FELIX JOSE ALVAREZ RAMIRES
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
16 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 16
conferenceObject Impact of sympathectomy upon myocardium(2019) PESSOA, F. Fernanda; JORDAO, M. R.; FONSECA, K. C. B.; ZANONI, F.; SALEMI, V. M. C.; RIBEIRO, O. N.; SOUZA, L. E.; FERNANDES, F.; IRIGOYEN, M. C.; MOREIRA, L. F. P.; MADY, C.; RAMIRES, F. J. A.conferenceObject Effect of the angiotensin receptor neprilysin inhibitor LCZ696 compared with enalapril according to systolic blood pressure in PARADIGM-HF(2015) BOHM, M.; REFSGAARD, J.; RAMIRES, F. J. A.; ROULEAU, J. L.; SOLOMON, S. D.; SWEDBERG, K.; ZILE, M.; SHI, V. C.; PACKER, M.; MCMURRAY, J. J. V.conferenceObject Brain natriuretic peptide predicts mortality in patients undergoing pericardiectomy for constrictive pericarditis(2014) MELO, D. T. P.; FERNANDES, F.; GUALANDRO, D. M.; SALEMI, V. M. C.; OLIVETTI, N. Q. S.; BUCK, P. C.; DIAS, R. R.; RAMIRES, F. J. A.; CARAMELLI, B.; MADY, C.conferenceObject Chagas cardiomyopathy : prognostic value of genetic polymorphisms of TNF -alpha(2014) ALVES, S. M.; VIEIRA, J. Lannes; ARNEZ, L. E. A.; MORAES, M. O.; OLIVEIRA JR., W. A.; SARTESCHI, C.; MELO, M. G. A.; RAMIRES, F. J. A.; MADY, C.conferenceObject The role of air pollution upon chagas cardiomyopathy(2017) FONSECA, K. C. B.; PESSOA, F. Fernanda; MADY, C.; HOTTA, V.; RIBEIRO, O. N.; FERNANDES, F.; NASCIMENTO, R. S.; SALDIVA, P. H. N.; RAMIRES, F. J. A.conferenceObject Galectin-3 levels are normal in patients with constrictive pericarditis and are associated with exercise intolerance after pericardiectomy(2018) FERNANDES, F.; MELLO, D. T. P.; RAMIRES, F. J. A.; SABINO, E. C.; MOREIRA, C. H. V.; BENVENUTTI, L.; HOTTA, V. T.; SAYEG, A.; DIAS, R. R.; MADY, C.conferenceObject Impairment of parasympathetic and sympathetic nervous systems in different forms of Chagas disease(2013) FERNANDES, F.; BARBOSA-FERREIRA, J. M.; RAMIRES, F. J. A.; GRUPI, C. J.; HACHUL, D. T.; IANNI, B. M.; DABARIAN, A.; NASTARI, L.; BUCK, P. C.; MADY, C.conferenceObject Non-invasive assessment of myocardial stiffness by the two-dimensional shear wave elastography ultrasound technique in patients with amyloidosis and Fabry disease(2023) CAFEZEIRO, C.; NETO, A. C. Alencar; BUENO, B. V. K.; RISSATO, J. H.; PEREIRA, N. M.; PEREIRA, F. L.; RAMIRES, F. J. A.; MATHIAS JR., W.; ROCHITTE, C. E.; HOTTA, V. T.; DABARIAN, A. L.; FERNANDES, F.- The role of air pollution in myocardial remodeling(2017) OLIVEIRA-FONOFF, A. M. de; MADY, C.; PESSOA, F. G.; FONSECA, K. C. B.; SALEMI, V. M. C.; FERNANDES, F.; SALDIVA, P. H. N.; RAMIRES, F. J. A.Background Excessive air pollution in urban environments can impact morbidity and mortality. The authors evaluated the role of particulate matter(2.5) (PM2.5) in structural, geometric, and functional remodeling in hearts, using an experimental model of myocardial infarction. Methods and findings Seventy-five rats were divided into 5 groups: control (CG), CG exposed to PM2.5 pollution (CGP), myocardial infarcted group (MI), infarcted group immediately exposed to pollution (IGP-I), and infarcted group previously exposed to pollution and kept exposed after infarction (IGP-II). Greater deposition of interstitial collagen occurred in the left ventricle in CGP, MI, IGP-I, and IGP-II groups compared with that in controls (p = 0.002 CG vs CGP and p<0.0001 CG vs MI, IGP-I, and IGP-II). In the right ventricle, greater collagen deposition existed in CGP, MI, IGP-I, and IGP-II compared with that in CG (p<0.021 CG vs CGP and p<0.0001 CG vs MI, IGP-I, and IGP-II). At the end of the study, CG had a higher mean shortening fraction than the other groups had (p <= 0.03). Left ventricular systolic diameter was lower in CG than in infarcted groups (p <= 0.003). The infarcted groups had greater expression of TGF-beta (p <= 0.04). PM2.5 increased the expression of TGF-beta in the IGP-II compared with the MI group (p = 0.004). The TNF-alpha gene was overexpressed in the IGP-II compared with the CGP group (p = 0.012). INF-gamma gene expression was greater in IGP-II (p <= 0.01). Oxidative stress analysis showed a higher glutathione concentration in CGP (p = 0.03), MI (p = 0.014), and IGP-I (p = 0.008) compared with that in CG. Conclusions PM2.5 stimulates the deposition of fibrosis in the myocardium of healthy hearts, but not in infarcted hearts. PM2.5 modulates the inflammatory response, which was greater in the IGP-II group. It also modulates oxidative stress in healthy hearts but not in infarcted hearts.
conferenceObject Air pollution on myocardial remodeling in acute phase of Chagas disease in experimental model.(2019) FONSECA, Keila; PESSOA, F. G.; MADY, C.; HOTTA, V. T.; RIBEIRO, O. N.; FERNANDES, F.; IANNI, B. M.; SALDIVA, P. H. N.; RAMIRES, F. J. A.