VIOLETA REGNIER GALVAO

(Fonte: Lattes)
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Lattes
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LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Current Allergy and Asthma Reports ×

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  • article 51 Citação(ões) na Scopus
    Perioperative Anaphylaxis
    (2014) GALVAO, Violeta Regnier; GIAVINA-BIANCHI, Pedro; CASTELLS, Mariana
    Perioperative anaphylaxis is a life-threatening condition with an estimated prevalence of 1: 3,500 to 1: 20,000 procedures and a mortality rate of up to 9 %. Clinical presentation involves signs such as skin rash, urticaria, angioedema, bronchospasm, tachycardia, bradycardia, and hypotension. Prompt recognition and treatment is of utmost importance to the patient's prognosis, since clinical deterioration can develop rapidly. Epinephrine is the main treatment drug, and its use should not be postponed, since delayed administration is associated with increased mortality. Elevated levels of serum tryptase help to confirm the diagnosis. The main agents involved in IgE-mediated perioperative anaphylaxis are neuromuscular blocking agents, latex, antibiotics, hypnotics, opioids, and colloids. Specific investigation should be conducted 4 to 6 weeks after the reaction and relies on skin tests, serum-specific IgE, and challenge procedures. This review aims to discuss the main aspects of perioperative anaphylaxis: risk factors, diagnosis, treatment, culprit agents, specific investigation, and preventive measures.
  • article 13 Citação(ões) na Scopus
    BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?
    (2019) CAMPOS, Lucila; GALVAO, Violeta Regnier; KALIL, Jorge; CASTELLS, Mariana; GIAVINA-BIANCHI, Pedro
    Purpose of ReviewThe aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives.Recent FindingsBasophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions.SummaryCurrently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests.