KARLA MATHIAS DE ALMEIDA
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
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bookPart Tratamento do transtorno bipolar e transtornbos relacionados(2021) ALMEIDA, Karla Mathias; MAIA, Eduardo Barretto; TONIOLO, Ricardo Alexandre; GOMES, Bernardo Carramão; LAFER, Beny- Personality traits in bipolar disorder type I: a sib-pair analysis(2011) ALMEIDA, Karla Mathias; NERY, Fabiano G.; MORENO, Ricardo Alberto; GORENSTEIN, Clarice; LAFER, BenyObjective: The aim of this study was to compare temperament and character traits among patients with bipolar disorder (BD), their siblings, and healthy controls (HCs) in order to examine whether personality traits are related to the genetic vulnerability to develop BD. Methods: Using the Temperament and Character Inventory, we assessed 204 subjects: 67 euthymic outpatients with bipolar disorder type I, 67 siblings without BD, and 70 HCs. Results: Scores on harm avoidance, novelty seeking, and selftranscendence were significantly higher among patients with BD than among HCs, whereas those on self-directedness and cooperativeness were significantly lower. Siblings showed higher scores on harm avoidance and lower scores on self-directedness than did HCs. As some of the siblings presented at least one lifetime psychiatric disorder other than BD (n = 35), we examined the subset of siblings who had no lifetime psychiatric disorder (n = 32). This group showed statistically higher harm avoidance scores than HCs. Conclusions: Our results suggest that the harm avoidance temperament trait and, to a lesser extent, the self-directedness character trait may represent vulnerability factors for BD.
- Neither bipolar nor obsessive-compulsive disorder: compulsive buyers are impulsive acquirers(2012) FILOMENSKY, Tatiana Zambrano; ALMEIDA, Karla Mathias; NOGUEIRA, Marcelo Campos Castro; DINIZ, Juliana Belo; LAFER, Beny; BORCATO, Sonia; TAVARES, HermanIntroduction: Compulsive buying (CB) is currently classified as an impulse control disorder (ICD) not otherwise classified. Compulsive buying prevalence is estimated at around 5% of the general population. There is controversy about whether CB should be classified as an ICD, a subsyndromal bipolar disorder (BD), or an obsessive-compulsive disorder (OCD) akin to a hoarding syndrome. To further investigate the appropriate classification of CB, we compared patients with CB, BD, and OCD for impulsivity, affective instability, hoarding, and other OCD symptoms. Method: Eighty outpatients (24 CB, 21 BD, and 35 OCD) who were neither manic nor hypomanic were asked to fill out self-report questionnaires. Results: Compulsive buying patients scored significantly higher on all impulsivity measures and on acquisition but not on the hoarding subdimensions of clutter and ""difficulty discarding."" Patients with BD scored higher on the mania dimension from the Structured Clinical Interview for Mood Spectrum scale. Patients with OCD scored higher on obsessive-compulsive symptoms and, particularly, higher on the contamination/washing and checking dimensions from the Padua Inventory; however, they did not score higher on any hoarding dimension. A discriminant model built with these variables correctly classified patients with CB (79%), BD (71%), and OCD (77%). Conclusion: Patients with CB came out as impulsive acquirers, resembling ICD- rather than BD- or OCD-related disorders. Manic symptoms were distinctive of patients with BD. Hoarding symptoms other than acquisition were not particularly associated with any diagnostic group.
bookPart Transtorno bipolar(2021) LAFER, Beny; NASCIMENTO, Camila; NUNES, Paula Villela; ALMEIDA, Karla MathiasbookPart Por que uma seção de medicina do estilo de vida em um tratamento de psiquiatria?(2021) ALMEIDA, Karla Mathias; CARVALHO, Ana Paula Lopes