NEUSA YURIKO SAKAI VALENTE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Clinicopathologic correlation of 282 leukocytoclastic vasculitis cases in a tertiary hospital(2016) HERINGER, Antonio Pedro Ribeiro; OLIVEIRA, Caroline Maris Takatu Neves de; AOKI, Valeira; VALENTE, Neusa Yuriko Sakai; SANCHEZ, Paula Cristina de Faria; CRIADO, Paulo RicardoconferenceObject Clinical features, etiologic findings, and therapeutic response in a series of 44 patients with recurrent erythema multiforme(2012) BARBOSA, Camila Anna; SANTI, Claudia Giuli; MARAGNO, Luciana; VALENTE, Neusa Sakay; GABBI, TatianaBackground: Erythema multiforme (EM) is a mucocutaneous disorder usually self-limited but potentially recurrent. Recurrent erythema multiforme (REM) etiology is not always evident and represents a therapeutic challenge. Aim: To report clinical, etiologic, and therapeutic aspects in 44 REM patients from São Paulo, Brazil. Methods: Datawereretrospectively collected from 44 REM cases from 2000 to 2011. Results: Out of 44 patients, 29 (66%) were female, mean age at disease onset was 35.2 and average of 4.6 outbreaks per year. Forty-three patients (98%) had cutaneous lesions. Mucous membranes involvement was present in 37 patients (84%), 37 patients with oral, 19 with genital and 4 with ocular involvement. Nineteen patients out of 44 (43%) referred herpetic lesions preceding EM outbreaks, 16 were submitted to Tzanck smear and six presented a positive result for herpes simplex cytophatic effect findings. Thirty-seven patients (84%) received prednisone, 39 (88%) prophylactic acyclovir, 8 (18%) valacyclovir, and 10 (23%) dapsone. Twenty-seven of 39 patients receiving continuous acyclovir treatment had partial or complete treatment response. Recalcitrant cases were submitted to alternative treatments: 3 out of 8 patients had partial response to valacyclovir and 5 out of 9 patients had either partial or complete response to dapsone. Three patients used either thalidomide or azathioprine without enough follow-up. Conclusion: REM maintains etiologic uncertainties that lead, at times, to suboptimal therapeutic responses. The relationship between HSV and REM cannot always be proved by laboratory examination, but prophylactic therapy with acyclovir should be considered.conferenceObject Ross syndrome: A case report(2017) COSENZA, Fernanda Dagir; VALENTE, Neusa; FERREIRA, Paula; MENTA, MarcelloconferenceObject Sweet syndrome: Retrospective study of 83 patients, emphasizing clinical and histopathologic features and associations(2016) COSTA, Jose Ricardo Casarin; VIRGENS, Anangelica Rodrigues; DIAS, Natasha Favoretto; SAMORANO, Luciana Paula; VALENTE, Neusa Yuriko Sakai; NETO, Cyro FestaconferenceObject Analysis of the Expression of Toll-like Receptors 2 and 4 in Keratinocytes of Patients with Extensive Dermatophytosis due Trichophyton rubrum(2012) CRIADO, P. R.; OLIVEIRA, C. B.; VASCONCELLOS, C.; VALENTE, N. Y. S.; SOTTO, M. N.; LUIZ, F. Guedes; BELDA JUNIOR, W.Rationale There are few studies to concern the role of innate immune response in dermatophytosis, so we conducted an investigation to define the involvement of TLRs in the course of tinea corporis by T. rubrum. Methods We allocated 14 patients without primary or secondary immunosuppression with extensive dermatophytosis, defined as the ringworm on at least 3 body segments of the same patient. In each patient the skin were biopsied from the active edge of the tinea and normal skin distant at least 4 cm of the lesion. Other skin fragments (control skin) were obtained from cosmetic surgery and without tinea. We use immunohistochemical staining with antibodies for antigens TLR 2 and 4. Images were analyzed in Image Pro Plus program. Results The Wilcoxon Signed Ranks Test showed: (i) regarding the expression of TLR2 of patients with tinea, found on the skin surface, average percentage of the marked area of 24.36 (1-76) in skin with tinea and 39.77 (9-84) in normal skin, p 0.043; (ii) analysis of TLR4 expression in the epidermis of patients with tinea met index higher optical density in normal skin than in skin with tinea, average 111.21 (99.44 to 134.34) and 104.50 (97.76 to 113.82), respectively, p 0.028. Conclusions We found a lower expression of TLR2 and 4 in the skin with tinea compared to healthy skin of the same patients with extensive dermatophytosis, as well as a tendency toward higher expression of TLR2 in the healthy peripheral skin, which could explain the spread in extension, in these cases of tinea.