JOSE SOARES JUNIOR

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Lattes
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 11
  • article 16 Citação(ões) na Scopus
    Assessment of late anthracycline-induced cardiotoxicity by I-123-mIBG cardiac scintigraphy in patients treated during childhood and adolescence
    (2017) SANTOS, Marcelo Jose dos; ROCHA, Euclides Timoteo da; VERBERNE, Hein J.; SILVA, Eduardo Tinois da; ARAGON, Davi Casale; SOARES JUNIOR, Jose
    Purpose. The goal of this study was to evaluate late cardiotoxic effects of anthracyclines (ATC) by evaluating cardiac sympathetic activity in a cohort of asymptomatic patients previously treated with ATC for childhood cancers. Methods. We studied 89 asymptomatic patients previously treated with ATC with a normal echocardiogram (49 men and 40 women) and a control group of 40 healthy individuals (26 men and 14 women). Both groups underwent planar myocardial I-123-meta-iodobenzylguanidine scintigraphy (I-123-mIBG). From these images, the early and late heart-to-mediastinum (H/M) ratio and washout rate (WR) were assessed. Results. The mean survival at the time of the I-123-mIBG scintigraphy was 5.3 +/- 3.4 years. Patients treated with ATC had a lower but clinical normal left ventricular ejection fraction (LVEF) compared to controls (60.44 +/- 6.5 vs 64.1 +/- 6.0%, P < 0.01). Both the late H/M ratio and WR were not able to discriminate ATC treated patients from controls. The cumulative ATC dose was the only independent predictor of the LVEF, explaining approximately 12% of the variation in LVEF (P = 0.01). Conclusions. Although the pathophysiology behind ATC cardiotoxicity is most likely multifactorial, myocardial sympathetic activity is not associated with a reduction in LVEF 5-years after completion of chemotherapy.
  • bookPart
  • bookPart
    Inflamação e infecção cardiovasculares
    (2017) MENEGHETTI, José Cláudio; JúNIOR, José Soares; IZAKI, Marisa; GIORGI, Maria Clementina P.
  • article 1 Citação(ões) na Scopus
    Case Report: Multivessel Coronary Disease Assessment with SPECT Tc-99m-Sestamibi and Rubidium-82 PET/CT
    (2017) PADILHA, Bruno Gomes; SABINO, Daniela; GIORGI, Maria Clementina; SOARES JR., Jose; IZAKI, Marisa; MENEGHETTI, Jose Claudio
  • bookPart
    Cintilografia cardíaca com pirofosfato
    (2017) MENEGHETTI, José Cláudio; JúNIOR, José Soares; IZAKI, Marisa; GIORGI, Maria Clementina P.
  • bookPart
    Avaliação da função ventricular
    (2017) MENEGHETTI, José Cláudio; JúNIOR, José Soares; IZAKI, Marisa; GIORGI, Maria Clementina P.
  • bookPart
    Medicina nuclear: O que ela acrescenta?
    (2017) JúNIOR, José Soares
  • article 4 Citação(ões) na Scopus
    Left ventricular function in response to dipyridamole stress: head-to-head comparison between (82)Rubidium PET and Tc-99m-sestamibi SPECT ECG-gated myocardial perfusion imaging
    (2017) GIORGI, Maria Clementina; MENEGHETTI, Jose Claudio; SOARES JR., Jose; IZAKI, Marisa; FALCAO, Andrea; IMADA, Rodrigo; CHALELA, William; OLIVEIRA, Marco Antonio de; NOMURA, Cesar; VERBERNE, Hein J.
    Myocardial perfusion imaging (MPI) with Tc-99m-sestamibi (sestamibi) SPECT and rubidium-82 (Rb-82) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. A group of 221 consecutive patients (65.2 +/- 10.4 years, 52.9% male) underwent consecutive sestamibi and Rb-82 MPI after a single dipyridamole stress dose. Sestamibi and Rb-82 summed rest (SRS), stress (SSS) and difference (SDS) scores, and LV end-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were compared. Bland-Altman analysis showed that with increasing ESV and EDV the difference between the two perfusion tracers increased both at rest and post-stress. The mean difference in EDV and ESV between the two perfusion tracers at rest could both be independently explained by the Rb-82 SDS and the sestamibi SRS. The combined models explained approximately 30% of the variation in these volumes between the two perfusion tracers (R-2 = 0.261, p = 0.005; R-2 = 0.296, p < 0.001, for EDV and ESV respectively). However, the mean difference in LVEF between sestamibi and Rb-82 showed no significant trend post-stress (R-2 = 0.001, p = 0.70) and only a modest linear increase with increasing LVEF values at rest (R-2 = 0.032, p = 0.009). Differences in left ventricular volumes between sestamibi and Rb-82 MPI increase with increasing volumes. However, these differences did only marginally affect LVEF between sestamibi and Rb-82. In clinical practice these results should be taken into account when comparing functional derived parameters between sestamibi and Rb-82 MPI.
  • bookPart
    Viabilidade miocárdica
    (2017) MENEGHETTI, José Cláudio; JúNIOR, José Soares; IZAKI, Marisa; GIORGI, Maria Clementina P.
  • bookPart
    Cintilografia de perfusão miocárdica
    (2017) MENEGHETTI, José Cláudio; JúNIOR, José Soares; IZAKI, Marisa; GIORGI, Maria Clementina P.; PADILHA, Bruno Gomes