LUCIANA PARENTE COSTA SEGURO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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conferenceObject Induction of Lupus Nephritisin in Real Situation: Cyclophosphamide or Mycophenolate Mofetil?(2017) MUNHOZ, Gabriela; LACERDA, Maira; LOPES, Michelle; BORBA, Eduardo Ferreira; SEGURO, Luciana; BONFA, EloisaconferenceObject Early and Late Onset Biopsy Proven Lupus Nephritis without Other Associated Autoimmune Diseases: Severity and Long-Term Outcome(2017) LOPES, Michelle; SANTOS, Laryssa; SEGURO, Luciana; BONFA, EloisaconferenceObject Early Proteinuria Response in Real Life Situation Predicts Long-Term Lupus Renal Outcome in Ethnically Diverse Group with Biopsy-Proven Nephritis(2016) LOPES, Michelle; SEGURO, Luciana; CASTRO, Maite; DAFFRE, Danielle; BORBA, Eduardo Ferreira; BONFA, EloisaconferenceObject Effectiveness of Renoprotective Approaches in Lupus Nephritis: More Than Just Immunosuppression(2015) CASTRO, Maite; BORBA, Eduardo Ferreira; LOPES, Michelle; PASOTO, Sandra G.; BONFA, Eloisa; SEGURO, Luciana- Impact of Distinct Therapies on Antibody Response to SARS-CoV-2 Vaccine in Systemic Lupus Erythematosus(2022) YUKI, Emily F. N.; BORBA, Eduardo F.; PASOTO, Sandra G.; SEGURO, Luciana P.; LOPES, Michelle; SAAD, Carla G. S.; MEDEIROS-RIBEIRO, Ana Cristina; SILVA, Clovis A.; ANDRADE, Danieli C. O. de; KUPA, Leonard de Vinci K.; BETANCOURT, Lorena; BERTOGLIO, Isabela; VALIM, Juliana; HOFF, Camilla; FORMIGA, Francisco F. C.; PEDROSA, Tatiana; KALLAS, Esper G.; AIKAWA, Nadia E.; BONFA, EloisaObjective To date, the only study that has assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 mRNA) vaccine in systemic lupus erythematosus (SLE) observed a moderate response, but the sample size precluded an accurate analysis of the effect of individual drugs. Therefore, we evaluated the immunogenicity of an inactivated SARS-CoV-2 vaccine (Sinovac-CoronaVac) and the influence of different medications in SLE. Safety was also assessed. Methods We conducted a prospective controlled study of 232 SARS-CoV-2-naive SLE patients and 58 SARS-CoV-2-naive controls who were vaccinated with 2 doses of Sinovac-CoronaVac with a 28-day interval (day 0/day 28 [D0/D28]). Immunogenicity analysis at D0/D28 and D69 included anti-SARS-CoV-2 S1/S2 IgG seroconversion (SC) and neutralizing antibodies (NAb) positivity. The influence of individual drugs on immune response and safety was assessed. Results Patients and controls were well balanced for age (P = 0.771). At D69, SLE patients showed a moderate SC (70.2% versus 98.1%; P < 0.001) and moderate frequency of NAb positivity (61.5% versus 84.6%; P = 0.002), although both frequencies were lower than in controls. Factors associated with lower SC in univariate analysis at D69 were prednisone use (odds ratio [OR] 0.215 [95% confidence interval (95% CI) 0.108-0.427], P < 0.001) and mycophenolate mofetil (MMF) use (OR 0.201 [95% CI 0.107-0.378], P < 0.001), whereas hydroxychloroquine (HCQ) use led to a 2.5 increase in SC (P = 0.011). SLE patients who were receiving HCQ monotherapy had similar SC to controls at D69 (100% versus 98.1%; P = 1.000). In multivariate analysis, prednisone and MMF use were independently associated with lower SC (P < 0.001) and NAb positivity (P < 0.001). Safety analysis revealed no moderate/severe adverse events. Conclusion Sinovac-CoronaVac has a moderate immunogenicity in SARS-CoV-2-naive SLE patients with an excellent safety profile. We further demonstrate that HCQ may improve SC, whereas prednisone and MMF had a major deleterious effect in vaccine response, reinforcing the need to investigate the role of temporary MMF withdrawal or a vaccine-booster dose ( identifier: NCT04754698).
conferenceObject Early DAS28 Drop Is a Predictor for Clinical Response to Anti-TNF Agents in Patients with Rheumatoid Arthritis: An Observational Study of a Real Life Inception Cohort(2016) RIBEIRO, Ana C. M.; BONFIGLIOLI, Karin.; MIOSSI, Renata; SAAD, Carla G. S.; MORAES, Julio C. B.; WAISBERG, Mariana G.; SOUZA, Fernando Henrique Carlos de; AIKAWA, Nadia E.; PRADO, Leandro L. do; LOPES, Michelle; SEGURO, Luciana; BONFA, Eloisa