ADRIANA CORACINI TONACIO DE PROENCA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject Yellow Fever Vaccination in Brazil: Short-Term Safety in Pediatric Autoimmune Rheumatic Diseases(2018) AIKAWA, Nadia E.; BALBI, Verena A.; TONACIO, Adriana C.; SALLUM, Adriana M. E.; CAMPOS, Lucia M. A.; KOZU, Katia T.; VENDRAMINI, Margarete B.; FONTOURA, Nicole; SARTORI, Ana M. C.; ANTONANGELO, Leila; SILVA, Clovis A.; BONFA, EloisabookPart Cuidados Pré-Imunossupressão(2018) LOPES, Michelle Remião Ugolini; PROENçA, Adriana Coracini Tonácio de; SOUZA, Fernando Henrique Carlos de; MORAES, Júlio César Bertacini de- MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection(2018) PAQUIN-PROULX, Dominic; AVELINO-SILVA, Vivian I.; SANTOS, Bianca A. N.; BARSOTTI, Nathalia Silveira; SIROMA, Fabiana; RAMOS, Jessica Fernandes; TONACIO, Adriana Coracini; SONG, Alice; MAESTRI, Alvino; CERQUEIRA, Natalia Barros; FELIX, Alvina Clara; LEVI, Jose Eduardo; GREENSPUN, Benjamin C.; ROUGVIE, Miguel de Mulder; ROSENBERG, Michael G.; NIXON, Douglas F.; KALLAS, Esper G.Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are pre-dominantly transmitted via mosquito bites. Both viruses are responsible for a growing number of infections in tropical and subtropical regions. DENV infection can cause lethargy with severe morbidity and dengue shock syndrome leading to death in some cases. ZIKV is now linked with Guillain-Barre A syndrome and fetal malformations including microcephaly and developmental disorders (congenital Zika syndrome). The protective and pathogenic roles played by the immune response in these infections is unknown. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells with potent anti-bacterial activity. MAIT cells have also been postulated to play a role in the immune response to viral infections. In this study, we evaluated MAIT cell frequency, phenotype, and function in samples from subjects with acute and convalescent DENV infection. We found that in acute DENV infection, MAIT cells had elevated co-expression of the activation markers CD38 and HLA-DR and had a poor IFN gamma response following bacterial stimulation. Furthermore, we found that MAIT cells can produce IFN gamma in response to in vitro infection with ZIKV. This MAIT cell response was independent of MR1, but dependent on IL-12 and IL-18. Our results suggest that MAIT cells may play an important role in the immune response to Flavivirus infections.
bookPart Infecção em Pacientes Reumatológicos Imunossuprimidos(2018) PROENçA, Adriana Coracini Tonácio deconferenceObject PULMONARY FIBROSIS AT THE TIME OF DERMATOMYOSITIS/POLIMYOSITIS DIAGNOSIS: A PREDICTIVE FACTOR FOR PULMONARY AND EXTRA-PULMONARY TUBERCULOSIS(2018) SILVA, Taysa C. M. Da; PROENCA, Adriana C. T.; SHINJO, Samuel K.conferenceObject Short-Term Safety of Fractional-Dose Yellow Fever Vaccination in Autoimmune Rheumatic Diseases and Kinetics of White Blood Cells(2018) TONACIO, Adriana C.; PEDROSA, Tatiana N.; FERREIRA FILHO, Julio C. R.; SAMPAIO-BARROS, Marilia M.; FULLER, Ricardo; LOPES, Michelle; BORBA, Eduardo Ferreira; PASOTO, Sandra G.; NEVES, Emilly; SILVA, Clovis A.; PEREIRA, Rosa M. R.; SAMPAIO-BARROS, Percival; ANDRADE, Danieli; RIBEIRO, Ana C. M.; MORAES, Julio C. B.; SHINJO, Samuel K.; MIOSSI, Renata; HIGASHINO, Hermes; COSTA, Silvia; DUARTE, Alberto; LEON, Elaine P.; LOPES, Marta; AIKAWA, Nadia E.; BONFA, Eloisa