PAULO HENRIQUE BRAZ DA SILVA

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LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina

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search.filters.applied.f.dateIssued: 2017 × Indexador: MEDLINE ×

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Agora exibindo 1 - 4 de 4
  • article 5 Citação(ões) na Scopus
    Oral lesions as an important marker for HIV progression
    (2017) BRAZ-SILVA, P. H.; SCHUSSEL, J. L.; ORTEGA, K. L.; GALLOTTINI, M.
    Background: Oral hairy leukoplakia (OHL) is a benign lesion caused by Epstein-Barr virus (EBV) replication in the oral epithelium affecting the borders of the tongue. It is strongly associated with immunosuppression, especially in HIV+ adults but is uncommon in pediatric population. The aim of the study is to show the importance of the correct diagnosis of OHL and its influence on HIV treatment. We report two cases of HIV+ adolescent patients that presented with leukoplakic lesions on the border of the tongue, suggestive of OHL. OHL diagnosis was confirmed in only one case through EBV in situ hybridization. After confirmation of the diagnosis, the patient with OHL was referred to an infectious disease specialist with the decision to start antiretroviral therapy. Conclusion: OHL definitive diagnosis can help clinical management of pediatric HIV+ patients. © 2017 by the article author(s).
  • article 9 Citação(ões) na Scopus
    Detection of human polyomaviruses JC and BK in liver pretransplant patients
    (2017) FIGUEIREDO, M. A.; FINK, M. C. Domingues; CASTRO, T.; BRAZ-SILVA, P. H.; STEFFENS, J. C.; EDUARDO, F. P.; GALLOTTINI, M.; ORTEGA, K. L.
    ObjectiveThis study aimed to identify and quantify polyomaviruses (BKPyV and JCPyV) in the saliva, mouthwash, blood and urine of liver pretransplant patients. Materials and MethodsA case-control study was performed using a convenience sample of 21 end-stage liver disease patients (EG=experimental group) and 20 normoreactive controls (CG=control group). In total, 162 samples were collected. Detection and quantification of polyomaviruses were performed using real-time PCR method. ResultsIn the EG, 21 samples (25%) were positive for BKPyV and 10 (11.90%) for JCPyV, while in the CG, 27 samples (34.61%) were positive for BKPyV and six (7.69%) for JCPyV. With regard to the number of samples positive for BKPyV and JCPyV, there was no statistically significant difference between EG and CG (p=.52 and p=.25). In the EG, we observed a panorama similar to that of the CG regarding the presence of polyomaviruses in mouthwash, blood and urine. The greatest difference between the samples was that regarding the identification of BKPyV in saliva. ConclusionCirrhotic patients on the liver transplant waiting list did not show higher prevalence of BKPyV and JCPyV compared to normoreactive controls.
  • conferenceObject
    The Presence of CMV and HSV-1 Reactivation in Saliva May Play a Role in the Oral Mucositis Severity
    (2017) ALVES, Bruna; TORREGROSSA, Vinicius R.; BRAZ-SILVA, Paulo H.; MIRANDA, Eliana C. M.; PALMIERI, Michelli; TOZETTO-MENDOZA, Tania R.; CORREA, Maria Elvira P.
  • article 8 Citação(ões) na Scopus
    Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy treatment for head and neck squamous cell carcinoma
    (2017) PALMIERI, Michelle; MARTINS, Victor Adriano de Oliveira; SUMITA, Laura Masami; TOZETTO-MENDOZA, Tania Regina; ROMANO, Bruna Baraldi; MACHADO, Clarisse Martins; PANNUTI, Claudio Sergio; BRANDAO, Thais Bianca; RIBEIRO, Ana Carolina Prado; CORREA, Luciana; BRAZ-SILVA, Paulo Henrique
    Opportunistic infections may affect the oral mucosa of patients undergoing radio/chemotherapy through exacerbation of oral mucositis. The aim of this study is to evaluate the oral shedding of all eight human herpesviruses and its possible association with oral mucositis. In this prospective cohort study, we analyzed oral rinse samples, collected weekly, from 20 patients during radiotherapy treatment. Serologic status to HSV1 and HSV2, EBV, CMV, and VZV in three different periods was performed by ELISA assay. PCR and enzymatic digestion was performed to detect HSV1, HSV2, EBV, CMV, VZV, HHV6, HHV7, and HHV8. Oral mucositis was evaluated according to the WHO criteria. Oral shedding of EBV, HHV6, and HHV7 was observed in all weeks of radiotherapy. Considering the episodes of shedding, the highest frequency was found in patients with EBV excretion (55.0%). No virus reactivation was observed by serological analysis. EBV oral shedding frequency was significantly higher than that of other viruses and showing a positive correlation with oral mucositis grade >= 2. There was a positive correlation between EBV oral shedding and oral mucositis grade >= 2, particularly after 3 weeks of radiotherapy, a period in which the severity of mucositis was statistically higher. These findings allow us to infer that the local inflammatory environment in mucositis grade >= 2 is more favorable for EBV replication. Mucositis is a frequent and important side effect of radio/chemotherapy treatment. Understanding the possible participation of viruses in the mechanism of this condition is important to develop strategies for treatment and prevention.