LUCIANA PARENTE COSTA SEGURO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject CLINICAL AND SEROLOGICAL COMPARATIVE ANALYSIS OF SYSTEMIC SCLEROSIS WITH OR WITHOUT OVERLAP SYNDROMES IN A LARGE BRAZILIAN COHORT(2014) SILVA, C. M.; PASOTO, S. G.; VIANA, V. S.; SEGURO, L. P. C.; ANDRADE, D. C. O.; BONFA, E.; SAMPAIO-BARROS, P. D.article 4 Citação(ões) na Scopus Hypomagnesaemia and hypocalcaemia in a patient with systemic sclerosis: role of proton pump inhibitors(2014) PEREZ, M. O.; NEVES, E. F. V.; BORTOLAI, C. B. C.; SAMPAIO-BARROS, P. D.; ANDRADE, D. C. O.; SEGURO, L. P. C.Proton pump inhibitors (PPI) are widely used in patients with systemic sclerosis (SSc) due to the chronic gastroesophageal reflux. The authors report a female patient with a 9-year history of SSc and long-term use of omeprazole, who complained of paresthesia and asthenia for 12 months. Physical examination revealed clinical signs of hypocalcaemia confirmed by laboratory tests that also showed hypomagnesaemia. After exclusion of possible causes, hypomagnesaemia secondary to PPI was diagnosed and omeprazole was replaced by a histamine H2-receptor antagonist: ranitidine. Despite continuous magnesium supplementation, the reintroduction of PPI at a lower dose due to worsening of dyspeptic symptoms led to recurrence of hypomagnesaemia. After definitive suspension of PPI, reintroduction of ranitidine and optimisation of anti-reflux environmental measures, the patient stabilised. In conclusion, SSc patients using PPIs should have their magnesium and calcium serum levels measured periodically, and non-specific symptoms such as asthenia, generalised paresthesia or life-threatening manifestations (seizures, arrhythmias) should not be neglected.article 0 Citação(ões) na Scopus Kidney biopsy is mandatory in cases of silent arterial hypertension in scleroderma renal crisis: a case report(2014) KOBAYASHI, C. B. C.; BENTO, R. H.; MALHEIROS, D. M. A. C.; ANDRADE, D.; SEGURO, L. C. P.; SAMPAIO-BARROS, P. D.conferenceObject ENVIRONMENTAL FACTORS AND INDUCTION OF SYSTEMIC SCLEROSIS: ANALYSIS OF 211 CONSECUTIVE PATIENTS(2014) SAMPAIO-BARROS, P.; AQUILA, L.; MEDEIROS, A. C.; SEGURO, L.; ANDRADE, D.conferenceObject INFLUENCE OF GENDER, ETHNICITY AND AGE AT ONSET IN THE CLINICAL PRESENTATION OF SYSTEMIC SCLEROSIS IN A LARGE BRAZILIAN COHORT OF 1017 PATIENTS(2014) SAMPAIO-BARROS, P.; MARANGONI, R.; ROCHA, L.; BORTOLUZZO, A.; SEGURO, L.; RIO, A. P. Del; ANDRADE, D.; NASCIMENTO, I.; FOELKEL, A. L.; MARQUES-NETO, J. F.article 1 Citação(ões) na Scopus Coronary aneurysms in a child: an unusual presentation of pseudovasculitis(2013) SEGURO, L. P. C.; CARVALHO, J. Freire de; LIANZA, A.; PEREIRA, R. M. R.Abnormalities of the coronary arteries in children are rare and Kawasaki disease is the most common cause of acquired coronary disease in a paediatric population. We report a case of a female child with coronary artery aneurysms and convulsions, who was diagnosed with Kawasaki disease. Due to systemic arterial hypertension and persistence of high inflammatory markers after treatment with high dose glucocorticoid and intravenous immunoglobulin, further investigation was performed and revealed a pheochromocytoma. Surgical removal led to normalisation of blood pressure and laboratory parameters. Periodic echocardiography studies revealed progressive reduction of coronary aneurysms, with complete normalisation after 8 months. This is the first case described of coronary aneurysms presenting as a pseudovasculitis syndrome associated with pheochromocytonza.