Mignolo Tanaka; DARCE, George Felipe; CARDOSO, Ana Julia Andrade; CARRILHO, Flair Jose; ANDRAUS, Wellington; ABDALA, Edson; D'ALBUQUERQUE, Luiz Augusto Carneiro
  • article 4 Citação(ões) na Scopus
    Technological Innovation in Outpatient Assistance for Chronic Liver Disease and Liver Transplant Patients During the Coronavirus Disease Outbreak: A Method to Minimize Transmission
    (2020) ONO, Suzane Kioko; ANDRAUS, Wellington; TERRABUIO, Debora Raquel Benedita; COBELLO-JUNIOR, Vilson; ARAI, Lilian; DUCATTI, Liliana; HADDAD, Luciana Bertocco de Paiva; D'ALBUQUERQUE, Luiz Augusto Carneiro; CARRILHO, Flair Jose
  • article 5 Citação(ões) na Scopus
    Hepatic Artery Thrombosis in Liver Transplantation in Adult Recipients Using Pediatric Deceased Donors
    (2020) FORTUNATO, Allana C.; PINHEIRO, Rafael S.; NACIF, Lucas S.; WAISBERG, Daniel R.; DUCATTI, Liliana; ROCHA-SANTOS, Vinicius; GALVAO, Flavio H. F.; HADDAD, Luciana B. P.; ABDALA, Edson; SONG, Alice T. W.; TERRABUIO, Debora R. B.; BEZERRA, Regis O. F.; MACEDO, Rubens A.; MARTINO, Rodrigo B.; ANDRAUS, Wellington; CARNEIRO-D'ALBUQUERQUE, Luiz A.
  • conferenceObject
    Liver transplant recipients infected with Sars-CoV-2 in the early versus late postoperative period: is there a difference in outcomes?
    (2021) LIMA, M. R. Damasceno; WAISBERG, D.; TERRABUIO, D. R. Benedita; SONG, A.; ABDALA, E.; DUCATTI, L.; HADDAD, L. Bertocco; GOUVEIA, L. Nunes; ROCHA-SANTOS, V.; MARTINO, R. Bronze; NACIF, L. Souto; PINHEIRO, R. Soares; ARANTES, R. Macedo; ERNANI, L.; GALVAO, F. H.; LEE, Dong Won A.; MALBOUISSON, L. M.; ROCHA FILHO, J. Avancini; ANDRAUS, W.; CARNEIRO-D'ALBUQUERQUE, L. A.
  • article 20 Citação(ões) na Scopus
    Liver transplant recipients infected with SARS-CoV-2 in the early postoperative period: Lessons from a single center in the epicenter of the pandemic
    (2021) WAISBERG, Daniel Reis; ABDALA, Edson; NACIF, Lucas Souto; HADDAD, Luciana Bertocco; DUCATTI, Liliana; SANTOS, Vinicius Rocha; GOUVEIA, Larissa Nunes; LAZARI, Carolina Santos; MARTINO, Rodrigo Bronze; PINHEIRO, Rafael Soares; ARANTES, Rubens Macedo; TERRABUIO, Debora Raquel; MALBOUISSON, Luiz Marcelo; GALVAO, Flavio Henrique; ANDRAUS, Wellington; CARNEIRO-D'ALBUQUERQUE, Luiz Augusto
    The impact of coronavirus disease-19 (COVID-19) in liver recipients remains largely unknown. Most data derive from small retrospective series of patients transplanted years ago. We aimed to report a single-center case series of five consecutive patients in the early postoperative period of deceased-donor liver transplantation who developed nosocomial COVID-19. Two patients presented important respiratory discomfort and eventually died. One was 69 years old and had severe coronary disease. She rapidly worsened after COVID-19 diagnosis on 9th postoperative day. The other was 67 years old with non-alcoholic steatohepatitis, who experienced prolonged postoperative course, complicated with cytomegalovirus infection and kidney failure. He was diagnosed on 36th postoperative day and remained on mechanical ventilation for 20 days, ultimately succumbing of secondary bacterial infection. The third, fourth, and fifth patients were diagnosed on 10th, 11th, and 18th postoperative day, respectively, and presented satisfactory clinical evolution. These last two patients were severely immunosuppressed, since one underwent steroid bolus for acute cellular rejection and another also used anti-thymocyte globulin for treating steroid-resistant rejection. Our novel experience highlights that COVID-19 may negatively impact the postoperative course, especially in elder and obese patients with comorbidities, and draws attention to COVID-19 nosocomial spread in the early postoperative period.