DENISE FREDIANI BARBEIRO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
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Resultados de Busca
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conferenceObject Obesity protects heart but increases lung injury by endotoxin inflammation(2014) LIMA, T. M. D.; MALDONADO, M. C.; PETRONI, R.; BARBEIRO, D.; SORIANO, F. G.; SILVA, F. Pinheiro daconferenceObject Obesity alters sepsis induced pulmonary inflammation(2012) LIMA-SALGADO, T.; FUNGARO, T. P.; PETRONI, R. C.; OLIVEIRA, S. J. S.; BARBEIRO, D. F.; SORIANO, F. G.Purpose/Objective: Sepsis is a severe disease that represents a significant healthcare burden worldwide, while obesity has reached epidemic proportions over the last few decades. Although the mechanism is uncharted, it is known that obesity increases morbidity and mortality in sepsis through its multiple effects on many organ systems, including pulmonary function. Our aim was to investigate the effects of obesity in systemic and pulmonary inflammatory process in an experimental model of endotoxemic shock. Materials and methods: Animals were fed a high fat diet (30% of fat) for 6 weeks and then injected with 15 mg/kg LPS i.p. They were euthanatized after 6, 24 and 48 h. Inflammation was characterized by measurement of plasma and pulmonary cytokines. The mRN expression of cytokines and tissue remodeling proteins was determined by real time PCR. Results: Obesity decreased the survival rate of the animals 24 h after LPS injection. There was higher plasma concentration of IL1-beta, IL-6and TNF-alpha in these animals. Furthermore, there was higher concentration of IL-6 in the obese mice’s lungs after 6 h of endotoxemia. However, the mRNA expression of pro-inflammatory factors (IL-6, TNF-alpha, IL-1beta and MMP9) was lower, suggesting they may be converted to proteins. Obese mice presented higher mRNA expression of TGF-beta after 6 h, indicating a reparative process. Conclusions: Obesity may be an additional complication factor in sepsis induced pulmonary inflammation.conferenceObject Cardiovascular risk and coronary artery calcium score after liver transplantation: study at fouth year(2017) LINHARES, L. M.; OLIVEIRA, C. P.; ALVARES-DA-SILVA, M. R.; STEFANO, J. T.; GEBRIM, E. M.; BARBEIRO, H. V.; BARBEIRO, D. F.; TERRABUIO, D. R.; ABDALA, E.; SORIANO, F. G.; CARRILHO, F. J.; FARIAS, A. Q.; AUGUSTO, L.; ALBUQUERQUE, C. D'conferenceObject PERITONEAL LAVAGE IN ACUTE PANCREATITIS: DOES THE SEVERITY OF THE DISEASE INFLUENCE THE OUTCOME?(2020) SERRA, Mariana B.; BARBEIRO, Denise F.; LIMA, Thais; BARROSO, Wermerson; SORIANO, Francisco G.; MACHADO, Marcel C. C.; SOUZA, Heraldo P.conferenceObject CONVENTIONAL AND NOVEL CARDIOVASCULAR RISK FACTORS IN LIVER TRANSPLANT RECIPIENTS (LTR)(2012) ALVARES-DA-SILVA, M. R.; OLIVEIRA, C.; STEFANO, J. T.; OKAMATSU, E.; BARBEIRO, H.; BARBEIRO, D. F.; SORIANO, F.; FARIAS, A. Q.; CARRILHO, F. J.; D'ALBUQUERQUE, L. A. C.