DEBORA RAQUEL BENEDITA TERRABUIO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
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- Risk factors and outcomes associated with recurrent autoimmune hepatitis following liver transplantation(2022) MONTANO-LOZA, Aldo J.; RONCA, Vincenzo; EBADI, Maryam; HANSEN, Bettina E.; HIRSCHFIELD, Gideon; ELWIR, Saleh; ALSAED, Mohamad; MILKIEWICZ, Piotr; JANIK, Maciej K.; MARSCHALL, Hanns-Ulrich; BURZA, Maria Antonella; EFE, Cumali; CALISKAN, Ali Riza; HARPUTLUOGLU, Murat; KABACAM, Gokhan; TERRABUIO, Debora; ONOFRIO, Fernanda de Quadros; SELZNER, Nazia; BONDER, Alan; PARES, Albert; LLOVET, Laura; AKYILDIZ, Murat; ARIKAN, Cigdem; MANNS, Michael P.; TAUBERT, Richard; WEBER, Anna-Lena; SCHIANO, Thomas D.; HAYDEL, Brandy; CZUBKOWSKI, Piotr; SOCHA, Piotr; OLDAK, Natalia; AKAMATSU, Nobuhisa; TANAKA, Atsushi; LEVY, Cynthia; MARTIN, Eric F.; GOEL, Aparna; SEDKI, Mai; JANKOWSKA, Irena; IKEGAMI, Toru; RODRIGUEZ, Maria; STERNECK, Martina; WEILER-NORMANN, Christina; SCHRAMM, Christoph; DONATO, Maria Francesca; LOHSE, Ansgar; ANDRADE, Raul J.; PATWARDHAN, Vilas R.; HOEK, Bart van; BIEWENGA, Maaike; KREMER, Andreas E.; UEDA, Yoshihide; DENEAU, Mark; PEDERSEN, Mark; MAYO, Marlyn J.; FLOREANI, Annarosa; BURRA, Patrizia; SECCHI, Maria Francesca; BERETTA-PICCOLI, Benedetta Terziroli; SCIVERES, Marco; MAGGIORE, Giuseppe; JAFRI, Syed-Mohammed; DEBRAY, Dominique; GIRARD, Muriel; LACAILLE, Florence; LYTVYAK, Ellina; MASON, Andrew L.; HENEGHAN, Michael; OO, Ye HtunBackground & Aims: Autoimmune hepatitis can recur after liver transplantation (LT), though the impact of recurrence on patient and graft survival has not been well characterized. We evaluated a large, international, multicenter cohort to identify the probability and risk factors associated with recurrent AIH and the association between recurrent disease and patient and graft survival. Methods: We included 736 patients (77% female, mean age 42 +/- 1 years) with AIH who underwent LT from January 1987 through June 2020, among 33 centers in North America, South America, Europe and Asia. Clinical data before and after LT, biochemical data within the first 12 months after LT, and immunosuppression after LT were analyzed to identify patients at higher risk of AIH recurrence based on histological diagnosis. Results: AIH recurred in 20% of patients after 5 years and 31% after 10 years. Age at LT <= 42 years (hazard ratio [HR] 3.15; 95% CI 1.22-8.16; p = 0.02), use of mycophenolate mofetil post-LT (HR 3.06; 95% CI 1.39-6.73; p = 0.005), donor and recipient sex mismatch (HR 2.57; 95% CI 1.39-4.76; p = 0.003) and high IgG pre-LT (HR 1.04; 95% CI 1.01-1.06; p = 0.004) were associated with higher risk of AIH recurrence after adjusting for other confounders. In multivariate Cox regression, recurrent AIH (as a time-dependent covariate) was significantly associated with graft loss (HR 10.79, 95% CI 5.37-21.66, p <0.001) and death (HR 2.53, 95% CI 1.48-4.33, p = 0.001). Conclusion: Recurrence of AIH following transplant is frequent and is associated with younger age at LT, use of mycophenolate mofetil post-LT, sex mismatch and high IgG pre-LT. We demonstrate an association between disease recurrence and impaired graft and overall survival in patients with AIH, highlighting the importance of ongoing efforts to better characterize, prevent and treat recurrent AIH. Lay summary: Recurrent autoimmune hepatitis following liver transplant is frequent and is associated with some recipient features and the type of immunosuppressive medications use. Recurrent autoimmune hepatitis negatively affects outcomes after liver transplantation. Thus, improved measures are required to prevent and treat this condition.
conferenceObject FACTORS ASSOCIATED WITH RECURRENCE OF AUTOIMMUNE HEPATITIS AFTER LIVER TRANSPLANTATION AND EFFECTS ON GRAFT AND PATIENT SURVIVAL(2019) MONTANO-LOZA, Aldo J.; EBADI, Maryam; HANSEN, Bettina E.; HIRSCHFIELD, Gideon; MASON, Andrew L.; MILKIEWICZ, Piotr; JANIK, Maciej; MARSCHALL, Hanns-Ulrich; BURZA, Maria Antonella; PARES, Albert; LLOVET, Laura Patricia; TERRABUIO, Debora; AKYILDIZ, Murat; ARIKAN, Cigdem; LIBERAL, Rodrigo; KERKAR, Nanda; BOER, Ynte S.; LOHSE, Ansgar W.; DRENTH, Joost P. H.; FLOREANI, Annarosa; CZUBKOWSKI, Piotr; SOCHA, Piotr; OLDAK, Natalia; BELLIDO, Raul Jesus Andrade; BURRA, Patrizia; SECCHI, Maria Francesca; LYTVYAK, Ellina; JANKOWSKA, Irena; RODRIGUEZ, Maria; STERNECK, Martina; WEILER-NORMANN, Christina; SCHRAMM, Christoph; TERZIROLI, Benedetta; SCHIANO, Thomas D.; HAYDEL, Brandy; DEBRAY, Dominique; GIRAND, Muriel; LACAILLE, Florence; DONATO, Maria Francesca; AKAMATSU, Nobuhisa; TANAKA, Atsushi; IKEGAMI, Toru; UEDA, Yoshihide; VERGANI, Diego; HENEGHAN, Michael A.conferenceObject A multicentric study to estimate mortality and graft loss risk after liver transplantation (LT) in patients with recurrent primary biliary cholangitis (PBC)(2022) MONTANO-LOZA, Aldo J.; BERNEY, Thierry; TOSO, Christian; MAGINI, Giulia; HIRSCHFIELD, Gideon; HANSEN, Bettina; MASON, Andrew L.; EBADI, Maryam; NEVENS, Frederik; ENDE, Natalie Van den; TERRABUIO, Debora Raquel; PARES, Albert; RUIZ, Pablo; BONDER, Alan; LYTVYAK, Ellina; MEER, Adriaan Van der; VEER, Rozanne de; FLOREANI, Annarosa; CAZZAGON, Nora; CASU, Stefania; RUSSO, Francesco Paolo; PEDERSEN, Mark; MAYO, Marlyn J.; MANNS, Michael P.; TAUBERT, Richard; KIRCHNER, Theresa; SCHIANO, Thomas; HAYDEL, Brandy; VERHELST, Xavier; ROBLES-DIAZ, Mercedes; JIMENEZ-PEREZ, Miguel; DUMORTIER, Jerome; LOHSE, Ansgar; SCHRAMM, Christoph; RUETHER, Darius; BERETTA-PICCOLI, Benedetta Terziroli; DONATO, Maria Francesca; CORPECHOT, ChristopheconferenceObject Multicentre international evaluation of autoimmune hepatitis and liver transplantation: disease recurrence is associated with recipient features, type of immunosuppression and impaired outcomes(2021) MONTANO-LOZA, Aldo J.; RONCA, Vincenzo; EBADI, Maryam; HANSEN, Bettina; HIRSCHFIELD, Gideon; ELWIR, Saleh; ALSAED, Mohamad; MILKIEWICZ, Piotr; JANIK, Maciej K.; MARSCHALL, Hanns-Ulrich; BURZA, Maria Antonella; EFE, Cumali; CALISKAN, Ali Riza; HARPUTLUOGLU, Murat; KABACAM, Gokhan; TERRABUIO, Debora Raquel; ONOFRIO, Fernanda; PARES, Albert; LLOVET, Laura Patricia; AKYILDIZ, Murat; ARIKAN, Cigdem; MANNS, Michael P.; TAUBERT, Richard; WEBER, Anna-Lena; SCHIANO, Thomas; HAYDE, Brandy; CZUBKOWSKI, Piotr; SOCHA, Piotr; OLDAK, Natalia; AKAMATSU, Nobuhisa; TANAKA, Atsushi; LEVY, Cynthia; MARTIN, Eric F.; GOEL, Aparna; SEDKI, Mai; JANKOWSKA, Irena; IKEGAMI, Toru; RODRIGUEZ, Maria; STERNECK, Martina; WEILER-NORMANN, Christina; SCHRAMM, Christoph; DONATO, Maria Francesca; LOHSE, Ansgar W.; ANDRADE, Raul J.; BONDER, Alan; PATWARDHAN, Vilas; HOEK, Bart Van; BIEWENGA, Maaike; KREMER, Andreas E.; UEDA, Yoshihide; DENEAU, Mark; PEDERSEN, Mark; MAYO, Marlyn J.; FLOREANI, Annarosa; BURRA, Patrizia; SECCHI, Maria Francesca; BERETTA-PICCOLI, Benedetta Terziroli; SCIVERES, Marco; MAGGIORE, Giuseppe; JAFRI, Syed-Mohammed; DEBRAY, Dominique; GIRARD, Muriel; LACAILLE, Florence; LYTVYAK, Ellina; MASON, Andrew L.; HENEGHAN, Michael; OO, Ye Htun