FERNANDA RODRIGUES LIMA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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article 14 Citação(ões) na Scopus Effects of acute aerobic exercise on leukocyte inflammatory gene expression in systemic lupus erythematosus(2016) PERANDINI, L. A.; SALES-DE-OLIVEIRA, D.; ALMEIDA, D. C.; AZEVEDO, H.; MOREIRA-FILHO, C. A.; CENEDEZE, M. A.; BENATTI, F. B.; LIMA, F. R.; BORBA, E.; BONFA, E.; SA-PINTO, A. L.; ROSCHEL, H.; CAMARA, N. O.; GUALANO, B.Systemic lupus erythematosus (SLE) is an autoimmune disease with a persistent systemic inflammation. Exercise-induced inflammatory response in SLE remains to be fully elucidated. The aim of this study was to assess the effects of acute exercise on leukocyte gene expression in active (SLEACTIVE) and inactive SLE (SLEINACTIVE) patients and healthy controls (HC). Methods: All subjects (n = 4 per group) performed a 30-min single bout of acute aerobic exercise (similar to 70% of VO2 peak) on a treadmill, and blood samples were collected for RNA extraction from circulating leukocyte at baseline, at the end of exercise, and after three hours of recovery. The expression of a panel of immune-related genes was evaluated by a quantitative PCR array assay. Moreover, network-based analyses were performed to interpret transcriptional changes occurring after the exercise challenge. Results: In all groups, a single bout of acute exercise led to the down-regulation of the gene expression of innate and adaptive immunity at the end of exercise (e.g., TLR3, IFNG, GATA3, FOXP3, STAT4) with a subsequent up-regulation occurring upon recovery. Exercise regulated the expression of inflammatory genes in the blood leukocytes of the SLE patients and HC, although the SLE groups exhibited fewer modulated genes and less densely connected networks (number of nodes: 29, 40 and 58; number of edges: 29, 60 and 195; network density: 0.07, 0.08 and 0.12, for SLEACTIVE, SLEINACTIVE and HC, respectively). Conclusion: The leukocytes from the SLE patients, irrespective of disease activity, showed a down-regulated inflammatory gene expression immediately after acute aerobic exercise, followed by an up-regulation at recovery. Furthermore, less organized gene networks were observed in the SLE patients, suggesting that they may be deficient in triggering a normal exercise-induced immune transcriptional response.- Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases(2012) PERANDINI, Luiz Augusto; SA-PINTO, Ana Lucia de; ROSCHEL, Hamilton; BENATTI, Fabiana Braga; LIMA, Fernanda Rodrigues; BONFA, Eloisa; GUALANO, BrunoChronic inflammation is a common feature shared by several autoimmune rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, idiopathic inflammatory myopathies, systemic sclerosis, and ankylosing spondylitis. Therefore, blocking or reducing inflammation is one of the major treatment strategies in these diseases. In this context, exercise training has emerged as a potential therapeutic tool in counteracting systemic inflammation, thereby leading to better clinical outcomes. The aims of this review are i) to provide a summary of the clinical effects of exercise training in selected autoimmune rheumatic diseases; and ii) to discuss the potential anti-inflammatory role of exercise training in autoimmune rheumatic diseases, stressing the gaps in literature and the clinical and scientific perspectives in the field.
- Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?(2017) PINTO, Ana Jessica; ROSCHEL, Hamilton; PINTO, Ana Lucia de Sa; LIMA, Fernanda Rodrigues; PEREIRA, Rosa Maria Rodrigues; SILVA, Clovis Artur; BONFA, Eloisa; GUALANO, BrunoThis review aims to (1) summarize the estimates of physical inactivity and sedentary behavior in autoimmune rheumatic diseases; (2) describe the relationship between physical (in) activity levels and disease-related outcomes; (3) contextualize the estimates and impact of physical inactivity and sedentary behavior in autoimmune diseases compared to other rheumatic diseases and chronic conditions; and (4) discuss scientific perspectives around this theme and potential clinical interventions to attenuate these preventable risk factors. We compiled evidence to showthat estimates of physical inactivity and sedentary behavior in autoimmune rheumatic diseases are generally comparable to other rheumatic diseases as well as to other chronic conditions (e.g., type 2 diabetes, cardiovascular diseases, and obesity), in which a lack of physical activity and excess of sedentary behavior are well-known predictors of morbimortality. In addition, we also showed evidence that both physical inactivity and sedentary behavior may be associated with poor health-related outcomes (e.g., worse disease symptoms and low functionality) in autoimmune rheumatic diseases. Thus, putting into practice interventions to make the patients ""sit less and move more"", particularly light-intensity activities and/or breaking-up sedentary time, is a simple and prudent therapeutic approach to minimize physical inactivity and sedentary behavior, which are overlooked yet modifiable risk factors in the field of autoimmune rheumatic diseases.
article 26 Citação(ões) na Scopus Inflammatory cytokine kinetics to single bouts of acute moderate and intense aerobic exercise in women with active and inactive systemic lupus erythematosus(2015) PERANDINI, L. A.; SALES-DE-OLIVEIRA, D.; V, S. B. Mello; CAMARA, N. O.; BENATTI, F. B.; LIMA, F. R.; BORBA, E.; BONFA, E.; ROSCHEL, H.; SA-PINTO, A. L.; GUALANO, B.Objectives: The aim of this study was to evaluate changes in the cytokines INF-gamma, IL-10, IL-6, TNF-alpha and soluble TNF receptors (sTNFR1 and sTNFR2) in response to single bouts of acute moderate and intense exercise in systemic lupus erythematosus women with active (SLEACTIVE) and inactive (SLEINACTIVE) disease. Methods: Twelve SLEINACTIVE women (age: 35.3 +/- 5.7 yrs: 25.6 +/- 3.4 kg/m(2)), eleven SLEINACTIVE women (age: 30.4 +/- 4.5 yrs; 26.1 +/- 4.8 kg/m(2)), and 10 age- and BMI-matched healthy control women (HC) performed 30 minutes of acute moderate (similar to 50% of VO(2)peak) and intense (similar to 70% of VO(2)peak) exercise bout. Cytokines and,soluble TNF receptors were assessed at baseline, immediately after; every 30 minutes up to three howls, and 24 hours after both acute exercise bouts. Results: In response to acute moderate exercise, cytokines and soluble TNF receptors levels remained unchanged in all groups (P>0.05), except for a reduction in IL-6 levels in the SLEACTIVE group at the 60th and 180th minutes of recovery (P<0.05), and a reduction in sTNFR1 levels in the He group at the 90th, 120th, 150th, 180th minutes of recovery (P<0.05). The SLEINACTIVE group showed higher levels of TNF-alpha, sTNFR1, and sTNFR2 at all time points when compared with the HC group (P<0.05). Also, the SLEACTIVE group showed higher levels of IL-6 at the 60th minute of recovery (P<0.05) when compared with the HC group. After intense exercise, sTNFR1 levels were reduced at the 150th (P=0.041) and 180th (P=0.034) minutes of recovery in the group. whereas the other cytokines and sTNFR2 levels remained unchanged (P>0.05). hi the He group, IL-10, TNF-alpha, sTNFR1, and sTNFR2 levels did not change, whilst INF-gamma levels decreased (P=0.05) and IL-6 levels increased immediately after the exercise (P=0.028), returning to baseline levels 24 hours later (P > 0.05). When compared with the HC group, the SLEINACTIVE, group showed higher levels of TNF-alpha and sTNFR2 in all time points, and higher levels of sTNFR1 at the end of exercise and at the 30th minute of recovery (P<0.05). The SLEACTIVE group also showed higher levels of TNF-alpha at all time points when compared with the HC group (P<0.05), (except after 90 min, 120 min and 24 hours of recovery) (P>0.05). Importantly, the levels of all cytokine and soluble TNF receptors returned to baseline 24 hours after the end of acute exercise, irrespective of its intensity in all three groups (P>0.05). Conclusion: This study demonstrated that both the single bouts of acute moderate and intense exercise induced mild and transient changes in cytokine levels in both SLEINACTIVE and SLEACTIVE women, providing novel evidence that acute aerobic execise does not trigger inflammation in patients with this disease.- Physical exercise among patients with systemic autoimmune myopathies(2018) OLIVEIRA, Diego Sales de; MISSE, Rafael Giovani; LIMA, Fernanda Rodrigues; SHINJO, Samuel KatsuyukiSystemic autoimmune myopathies (SAMs) are a heterogeneous group of rare systemic autoimmune diseases that primarily affect skeletal muscles. Patients with SAMs show progressive skeletal muscle weakness and consequent functional disabilities, low health quality, and sedentary lifestyles. In this context, exercise training emerges as a non-pharmacological therapy to improve muscle strength and function as well as the clinical aspects of these diseases. Because many have feared that physical exercise exacerbates inflammation and consequently worsens the clinical manifestations of SAMs, it is necessary to evaluate the possible benefits and safety of exercise training among these patients. The present study systematically reviews the evidence associated with physical training among patients with SAMs.