NEUSA YURIKO SAKAI VALENTE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
- Virchowian leprosy madarosis: histological evidence of a permanent non-cicatricial alopecia(2022) BRITO, F. F.; DONATI, A.; KAKIZAKI, P.; VALENTE, N. Y. S.; MICHALANY, N.; MACHADO, C. J.; HIRATA, S. H.
- Cutaneous metastasis of follicular thyroid carcinoma mimicking pyogenic granuloma [Metástase cutânea de carcinoma folicular de tireóide mimetizando granuloma piogênico](2018) RIBEIRO, C. P.; SILVA, F. O. da; DINIZ, T. A. C. B.; PIRES, M. C.; VALENTE, N. Y. S.O carcinoma folicular de tireóide é um tumor bem diferenciado, considerado o segundo subtipo mais comum de câncer de tireóide. Sua metástase geralmente ocorre por via hematogênica, principalmente para pulmões e ossos, porém é rara quando cutânea. Relatamos caso de paciente com carcinoma folicular de tireóide há 5 anos que percebeu lesão nodular exofítica de 1cm, eritematosa, friável no couro cabeludo com 7 meses de evolução, simulando granuloma piogênico. A biópsia revelou adenocarcinoma com diferenciação glandular e material coloide no lúmen. O perfil imuno-histoquímico foi positivo para CK-7 e tireoglobulina, favorecendo o diagnóstico de metástase cutânea de neoplasia primária da tireóide. © 2018 Sociedade Brasileira de Dermatologia.Follicular thyroid carcinoma is a well-differentiated tumor, and is considered the second most common subtype of thyroid cancer. Its metastasis usually arises hematogenously - mainly to the lungs and bones - and is considered rare when it occurs cutaneously. The authors report a case of a patient with follicular thyroid carcinoma for 5 years who noticed an erythematous, friable exophytic nodular lesion measuring 1cm on the scalp with 7 months of development, simulating a pyogenic granuloma. Biopsy analysis revealed an adenocarcinoma with glandular differentiation and colloid material in the lumen. The immunohistochemical profile was positive for CK-7 and thyroglobulin, favoring the diagnosis of cutaneous metastasis of primary thyroid neoplasia. © 2018 Sociedade Brasileira de Dermatologia.
- Areata-Like Lupus as a Clinical Manifestation of Cutaneous Lupus Erythematosus(2022) MORAIS, K. L.; SECCHIN, P.; ANZAI, A.; VERUSSA, M. J. M. C.; MUNCK, A.; FECHINE, C. O. C.; VALENTE, N. Y. S.; ROMITI, R.Introduction: Lupus erythematosus (LE) is a chronic autoimmune disease that frequently causes hair loss and scalp lesions. Hair loss can be scarring and nonscarring, diffuse, or patchy. The nonscarring patchy alopecia is usually related to systemic LE (SLE) and may simulate alopecia areata (AA), reason why it is named areata-like lupus. Our case was diagnosed with areata-like lupus but did not meet criteria for SLE. Case Report: A 63-year-old woman presented with irregular nonscarring patchy alopecia in the temporal and frontoparietal scalp. Trichoscopy showed exclamation mark hairs, vellus hairs, and sparse yellow dots. Histology revealed epidermal vacuolar interface dermatitis, lymphohistiocytic infiltrate around the bulbs of anagen follicles, and eccrine glands. Direct immunofluorescence showed deposits of C3, IgA, and IgG in the basement membrane zone. Discussion: Patients with cutaneous LE can also manifest as nonscarring patchy alopecia that is clinically similar to AA, despite the absence of systemic manifestations. Areata-like lupus is secondary to the lupus autoimmune infiltrate that affects the skin including the hair follicles. Trichoscopy, histology, and direct immunofluorescence are important to differentiate this form of alopecia from AA, which is believed to have a higher incidence in lupus patients.
- Poroid hidradenoma: A rare adnexa tumor(2018) ABUAWAD, Y. G.; SILVA, F. O. da; PORTOCARRERO, L. K. L.; DINIZ, T. A. C. B.; WESTIN, A. T.; VALENTE, N. Y. S.The poroid hidradenoma is a rare benign intradermal neoplasm rare that is poorly described in the literature. It usually affects elderly individuals and is characterized as a solitary, painless and well-circumscribed nodule. The diagnosis is confirmed by the histological characteristics of the hidradenomas and poromas. The treatment corresponds to complete surgical excision, thus avoiding recurrence and malignancy. The authors report a case of a 64 year-old patient, with a single, well-delimited and asymptomatic nodular lesion that had emerged 5 months before. © 2018 Sociedade Brasileira de Dermatologia.O hidradenoma poroide é uma neoplasia intradérmica benigna rara e pouco descrita na literatura. Afeta geralmente indivíduos idosos e caracteriza-se como nódulo solitário, indolor e bem circunscrito. O diagnóstico é firmado por características histológicas de hidradenomas e poromas. O tratamento é realizado através de excisão cirúrgica completa, evitando assim recidiva e malignização. Relatamos caso de uma paciente, 64 anos, com lesão nodular única, bem delimitada e assintomática há 5 meses. © 2018 Sociedade Brasileira de Dermatologia.
- Novel blue blotch lesions in folliculitis decalvans - a clinical, histopathological and immunohistochemical study of seven cases(2021) DOCHE, I.; REBEIS, M. M.; GERLERO, P.; VALENTE, N. Y. S.; RIVITTI-MACHADO, M. C.
article 1 Citação(ões) na Scopus Actinic Granuloma Annulare With Scarring and Open Comedones(2017) GAVIOLI, C. F. B.; VALENTE, N. Y. S.; SANGUEZA, M.; NICO, M. M.Actinic granuloma and annular elastolytic giant cell granuloma are variants of granuloma annulare affecting, respectively, sun-exposed and sun-covered skin sites on where, besides classical findings, abundant elastophagocytosis is observed. Here, we report a case of exuberant actinic granuloma annulare that, in addition to extensive scarring, showed multiple overlying open comedones. Markedly dilated follicular infundibula filled with compact masses of laminated keratinous material were observed in proximity to dermal inflammation composed of many histiocytes and multinucleated giant cells in close association with degenerated elastic fibers and abundant elastophagocytosis.- Porokeratoma: A new clinical entity? [Poroqueratoma: Uma nova entidade clínica?](2018) SILVA, F. O. da; DINIZ, T. A. C. B.; ABUAWAD, Y. G.; BARBOSA, M. A. H.; SARAIVA, M. I. R.; CUNHA, T. A. C.; VALENTE, N. Y. S.O poroqueratoma é entidade definida como acantoma com características de poroceratose. Apresenta padrão histopatológico distinto de lamela cornóide e diferenças clínicas em relação à poroceratose típica. Trata-se de uma afecção recentemente descrita, com poucos casos relatados na literatura. Apresentamos caso de paciente do sexo masculino, 46 anos, com lesão nodular exofítica, localizada na região interglútea. O exame histopatológico evidenciou múltiplas lamelas cornóides, sendo as periféricas as mais bem definidas. Devido à apresentação clínica e histopatológica, o diagnóstico foi de poroqueratoma. © 2018 Sociedade Brasileira de Dermatologia.Porokeratoma is an entity defined as an acanthoma with porokeratosis characteristics. It has a distinct histological pattern from that of the cornoid lamella and has clinical differences regarding the typical porokeratosis. The condition has been described only recently and there are few cases reported in the literature. The authors report the case of a 46 year-old male patient with an exophytic nodular lesion located in the intergluteal region. Histological examinations evidenced multiple cornoid lamellae, with those located on the periphery being better defined. Based on the clinical and histological appearance, the lesion was diagnosed as a porokeratoma. © 2018 Sociedade Brasileira de Dermatologia.
- Overexpression of the aryl hydrocarbon receptor in frontal fibrosing alopecia and lichen planopilaris: a potential pathogenic role for dioxins?: an investigational study of 38 patients(2020) DOCHE, I.; PAGLIARI, C.; HORDINSKY, M. K.; WILCOX, G. L.; RIVITTI-MACHADO, M. C. M.; ROMITI, R.; VALENTE, N. Y. S.; SHAIK, J. A.; SALDANHA, M.; SOTTO, M. N.
- Clinical and immunological profile of umbilical involvement in pemphigus vulgaris and pemphigus foliaceus(2013) OLIVEIRA JUNIOR, J. V.; MARUTA, C. W.; SOUSA JR., J. X.; SANTI, C. G.; VALENTE, N. Y. S.; ICHIMURA, L. M. F.; PERIGO, A. M.; AOKI, V.Background. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune vesicobullous disorders with IgG autoantibodies directed against desmoglein (Dsg)1 and 3, which lead to intraepidermal acantholysis. Aim. To characterize the clinical and immunological profile of patients with PF or PV with umbilical involvement. Methods. In total, 10 patients (7 women, 3 men; age range 2470 years, disease duration 316 years) diagnosed with either PV (n = 5) or mucocutaneous PF (n = 5) were assessed according to their clinical features, histopathology and immunological findings [direct and indirect immunofluorescence (DIF and IIF) and ELISA with recombinant Dsg1 and Dsg3]. Results. Erythema, erosions, crusts and vegetating skin lesions were the main clinical features of the umbilical region. DIF of the umbilical region gave positive results for intercellular epidermal IgG and C3 deposits in eight patients and for IgG alone in the other two. Indirect immunofluorescence with IgG conjugate showing the typical pemphigus pattern was positive in all 10 patients, with titres varying from 1 : 160 to 1 : 2560. ELISA with recombinant Dsg1 gave scores of 24266 in PF and 0270 in PV. Reactivity to recombinant Dsg3 was positive in all five patients with PV (ELISA 2298) and was negative in all PF sera. Conclusions. All 10 patients with pemphigus with umbilical presentation had the clinical and immunopathological features of either PF or PV. This peculiar presentation, not yet completely elucidated, has rarely been reported in the literature. A possible explanation for this unique presentation may be the presence of either novel epitopes or an association with embryonic or scar tissue located in the umbilical-cord region.
- Isolated eyebrow loss in frontal fibrosing alopecia: relevance of early diagnosis and treatment(2016) ANZAI, A.; DONATI, A.; VALENTE, N. Y. S.; ROMITI, R.; TOSTI, A.